-
公开(公告)号：US5504008A
公开(公告)日：1996-04-02
申请号：US274606
申请日：1994-07-13
CPC分类号： C12N9/1029 , C12N9/12
摘要： There is disclosed a method for providing for the coexpression of N-myristoyltransferase and a protein substrate for said N-myristoyltransferase in E. coli comprising introducing into E. coli a dual plasmid system comprising (A) the isopropyl-.beta.-D-thiogalactopyranoside-inducible tac promoter, the g10-L ribosome binding site, a NMT gene, the kanamycin resistance gene and the p15A origin of replication in operable sequence and (B) the recA promoter, the g10-L ribosome binding site, a mammalian gene, the ampicillin resistance gene and the Col E1 origin of replication in operable sequence. This allows production of mammalian N-myristoylproteins or proteins containing covalently linked analogs of myristate with altered physical-chemical properties.
-
公开(公告)号：US20110177976A1
公开(公告)日：2011-07-21
申请号：US13002137
申请日：2009-06-30
申请人： Jeffrey I. Gordon , Peter Turnbaugh
发明人： Jeffrey I. Gordon , Peter Turnbaugh
CPC分类号： G01N33/56911 , A23V2002/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , A23V2200/332
摘要： Methods of modulating body fat or weight loss are presented Nucleic acid and protein microarrays that comprise biomolecules associated with an obese host microbiome or a lean host microbiome are utilized for analysis.
摘要翻译： 提供调节体脂肪或体重减轻的方法使用包含与肥胖宿主微生物组织或贫血宿主微生物组合物相关的生物分子的核酸和蛋白质微阵列进行分析。
-
13.发明授权Tetradecadienoic acid, a glycosyl phosphatidylinositol (GPI) analogue used for inhibiting parasitic activity 失效十四碳二烯酸，用于抑制寄生活性的糖基磷脂酰肌醇（GPI）类似物
公开(公告)号：US5760259A
公开(公告)日：1998-06-02
申请号：US617246
申请日：1996-03-18
IPC分类号： A61K31/20 , A61K31/201 , A61K31/22 , A61K31/23 , C07C57/03 , C07C57/30 , C07C57/42 , C07C59/64 , C07C59/66 , C07C59/68 , C07C255/34 , C07C255/37 , C07D333/24 , C07K57/03
CPC分类号： C07D333/24 , A61K31/20 , A61K31/201 , A61K31/22 , A61K31/23 , C07C255/34 , C07C255/37 , C07C57/03 , C07C57/30 , C07C57/42 , C07C59/64 , C07C59/66 , C07C59/68
摘要： A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycotyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.
摘要翻译： 公开了一种抑制寄生活性的方法，其中所述寄生虫的糖基磷脂酰肌醇（GPI）锚的生物合成，结构和/或功能可能受到掺入所述GPI锚定物中选择的含有各种杂原子，取代基和不饱和的杂原子的肉豆蔻酸类似物的影响 键，包括含酯类似物，含有酮羰基的类似物，含硫类似物，含双键和三键的类似物，含芳香族部分的类似物，硝化类似物和卤代类似物。
-
14.发明授权Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid 失效使用肉豆蔻酸的二杂原子取代的类似物N-酰化肽和蛋白质的方法
公开(公告)号：US5571689A
公开(公告)日：1996-11-05
申请号：US218399
申请日：1994-03-28
IPC分类号： A61K31/20 , A61K31/23 , C07C59/125 , C07C59/60 , C07C323/12 , C07C323/52 , C07K1/00 , C07K1/107 , C12N9/10 , C12P21/06 , C07K1/13 , C12P7/00 , C12P11/00
CPC分类号： C12N9/1029 , A61K31/20 , A61K31/23 , C07C323/12 , C07C323/52 , C07C59/125 , C07C59/60 , C07K1/006 , C07K1/1077
摘要： A method for acylating peptides and proteins with the CoA-ester of diheteroatom substituted C.sub.13 to C.sub.14 myristic acid analogs catalyzed by N-myristoyltransferase is presented. In the analogs, two non-adjacent methylene groups, which are normally at positions 3-13, are replaced with oxygen or sulfur atoms.
摘要翻译： 提出了用N-肉豆蔻酰转移酶催化的双杂交原子取代C13至C14肉豆蔻酸类似物的CoA酯酰化肽和蛋白质的方法。 在类似物中，通常在3-13位的两个不相邻的亚甲基被氧或硫原子取代。
-
公开(公告)号：US5151445A
公开(公告)日：1992-09-29
申请号：US638709
申请日：1991-01-08
IPC分类号： A01N37/36 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/22 , A61K31/23 , A61P33/00 , A61P33/02 , C07C59/125 , C07C59/60 , C07C323/52 , C07K1/00
CPC分类号： C07C59/125 , A61K31/19 , A61K31/20 , A61K31/22 , A61K31/23 , C07C323/52 , C07C59/60 , C07K1/006
摘要： A method of inhibiting parasitic activity is disclosed in which the biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor of said parasite is inhibited by incorporating into said GPI anchor an oxy-substituted fatty acid analog in place of myristate. The inhibitory compounds ar C.sub.13 and C.sub.14 fatty acids or alkyl esters thereof in which a methylene group normally in carbon position 4 to 13 of said fatty acid is replaced with oxygen.
摘要翻译： 公开了抑制寄生活性的方法，其中所述寄生虫的糖基磷脂酰肌醇（GPI）锚的生物合成通过在所述GPI锚中加入取代的脂肪酸类似物代替肉豆蔻酸酯而被抑制。 其中通常在所述脂肪酸的第4至13位的亚甲基被氧代替的抑制性化合物ar C13和C14脂肪酸或其烷基酯。
-
公开(公告)号：US6025511A
公开(公告)日：2000-02-15
申请号：US52210
申请日：1998-03-31
IPC分类号： A61K31/20 , A61K31/201 , A61K31/22 , A61K31/23 , C07C57/03 , C07C57/30 , C07C57/42 , C07C59/64 , C07C59/66 , C07C59/68 , C07C255/34 , C07C255/37 , C07D333/24 , C07C53/00
CPC分类号： C07D333/24 , A61K31/20 , A61K31/201 , A61K31/22 , A61K31/23 , C07C255/34 , C07C255/37 , C07C57/03 , C07C57/30 , C07C57/42 , C07C59/64 , C07C59/66 , C07C59/68
摘要： A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.
摘要翻译： 公开了一种抑制寄生活性的方法，其中所述寄生虫的糖基磷脂酰肌醇（GPI）锚的生物合成，结构和/或功能可能受到掺入所述GPI锚定物中选择的含有各种杂原子，取代基和不饱和的杂原子的类似物的影响 键，包括含酯类似物，含有酮羰基的类似物，含硫类似物，含双键和三键的类似物，含芳香族部分的类似物，硝化类似物和卤代类似物。
-
公开(公告)号：US5625124A
公开(公告)日：1997-04-29
申请号：US273411
申请日：1994-07-11
申请人： Per Falk , Jeffrey I. Gordon
发明人： Per Falk , Jeffrey I. Gordon
IPC分类号： C12N9/10 , C12N15/85 , C12N5/00 , A61K49/00 , G01N33/567
CPC分类号： C12N15/8509 , A01K67/0278 , C12N9/1051 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , C12N2830/008
摘要： Transgenic non-human animals are described which serve as a model for H. pylori infection of epithelial cells of the stomach and small intestine. The gut epithelial cells of the transgenic animals express one or more surface carbohydrate antigens which act as receptors for the bacterium H. pylori, a known causative agent of acid peptic disease, such as gastritis, stomach ulcers, duodenal ulcers, and strongly correlated with the development of gastric neoplasia. Methods for making and using the transgenic animals are also disclosed. The transgenic animals can be used to screen for compounds and conditions which block binding of H. pylori to the gut epithelium and/or ameliorate the H. pylori-associated pathogenesis of acid peptic disease and gastric adenocarcinoma.
摘要翻译： 描述了作为幽门螺杆菌感染胃和小肠上皮细胞的模型的转基因非人动物。 转基因动物的肠上皮细胞表达一种或多种表面碳水化合物抗原，其作为细菌幽门螺杆菌的受体，幽门螺杆菌是酸消化性疾病的已知致病因子，例如胃炎，胃溃疡，十二指肠溃疡，并且与 发展胃肿瘤。 还公开了制备和使用转基因动物的方法。 转基因动物可用于筛选阻断幽门螺杆菌与肠上皮结合和/或改善幽门螺杆菌相关的酸性消化性疾病和胃腺癌发病机理的化合物和病症。
-
公开(公告)号：US5397701A
公开(公告)日：1995-03-14
申请号：US198717
申请日：1994-02-18
IPC分类号： A61K31/41 , A61K31/655 , A61P31/12 , C07C247/12 , C07C323/52 , C07D249/02 , C07D249/04 , C07D257/04 , C07D521/00 , C07K1/107 , C07K1/113 , C07K14/00 , C12N9/10 , C12P21/02 , C12P21/00
CPC分类号： C07D257/04 , C07C247/12 , C07C323/52 , C07D231/12 , C07D233/56 , C07D249/04 , C07D249/08 , C07K1/1077 , C12N9/1029
摘要： Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure:Z--(CH.sub.2).sub.x COORwhereinZ=azido, tetrazolyl or triazolylR=H or C.sub.1 -C.sub.8 alkyl, andx=8-12.
摘要翻译： 公开了可用于肽和蛋白质和抗病毒剂的脂肪酸酰化的叠氮取代的脂肪酸类似物，其具有以下化学结构：Z-（CH 2）x COOR其中Z =叠氮基，四唑基或三唑基R = H或C1- C8烷基，x = 8-12。
-
公开(公告)号：US4778878A
公开(公告)日：1988-10-18
申请号：US102975
申请日：1987-09-30
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
摘要翻译： 公开了具有如下氨基酸序列或其生理上可接受的酰胺或盐衍生物的肉豆蔻酰化酶的八肽抑制剂：
-
20.发明申请GUT MICROBIOME AS A BIOMARKER AND THERAPEUTIC TARGET FOR TREATING OBESITY OR AN OBESITY RELATED DISORDER 审中-公开作为生物标记的杀菌微生物和用于治疗肥胖或肥胖相关疾病的治疗目标公开(公告)号：US20100172874A1
公开(公告)日：2010-07-08
申请号：US12519958
申请日：2007-12-10
CPC分类号： A61K35/741 , A61K35/74 , C12Q1/04 , G01N2570/00
摘要： The present invention relates to the gut microbiome as a biomarker and therapeutic target for energy harvesting, weight loss or gain, and/or obesity in a subject. In particular, the invention provides methods of altering and monitoring the relative abundance of Bacteroides and Firmicutes in the gut microbiome of a subject.
摘要翻译： 本发明涉及作为生物标志物的肠微生物组合物和受试者的能量收获，体重减轻或增益和/或肥胖的治疗靶标。 特别地，本发明提供了改变和监测受试者肠道微生物组织中拟杆菌和坚果的相对丰度的方法。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.024 秒)
