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148 条记录 (耗时 0.029 秒)

    Process for the enantioselective epoxidation of C═C double bonds
    13.
    发明授权
    Process for the enantioselective epoxidation of C═C double bonds 失效
    C = C双键的对映选择性环氧化方法

    公开(公告)号：US06225482B1

    公开(公告)日：2001-05-01

    申请号：US09451100

    申请日：1999-11-30

    申请人： Karlheinz Drauz ,  Stan M. Roberts ,  John Skidmore

    发明人： Karlheinz Drauz ,  Stan M. Roberts ,  John Skidmore

    IPC分类号： C07D30332

    CPC分类号： C07D303/32

    摘要： A process for the enantioselective epoxidation of C═C double bonds and use of the epoxides. The present invention provides a process for the enantioselective epoxidation of compounds of the formula I by means of a diastereomer and enantiomer enriched homopolyamino acid and an oxidizing agent. The epoxides prepared according to the invention are used as intermediates in organic syntheses.

    摘要翻译： C = C双键的对映选择性环氧化方法和环氧化物的使用方法。本发明提供了通过非对映异构体和对映异构体富集的均聚氨基酸和氧化剂对式I化合物进行对映选择性环氧化的方法。 根据本发明制备的环氧化物用作有机合成中的中间体。

    Use of aqueous L-Tryptophan and/or L-Threonine salt solutions
    14.
    发明授权
    Use of aqueous L-Tryptophan and/or L-Threonine salt solutions 失效
    使用L-色氨酸水溶液和/或L-苏氨酸盐溶液

    公开(公告)号：US06162442A

    公开(公告)日：2000-12-19

    申请号：US741112

    申请日：1996-10-30

    申请人： Hermann Lotter ,  Karlheinz Drauz

    发明人： Hermann Lotter ,  Karlheinz Drauz

    IPC分类号： A23K1/00 ,  A23K1/16 ,  C07C211/00 ,  C07D401/00 ,  C07D403/10 ,  A61K9/44

    CPC分类号： A23K20/142 ,  A23K40/00

    摘要： Highly concentrated aqueous L-Tryptophan and/or L-Threonine salt solutions are used to supplement mixed feeds with L-Tryptophan and/or L-Threonine. They can be metered easily and accurately, can be produced in a highly concentrated form with a content of between 30 and 70% and are storage stable to a surprisingly high degree (slight tendency to crystallize, no chemical decomposition, no racemization) even over a relatively long period of at least three months when outside temperatures are low.

    摘要翻译： 高浓度的L-色氨酸水溶液和/或L-苏氨酸盐溶液用于补充与L-色氨酸和/或L-苏氨酸的混合饲料。 它们可以容易且精确地计量，可以高度浓缩的形式生产，含量在30-70％之间，并且即使在一个或多个的情况下也能保持稳定，达到惊人的高度（轻微的结晶趋势，没有化学分解，没有外消旋化） 室外温度较低时，至少三个月相对较长。

    Process for obtaining active L-.alpha.-amino carboxylic acids from corresponding racemic d, L-.alpha.-amino carboxylic acids
    16.
    发明授权
    Process for obtaining active L-.alpha.-amino carboxylic acids from corresponding racemic d, L-.alpha.-amino carboxylic acids 失效
    从相应的外消旋d，L-α-氨基羧酸获得活性的L-α-氨基羧酸的方法

    公开(公告)号：US6114163A

    公开(公告)日：2000-09-05

    申请号：US94321

    申请日：1998-06-16

    申请人： Karlheinz Drauz ,  Andreas Bommarius ,  Michael Karrenbauer ,  Gunter Knaup

    发明人： Karlheinz Drauz ,  Andreas Bommarius ,  Michael Karrenbauer ,  Gunter Knaup

    IPC分类号： C07C227/34 ,  C07C227/36 ,  C07C319/20 ,  C07C323/60 ,  C12P13/04 ,  C12P41/00 ,  C07C1/00

    CPC分类号： C12P41/007 ,  C07C227/34 ,  C07C227/36 ,  C07C319/20 ,  C12P13/04

    摘要： The disclosure relates to a process for obtaining optically active L-.alpha.-aminocarboxylic acids from the corresponding racemic D,L,.alpha.-aminocarboxylic acids. The following steps are involved: (a) the D,L,.alpha.-aminocarboxylic acids are acetylated; (b) the N-acetyl-L-.alpha.-aminocarboxylic acid present in the mixture of N-acetyl-D,L,.alpha.-aminocarboxylic acids thus obtained is broken down enzymatically into the L-.alpha.-aminocarboxylic acid; (c) the L-.alpha.-aminocarboxylic acid is separated from the mixture, a quantity of a solution of N-acetyl-D(L)-.alpha.-aminocarboxylic acids and a quantity of acetate equivalent to the L-.alpha.-aminocarboxylic acid being retained; and (d) the N-acetyl-D(L)-.alpha.-aminocarboxylic acid is racemized and recycled for enzymatic breakdown. Known extraction processes involving steps (a) to (d) have the disadvantage of producing large quantities of salt. Specifically, the processes are far removed from the ideal equation, according to which one hundred percent of the acetic anhydride and the D,L,.alpha.-aminocarboxylic acids are converted to L-.alpha.-aminocarboxylic acids and acetic acid. Adjusting the retained solution from step (c) in such a way as to obtain a solution consisting essentially of N-acetyl-D-(L)-.alpha.-aminocarboxylic acid salt and free acetic acid in equilibrium with acetate and free N-acetyl-D(L)-.alpha.-aminocarboxylic acid and from which acetic acid is extracted by distillation makes it surprisingly easy to feed the solution formed as "mother liquor" following separation of the L-.alpha.-aminocarboxylic acid in the circuit and to achieve a materials balance as close as possible to the ideal.

    摘要翻译： 本公开涉及从相应的外消旋D，L，α-氨基羧酸获得光学活性的L-氨基羧酸的方法。 涉及以下步骤：（a）D，L，α-氨基羧酸被乙酰化; （b）将由此获得的N-乙酰基-D，L，α-氨基羧酸的混合物中存在的N-乙酰基-L-α-氨基羧酸酶促分解成L-氨基羧酸; （c）从混合物中分离出L-α-氨基羧酸，一定量的N-乙酰基-D（L）-α-氨基羧酸溶液和一定量的乙酸钠相当于L-氨基羧酸为 保留 和（d）N-乙酰基-D（L）-α-氨基羧酸被外消旋化并再循环用于酶分解。 涉及步骤（a）至（d）的已知提取方法具有产生大量盐的缺点。 具体来说，这些方法远远不能从理想方程中去除，根据其中百分之百的乙酸酐和D，L，α-氨基羧酸被转化成L-α-氨基羧酸和乙酸。 调节步骤（c）中保留的溶液，以获得基本上由N-乙酰基-D-（L）-α-氨基羧酸盐和游离乙酸与乙酸酯和游离N-乙酰基 - D（L）-α-氨基羧酸，通过蒸馏萃取乙酸，使得在电路中分离出L-α-氨基羧酸之后，使得形成为“母液”的溶液容易进料，并获得材料 平衡尽可能接近理想。