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    Monoclonal antibodies against tumor-associated antigens, a process for the preparation thereof and the use thereof
    15.
    再颁专利
    Monoclonal antibodies against tumor-associated antigens, a process for the preparation thereof and the use thereof 有权
    针对肿瘤相关抗原的单克隆抗体，其制备方法及其应用

    公开(公告)号：USRE37596E1

    公开(公告)日：2002-03-19

    申请号：US09333987

    申请日：1999-06-16

    申请人： Klaus Bosslet ,  Bernhard Auerbach ,  Helmut Peters

    发明人： Klaus Bosslet ,  Bernhard Auerbach ,  Helmut Peters

    IPC分类号： G01N33574

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K16/30 ,  C07K16/3023

    摘要： The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparation thereof, and to the antigens which can be defined and/or isolated with the aid of these antibodies or antibody fragments. The antibodies, antibody fragments and antigens can be used as diagnostic, aid, active substance or active substance carrier.

    摘要翻译： 本发明涉及与确定的肿瘤相关抗原（主要是小细胞肺癌（SCLC）），黑素瘤，神经母细胞瘤和神经外胚层起源的其他肿瘤结合的单克隆抗体（MAb）及其片段，用于制备杂交瘤细胞系 以及可以借助于这些抗体或抗体片段定义和/或分离的抗原。 抗体，抗体片段和抗原可用作诊断，辅助，活性物质或活性物质载体。

    Methods for removing heavy metals from aqueous solutions and for analysis
    20.
    发明授权
    Methods for removing heavy metals from aqueous solutions and for analysis 失效
    从水溶液中去除重金属和分析的方法

    公开(公告)号：US5908790A

    公开(公告)日：1999-06-01

    申请号：US463087

    申请日：1995-06-05

    申请人： Klaus Bosslet ,  Peter Hermentin ,  Gerhard Seemann

    发明人： Klaus Bosslet ,  Peter Hermentin ,  Gerhard Seemann

    IPC分类号： C02F1/62 ,  B01D39/00 ,  C07K16/44 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  G01N33/84

    CPC分类号： C07K16/44 ,  G01N33/5308 ,  G01N33/84

    摘要： The invention relates to monoclonal antibodies (mAB) which bind to water-soluble complexones such as ethylenediamine tetraacetate (EDTA) or diethylenetriamine pentaacetate (DTPA) with high specificity and avidity and retain their high avidity and specificity for these complexones after complexing of EDTA or DTPA with metal ions. These mAB can therefore be used, e.g. coupled on filters or other supports, for removing toxic heavy metals which are complexed with EDTA or DTPA. Furthermore, these mAB are suitable as components of immunoassays (RIA, ELISA etc.) for the quantitative determination of EDTA or DTPA in aqueous solutions.

    摘要翻译： 本发明涉及以高特异性和亲合力结合水溶性络合物例如乙二胺四乙酸（EDTA）或二亚乙基三胺五乙酸酯（DTPA）的单克隆抗体（mAB），并且在EDTA或DTPA复合后保持其对这些络合物的高亲合力和特异性 与金属离子。 因此，可以使用这些mAB。 耦合在过滤器或其他支持物上，用于去除与EDTA或DTPA复合的有毒重金属。 此外，这些mAB适用于在水溶液中定量测定EDTA或DTPA的免疫测定（RIA，ELISA等）的组分。