公开(公告)号：US08780593B2

公开(公告)日：2014-07-15

申请号：US13324434

申请日：2011-12-13

申请人： Chang-Yong Wang ,  Qing Chen

发明人： Chang-Yong Wang ,  Qing Chen

IPC分类号： H02M7/5387 ,  H02M7/797

CPC分类号： H02M7/5387 ,  H02J3/16 ,  H02J3/1807 ,  H02M1/42 ,  H02M7/487 ,  Y02B70/12 ,  Y02E40/34

摘要： A power compensation apparatus for a renewable energy system includes a plurality of converter modules positioned between any two phases of a three-phase AC electrical grid, each converter module including a plurality of inverter circuits connected in series. Each inverter circuit includes an energy storage unit for providing a direct current (DC) voltage; a capacitor connected to the energy storage unit; and an H-bridge circuit converting the DC voltage into an alternating current (AC) voltage. The converter modules perform reactive power compensation and active power regulation on the electrical grid in a delta connection. A plurality of converter modules are respectively positioned between any two phases of the electrical grid in a delta connection, so as to keep the voltage of the electrical grid continuously stable when the voltage of the electrical grid fluctuates, and also compensate load current when system load is not balanced.

摘要翻译： 用于可再生能源系统的功率补偿装置包括位于三相交流电网的任何两相之间的多个转换器模块，每个转换器模块包括串联连接的多个逆变器电路。 每个逆变器电路包括用于提供直流（DC）电压的能量存储单元; 连接到能量存储单元的电容器; 以及将DC电压转换成交流（AC）电压的H桥电路。 转换器模块在三角形连接中对电网进行无功功率补偿和有功功率调节。 多个转换器模块分别位于三角形连接中的电网的任何两相之间，以便当电网的电压波动时使电网的电压持续稳定，并且还在系统负载时补偿负载电流 不平衡

公开(公告)号：US08633186B2

公开(公告)日：2014-01-21

申请号：US12663634

申请日：2008-06-03

申请人： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Xiaodong Li ,  Feng Zhang ,  Guy Servant ,  Qing Chen ,  Vincent Darmohusodo ,  Richard Fine ,  Joseph R. Fotsing ,  Jeffrey Robert Hammaker ,  Xinshan Kang ,  Rachel D. A. Kimmich ,  Boris Klebansky ,  Haitian Liu ,  Goran Petrovic ,  Marketa Rinnova ,  Sara Adamski-Werner ,  Jeffrey Yamamoto ,  Hong Zhang ,  Albert Zlotnik ,  Karen Zoller

发明人： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Xiaodong Li ,  Feng Zhang ,  Guy Servant ,  Qing Chen ,  Vincent Darmohusodo ,  Richard Fine ,  Joseph R. Fotsing ,  Jeffrey Robert Hammaker ,  Xinshan Kang ,  Rachel D. A. Kimmich ,  Boris Klebansky ,  Haitian Liu ,  Goran Petrovic ,  Marketa Rinnova ,  Sara Adamski-Werner ,  Jeffrey Yamamoto ,  Hong Zhang ,  Albert Zlotnik ,  Mark Zoller

IPC分类号： C07D239/95 ,  C07D285/16 ,  A61K31/517 ,  A61K31/54

CPC分类号： A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  C07D239/80 ,  C07D239/93 ,  C07D239/95 ,  C07D239/96 ,  C07D285/15 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/04 ,  C07D513/20 ,  C07H17/00 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/04 ,  G06F19/16 ,  G06F19/18

摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

摘要翻译： 本发明包括用于鉴定化学感受器及其配体的调节剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获区域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体 及其配体。 本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。 此外，本发明包括含有化学感应受体调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体改性剂增强可摄入组合物的甜味或治疗与化学感觉受体相关的病症的方法。 此外，本发明包括制备化学感受器及其配体的改性剂的方法。

公开(公告)号：US20130209489A1

公开(公告)日：2013-08-15

申请号：US13816894

申请日：2011-08-15

申请人： Huiquan Han ,  Taruna Arora ,  Qing Chen ,  Hsieng Sen Lu ,  Xiaolan Zhou

发明人： Huiquan Han ,  Taruna Arora ,  Qing Chen ,  Hsieng Sen Lu ,  Xiaolan Zhou

IPC分类号： C07K16/26

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/466

摘要： There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60.

摘要翻译： 公开了选择性肌生成抑制素拮抗剂（包括抗体），编码它们的核酸，以及制备和使用它们的方法。 识别位置21至31位置50至60附近的构象表位的中和抗体。

公开(公告)号：US08505844B2

公开(公告)日：2013-08-13

申请号：US11992144

申请日：2006-08-03

申请人： Qing Chen ,  Jörg Reh

发明人： Qing Chen ,  Jörg Reh

IPC分类号： B65H23/18

CPC分类号： B65H59/384 ,  B65H26/00 ,  B65H26/02 ,  B65H2511/529

摘要： Described is a method for operating a winding machine used for winding up and/or unwinding a winding material, said winding machine comprising a device for controlling and/or regulating the winding process. A variable value is monitored that concerns a machine state and/or a change in the winding material, and at least one parameter of said controlling and/or regulating device is modified in accordance with the change identified.

摘要翻译： 描述了用于操作用于卷绕和/或展开卷绕材料的卷绕机的方法，所述卷绕机包括用于控制和/或调节卷绕过程的装置。 监测涉及机器状态和/或卷绕材料变化的可变值，并且根据所识别的变化修改所述控制和/或调节装置的至少一个参数。

公开(公告)号：US07928111B2

公开(公告)日：2011-04-19

申请号：US11836074

申请日：2007-08-08

申请人： Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

发明人： Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

IPC分类号： A61K31/519

CPC分类号： C07D513/04 ,  A23L2/39 ,  A23L2/60 ,  A23L27/30 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/88 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D285/16 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566

摘要： The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors: These compounds are useful as sweet taste enhancers in comestible or medicinal compositions. The present invention also provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

摘要翻译： 本发明提供了包含式（IIc）的取代的噻吩并嘧啶酮衍生物作为调节化学感应受体的配体的化合物：这些化合物可用作食用或药用组合物中的甜味增强剂。 本发明还提供了用于鉴定化学感应受体及其配体的调节剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能够 调节化学感受器及其配体。

公开(公告)号：US6005377A

公开(公告)日：1999-12-21

申请号：US932263

申请日：1997-09-17

申请人： Qing Chen ,  Anatoly Feygenson ,  Ashraf Wagih Lotfi ,  Kenneth John Timm

发明人： Qing Chen ,  Anatoly Feygenson ,  Ashraf Wagih Lotfi ,  Kenneth John Timm

IPC分类号： H02M3/157 ,  G05F1/40 ,  G05F1/575

CPC分类号： H02M3/157

摘要： A programmable controller for switch-mode power converters that operates in a digital domain without reliance on operation software and the ability to vastly reduce or eliminate analog circuitry. The digital controller is re-programmable. In one embodiment, the substantially digital portion of the controller is a Field Programmable Gate Array that controls operation of the converter by generally converting an analog reference signal(s) (e.g. the voltage output) into the digital domain. The controller then can perform distributed arithmetic to generate a square wave signal capable of controlling at least a main switch of the converter. The present invention can, if desired, essentially eliminate analog controllers in power conversion systems such as switch-mode converters.

摘要翻译： 用于开关模式电源转换器的可编程控制器，可在数字域中运行，而不依赖于操作软件，并能够大幅度减少或消除模拟电路。 数字控制器可重新编程。 在一个实施例中，控制器的基本数字部分是现场可编程门阵列，其通过将模拟参考信号（例如，电压输出）通常转换成数字域来控制转换器的操作。 然后，控制器可以执行分布式算术以产生能够至少控制转换器的主开关的方波信号。 如果需要，本发明可以基本上消除诸如开关模式转换器的功率转换系统中的模拟控制器。

公开(公告)号：US08586733B2

公开(公告)日：2013-11-19

申请号：US13056843

申请日：2009-07-29

申请人： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

发明人： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

IPC分类号： C07D285/16 ,  C07C255/60

CPC分类号： C07D285/16 ,  C01B21/096 ,  C07C231/02 ,  C07C231/14 ,  C07C235/20 ,  C07C237/44 ,  C07C253/30 ,  C07C255/54 ,  C07C255/57 ,  C07C255/59 ,  C07C303/40 ,  C07C307/10

摘要： The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.

摘要翻译： 本发明包括用于制备具有结构式（I）的化合物的方法/方法和中间体：其中X是烷基，取代的烷基，烯基，取代的烯基，杂烷基，取代的杂烷基，杂烯基或取代的杂烯基。

公开(公告)号：US20130030159A1

公开(公告)日：2013-01-31

申请号：US13550447

申请日：2012-07-16

申请人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

发明人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

IPC分类号： C07K16/26

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

公开(公告)号：US08227434B1

公开(公告)日：2012-07-24

申请号：US10983009

申请日：2004-11-04

申请人： William S. Dalton ,  Lori Hazlehurst ,  Qing Chen

发明人： William S. Dalton ,  Lori Hazlehurst ,  Qing Chen

IPC分类号： A61K31/70

CPC分类号： A61K31/7088 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/31

摘要： The subject invention pertains to materials and methods for treating oncological disorders. The subject invention also pertains to materials and methods for preventing or reducing the development by cancer cells of resistance to an anticancer therapy, such as chemotherapy, radiotherapy and/or immunotherapy. In one embodiment, a patient is treated with an agent that inhibits cholesterol synthesis or that prevents or reduces the increase in cholesterol synthesis observed in therapy-resistant cancer cells. In another embodiment, a patient is treated with an agent that increases the expression, activity, or amount of a Bim protein in a cell. In another embodiment, a patient is treated with an agent to inhibit or reduce cancer cell adhesion to extracellular matrices or stromal cells. In another embodiment, a patient is treated with an agent to inhibit expression of a gene of function of a protein of the FANC/BRCA pathway. In a further embodiment, a patient is treated with an agent to prevent or reduce the DNA crosslink repair function of a cell.

摘要翻译： 本发明涉及用于治疗肿瘤疾病的材料和方法。 本发明还涉及用于预防或减少癌细胞对化疗，放射治疗和/或免疫治疗等抗癌治疗的抗性的发展的材料和方法。 在一个实施方案中，患者用抑制胆固醇合成的药物或用于预防或减少在耐药性癌细胞中观察到的胆固醇合成的增加来治疗。 在另一个实施方案中，用增加细胞中Bim蛋白的表达，活性或量的试剂治疗患者。 在另一个实施方案中，用药剂治疗患者以抑制或减少癌细胞对细胞外基质或基质细胞的粘附。 在另一个实施方案中，患者用药物治疗以抑制FANC / BRCA途径的蛋白质的功能基因的表达。 在另一个实施方案中，用试剂治疗患者以预防或减少细胞的DNA交联修复功能。

公开(公告)号：US20090267053A1

公开(公告)日：2009-10-29

申请号：US12422074

申请日：2009-04-10

申请人： Lianmao Peng ,  Xuelei Liang ,  Zhiyong Zhang ,  Sheng Wang ,  Qing Chen

发明人： Lianmao Peng ,  Xuelei Liang ,  Zhiyong Zhang ,  Sheng Wang ,  Qing Chen

IPC分类号： H01L29/66

CPC分类号： H01L27/15 ,  B82Y10/00 ,  H01L33/34 ,  H01L51/0048 ,  H01L51/0545 ,  H01L51/105

摘要： A carbon nano-tube based photoelectric device includes a substrate and a carbon nanotube (CNT) over the substrate. The CNT comprises a first end and a second end, wherein the CNT has a CNT work function. A high work-function electrode over the substrate is in electric contact with the first end of the CNT. The high work-function electrode has a first work function higher than the CNT work function. A low work-function electrode over the substrate is in electric contact with the second end of the CNT. The low work-function electrode has a second work function lower than the CNT work function. The CNT can form a conductive channel between the high work-function electrode and the low work-function electrode. The carbon nano-tube based photoelectric device also includes a dielectric material is in contact with a side surface of the CNT and a conductive material in contact with the dielectric material.

摘要翻译： 基于碳纳米管的光电装置包括在基板上的基板和碳纳米管（CNT）。 CNT包括第一端和第二端，其中CNT具有CNT功能。 衬底上的高功函电极与CNT的第一端电接触。 高功函电极具有高于CNT功能的第一功函数。 衬底上的低功函电极与CNT的第二端电接触。 低功函电极具有低于CNT功能的第二功能。 CNT可以在高功函电极和低功函电极之间形成导电沟道。 基于碳纳米管的光电装置还包括与CNT的侧表面接触的电介质材料和与电介质材料接触的导电材料。