公开(公告)号：US10786674B2

公开(公告)日：2020-09-29

申请号：US15064337

申请日：2016-03-08

Applicant: Medtronic, Inc.

Inventor： Jianping Wu ,  Dwight E. Nelson ,  Gabriela C. Molnar

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/00

Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

公开(公告)号：US20170259064A1

公开(公告)日：2017-09-14

申请号：US15064337

申请日：2016-03-08

Applicant: Medtronic, Inc.

Inventor： Jianping Wu ,  Dwight E. Nelson ,  Gabriela C. Molnar

IPC: A61N1/36 ,  A61N1/05

Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

公开(公告)号：US20140371599A1

公开(公告)日：2014-12-18

申请号：US14104057

申请日：2013-12-12

Applicant: Medtronic, Inc.

Inventor： Jianping Wu ,  Chih Lai ,  Dwight E. Nelson

IPC: A61B5/00

CPC classification number: A61B5/0077 ,  A61B5/0022 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/08 ,  A61B5/1114 ,  A61B5/1124 ,  A61B5/1128 ,  A61B5/4082 ,  A61B5/4803 ,  A61B5/4809 ,  A61B5/4836 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/7264 ,  A61B5/743 ,  A61N1/36 ,  G06T7/254 ,  G06T7/262 ,  G06T2207/10016 ,  G06T2207/30196

Abstract: Devices, systems, and techniques for analyzing video information to objectively identify patient behavior are disclosed. A system may analyze obtained video information of patient motion during a period of time to track one or more anatomical regions through a plurality of frames of the video information and calculate one or more movement parameters of the one or more anatomical regions. The system may also compare the one or more movement parameters to respective criteria for each of a plurality of predetermined patient behaviors and identify the patient behaviors that occurred during the period of time. In some examples, a device may control therapy delivery according to the identified patient behaviors and/or sensed parameters previously calibrated based on the identified patient behaviors.

Abstract translation: 公开了用于分析视频信息以客观地识别患者行为的设备，系统和技术。 系统可以在一段时间内分析获得的患者运动的视频信息，以通过视频信息的多个帧跟踪一个或多个解剖区域，并且计算一个或多个解剖区域的一个或多个运动参数。 系统还可以将一个或多个运动参数与多个预定患者行为中的每一个的相应标准进行比较，并且识别在该时间段期间发生的患者行为。 在一些示例中，装置可以根据所识别的患者行为和/或基于所识别的患者行为预先校准的感测参数来控制治疗递送。

公开(公告)号：US08761890B2

公开(公告)日：2014-06-24

申请号：US13748633

申请日：2013-01-24

Applicant: Medtronic, Inc.

Inventor： Rahul Gupta ,  Steven M. Goetz ,  Maciej T. Lazarewicz ,  Gabriela C. Molnar ,  Dwight E. Nelson ,  Jianping Wu

IPC: A61N1/36

CPC classification number: A61N1/36067 ,  A61N1/36082 ,  A61N1/36164 ,  A61N1/36185 ,  A61N1/37247

Abstract: In one example, the disclosure relates to a method comprising receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site, and determining, via one or more processors, a volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site.

Abstract translation: 在一个示例中，本公开涉及一种方法，包括接收限定电刺激的至少一个电刺激参数值，用于经由一个或多个电极递送至组织部位，以及经由一个或多个处理器确定子激活阈值的量 对组织从电刺激递送到组织部位的影响。

公开(公告)号：US08670830B2

公开(公告)日：2014-03-11

申请号：US13827537

申请日：2013-03-14

Applicant: Medtronic, Inc.

Inventor： David L. Carlson ,  Randy M. Jensen ,  Timothy J. Denison ,  Jianping Wu ,  Gabriela C. Molnar ,  Scott R. Stanslaski ,  William J. Marks, Jr.

IPC: A61N1/18

CPC classification number: A61N1/36067 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/37247

Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。 在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。 也可以使用其他频带特性来选择刺激电极组合。

公开(公告)号：US20130268019A1

公开(公告)日：2013-10-10

申请号：US13748633

申请日：2013-01-24

Applicant: MEDTRONIC, INC.

Inventor： Rahul Gupta ,  Steven M. Goetz ,  Maciej T. Lazarewicz ,  Gabriela C. Molnar ,  Dwight E. Nelson ,  Jianping Wu

IPC: A61N1/36

CPC classification number: A61N1/36067 ,  A61N1/36082 ,  A61N1/36164 ,  A61N1/36185 ,  A61N1/37247

Abstract: In one example, the disclosure relates to a method comprising receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site, and determining, via one or more processors, a volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site.

Abstract translation: 在一个示例中，本公开涉及一种方法，包括接收限定电刺激的至少一个电刺激参数值，用于经由一个或多个电极递送至组织部位，以及经由一个或多个处理器确定子激活阈值的量 对组织从电刺激递送到组织部位的影响。

公开(公告)号：US12178603B2

公开(公告)日：2024-12-31

申请号：US17394355

申请日：2021-08-04

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Jianping Wu ,  Rahul Gupta ,  Yan Zhao

IPC: A61B5/00 ,  A61B5/374 ,  A61N1/36

Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity.

公开(公告)号：US20210001126A1

公开(公告)日：2021-01-07

申请号：US17028489

申请日：2020-09-22

Applicant: Medtronic, Inc.

Inventor： Jianping Wu ,  Dwight E. Nelson ,  Gabriela C. Molnar

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/00

Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

公开(公告)号：US20150265207A1

公开(公告)日：2015-09-24

申请号：US14733349

申请日：2015-06-08

Applicant: Medtronic, Inc.

Inventor： Jianping Wu ,  Gregory F. Molnar ,  Gabriela C. Molnar ,  Timothy J. Denison

IPC: A61B5/00 ,  A61B5/04 ,  A61M5/172 ,  A61B5/0205 ,  A61B5/0402 ,  A61N1/36 ,  A61B5/0478 ,  A61B5/11

CPC classification number: A61B5/4812 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/024 ,  A61B5/04014 ,  A61B5/04015 ,  A61B5/0402 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4082 ,  A61B5/4839 ,  A61M5/1723 ,  A61M21/02 ,  A61M2005/1726 ,  A61M2021/0072 ,  A61M2205/3523 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/08 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/42 ,  A61M2230/50 ,  A61M2230/60 ,  A61M2230/63 ,  A61M2230/65 ,  A61N1/36078 ,  A61N1/36139 ,  G06F19/3481 ,  G16H40/63

Abstract: Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.

公开(公告)号：US20140358024A1

公开(公告)日：2014-12-04

申请号：US13955367

申请日：2013-07-31

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Jianping Wu ,  Rahul Gupta ,  Yan Zhao

IPC: A61B5/04 ,  A61B5/0478 ,  A61B5/00 ,  A61N1/36

CPC classification number: A61B5/04014 ,  A61B5/048 ,  A61B5/4064 ,  A61B5/4833 ,  A61B5/7282 ,  A61N1/36139

Abstract: In some examples, a processor determines a patient state based on activity of a bioelectrical brain signal of a patient in one or more frequency sub-bands of a frequency band of interest. For example, a processor may determine a patient state based on the power level of a bioelectrical brain signal of the patient in one or more frequency sub-bands of a frequency band, or based on a spectral pattern of a bioelectrical brain signal in a frequency band, such as a shift in a power distribution between sub-bands, a change in the peak frequency within one or more sub-bands, a pattern of the power distribution over one or more frequency sub-bands, or a width or a variability of one or more sub-bands exhibiting a relatively high or low level of activity

Abstract translation: 在一些示例中，处理器基于感兴趣的频带的一个或多个频率子带中的患者的生物电脑信号的活动来确定患者状态。 例如，处理器可以基于频带的一个或多个频率子带中的患者的生物电脑信号的功率水平，或者基于频率的生物电脑信号的频谱图来确定患者状态 频带，例如子频带之间的功率分配的偏移，一个或多个子带内的峰值频率的变化，一个或多个频率子带上的功率分布的模式，或宽度或变化性 的一个或多个子带表现出相对较高或低水平的活性