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公开(公告)号：US06664091B2
公开(公告)日：2003-12-16
申请号：US10023515
申请日：2001-12-18
IPC分类号： C12N918
CPC分类号： C12N9/18
摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。 本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人转基因动物。 本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。 还提供了利用本发明组合物的诊断方法。
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12.发明授权21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, H1983, M1983, 38555 or 593 molecules and uses therefor 失效21910,5563,4505,2504,15977,14760,25501,17903,3720,21529,26176,26343,5666,18610,33217,26967，H1983，M1983,38555或593分子及其用途公开(公告)号：US07696316B2
公开(公告)日：2010-04-13
申请号：US11583766
申请日：2006-10-19
申请人： Rosana Kapeller-Libermann , John Joseph Hunter , Rachel E. Meyers , Laura A. Rudolph-Owen , Rory A. J. Curtis , Peter J. Olandt , Fong-Ying Tsai , Katherine M. Galvin , Miyoung Chun , Mark J. Williamson , Inmaculada Silos-Santiago , Rajasekhar Bandaru
发明人： Rosana Kapeller-Libermann , John Joseph Hunter , Rachel E. Meyers , Laura A. Rudolph-Owen , Rory A. J. Curtis , Peter J. Olandt , Fong-Ying Tsai , Katherine M. Galvin , Miyoung Chun , Mark J. Williamson , Inmaculada Silos-Santiago , Rajasekhar Bandaru
CPC分类号： C07K14/47 , A01K2217/05 , C12N9/1235
摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸 分子。 本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体 和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176， 已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。 本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白， 抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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13.发明授权Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263 有权使用羧肽酶Z鉴定为8263的泌尿系统疾病的方法和组合物公开(公告)号：US07258971B2
公开(公告)日：2007-08-21
申请号：US10757262
申请日：2004-01-14
CPC分类号： C07K14/47
摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of Carboxypeptidase Z, identified as “8263” gene in tissues relating to urological disorder, relative to their expression in normal, or non-urological disorder disease states, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.
摘要翻译： 本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。 具体而言，本发明鉴定了相对于在正常或非泌尿疾病疾病状态下的表达，和/或响应于与泌尿系疾病相关的操作相关的与泌尿系疾病相关的组织中鉴定为“8263”基因的羧肽酶Z的差异表达 泌尿系统疾病 本发明描述了各种泌尿疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。 本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。
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公开(公告)号：US07081344B2
公开(公告)日：2006-07-25
申请号：US10001227
申请日：2001-11-30
IPC分类号： G01N33/53 , G01N33/567 , C12N9/64
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01001
摘要： The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-2 gene has been introduced or disrupted. The invention still further provides isolated COE-2 proteins, fusion proteins, antigenic peptides and anti-COE-2 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为COE-2核酸分子，其编码新的羧酸酯酶家族成员。 本发明还提供反义核酸分子，含有COE-2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及其中引入或破坏了COE-2基因的非人转基因动物。 本发明还进一步提供分离的COE-2蛋白，融合蛋白，抗原肽和抗COE-2抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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15.发明申请Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084Fl and 67084alt molecules and uses therefor 审中-公开新颖的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2delta-4,8099,46455,5414,53763,97076,97102,44181,67084F1和67084altalt分子， 用它公开(公告)号：US20080032289A1
公开(公告)日：2008-02-07
申请号：US11050947
申请日：2005-02-04
IPC分类号： C07K14/435 , C07K16/18 , C12N1/00 , C12N15/12 , C12N15/63 , C12N5/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： G01N33/57415 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K16/18 , C07K2319/00 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/6872 , G01N2800/32 , G01N2800/325 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, which encode novel ion channel family molecules, including calcium channels, potassium channels, and NMDA receptors. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt gene has been introduced or disrupted. The invention still further provides isolated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt polypeptides, fusion polypeptides, antigenic peptides and anti-TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，称为TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099， 46455,55414,53763,97076,97102,44181,67084FL和67084alt核酸分子，其编码新的离子通道家族分子，包括钙通道，钾通道和NMDA受体。 本发明还提供反义核酸分子，含有TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ- 4,8099,46455,54144,53763,97076,97102,44181,67084FL和67084alt核酸分子，其中引入了表达载体的宿主细胞，以及非人转基因动物，其中TWIK-6，TWIK-7 ，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt基因 已被引入或中断。 本发明还进一步提供了分离的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2ΔΔ4,8099,46455,5444 ，53763,97076,97102,44181,67084FL和67084alt多肽，融合多肽，抗原肽和抗TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9， 3Δ-4，8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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16.发明授权公开(公告)号：US07094589B2
公开(公告)日：2006-08-22
申请号：US10674636
申请日：2003-09-29
CPC分类号： C12N9/18
摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。 本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人类转基因动物。 本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06586205B1
公开(公告)日：2003-07-01
申请号：US09585876
申请日：2000-06-01
IPC分类号： C12P2106
CPC分类号： C07K14/705 , A61K38/00
摘要： Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion proteins, antigenic peptides, and anti-GPCR-like antibodies. The invention also provides GPCR-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GPCR-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了新的GPCR样多肽，蛋白质和核酸分子。 除了分离的全长GPCR样蛋白之外，本发明还提供了分离的GPCR样融合蛋白，抗原肽和抗GPCR样抗体。 本发明还提供了GPCR样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经导入或破坏了GPCR样基因的非人转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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18.发明申请NOVEL 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 AND 26908 MOLECULES AND USES THEREFOR 审中-公开NO 18636,2466,43238,1983,52881,29898,45449,50289,52872和26908分子及其用途公开(公告)号：US20110165147A1
公开(公告)日：2011-07-07
申请号：US13037699
申请日：2011-03-01
IPC分类号： A61K39/395 , C07H21/04 , C12N5/10 , C07K14/00 , C07K16/00 , C12P21/02 , C12Q1/68 , G01N33/00 , G01N33/53 , A61K38/00 , A61K38/16 , A61K31/711 , A61P43/00
CPC分类号： C07K14/47 , C07K14/705 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 gene has been introduced or disrupted. The invention still further provides isolated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 proteins, fusion proteins, antigenic peptides and anti-18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为18636,2466,43238,1983,52881,29898,45449,50289,52872和26908核酸分子。 本发明还提供反义核酸分子，含有18636,2466,43238,1983,52881,29898,45449,502892,5282和26908核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人转基因 引入或破坏18636,2466,43238,1983,52881,2398,45449,50289,52872或26908基因的动物。 本发明还进一步提供了分离的18636,2466,43238,1983,52881,2398,45449,50289,52872或26908蛋白，融合蛋白，抗原肽和抗-18636,2466,43238,1983,52881,29898,45449,50289 ，52872或26908抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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19.发明申请Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor 审中-公开小分子18636,2446,43238,1983,52881,29898,45449,50289,52872和26908分子及其用途公开(公告)号：US20090226451A1
公开(公告)日：2009-09-10
申请号：US12387287
申请日：2009-04-28
IPC分类号： A61K39/395 , C12N15/11 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , G01N33/00 , G01N33/68 , G01N33/566 , C12Q1/68 , A61K38/02 , A61K38/16 , A61K31/7088
CPC分类号： C07K14/47 , C07K14/705 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 gene has been introduced or disrupted. The invention still further provides isolated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 proteins, fusion proteins, antigenic peptides and anti-18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为18636,2466,43238,1983,52881,29898,45449,50289,52872和26908核酸分子。 本发明还提供反义核酸分子，含有18636,2466,43238,1983,52881,29898,45449,502892,5282和26908核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人转基因 引入或破坏18636,2466,43238,1983,52881,2398,45449,50289,52872或26908基因的动物。 本发明还进一步提供了分离的18636,2466,43238,1983,52881,2398,45449,50289,52872或26908蛋白，融合蛋白，抗原肽和抗-18636,2466,43238,1983,52881,29898,45449,50289 ，52872或26908抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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20.发明申请Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921, and 33751 molecules and uses therefor 审中-公开小分子18607,15603,69318,12303,48000,52202,5333,35554,57301,58324,55063,52991,59914,59921和33751分子及其用途公开(公告)号：US20090226449A1
公开(公告)日：2009-09-10
申请号：US12381748
申请日：2009-03-16
申请人： Maria A. Glucksmann , Rory A.J. Curtis , Jose M. Lora , Katherine M. Galvin , Inmaculada Silos-Santiago
发明人： Maria A. Glucksmann , Rory A.J. Curtis , Jose M. Lora , Katherine M. Galvin , Inmaculada Silos-Santiago
IPC分类号： A61K39/395 , C12N15/12 , C12N5/10 , C07K14/47 , C07K16/18 , C12P21/02 , C12Q1/68 , G01N33/566 , A61K38/17 , A61K31/7105 , A61K38/48 , A61P35/00 , A61P43/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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