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公开(公告)号：US20190327964A1
公开(公告)日：2019-10-31
申请号：US16349800
申请日：2017-11-20
Applicant: Massachusetts Institute of Technology
Inventor： T. Alan Hatton , Timothy Kuan-Ta Lu , Paul Brown , Cesar de la Fuente Nunez , Sahag Voskian
Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.
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公开(公告)号：US20190024099A1
公开(公告)日：2019-01-24
申请号：US15757530
申请日：2016-09-07
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Sara da Luz Areosa Cleto
Abstract: Compositions and methods using shufflon recombinases are presented for use in generating genetic diversity in molecules of interest.
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公开(公告)号：US20180305703A1
公开(公告)日：2018-10-25
申请号：US15924045
申请日：2018-03-16
Inventor： Timothy Kuan-Ta Lu , Robert James Citorik , James Collins , Russell-John Krom
CPC classification number: C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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公开(公告)号：US20180155721A1
公开(公告)日：2018-06-07
申请号：US15795510
申请日：2017-10-27
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Sebastien Lemire , Andrew C. Yang , Kevin M. Yehl
IPC: C12N15/113 , C07K14/005 , A61P31/04
CPC classification number: C12N15/113 , A61P31/04 , C07K14/005 , C12N2320/32 , C12N2330/30 , C12N2795/00021 , C12N2795/00032 , C12N2795/14122 , C12N2795/14132 , G01N33/56916
Abstract: Disclosed herein are novel synthetic bacteriophages and bacteriophage compositions, methods of production thereof, and therapeutic uses thereof.
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公开(公告)号：US20180155400A1
公开(公告)日：2018-06-07
申请号：US15579631
申请日：2016-06-03
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Sara da Luz Areosa Cleto
IPC: C07K14/245 , C12N15/52 , C12P21/00 , C12N9/52 , C40B40/06
Abstract: Provided herein are synthetic pathways from Escherichia coli and Vibrio cholerae genes for the production of new, synthetic nonribosomal peptides, and methods and compositions comprising the same. Some aspects of the present disclosure are directed to modified bacterial cells comprising a compressed biosynthetic pathway that comprises (a) biosynthetic genes obtained from one species encoding enzymes active in the bioassembly of a nonribosomal molecule, (b) biosynthetic genes obtained from another species encoding enzymes active in the bioassembly of a nonribosomal molecule that is different from the nonribosomal molecule of (a). In some embodiments, the biosynthetic genes of (a) are Escherichia coli biosynthetic genes and may include entD gene, an entC gene, an entE gene, an entB gene and an entA gene. In some embodiments, the biosynthetic genes of (b) are Vibrio cholera biosynthetic genes and may include a vibH gene and a vibF gene.
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Patent Agency Ranking
公开(公告)号：US20170362599A1
公开(公告)日：2017-12-21
申请号：US15535804
申请日：2015-12-22
Applicant: Massachusetts Institute of Technology
Inventor： Ramez Daniel , Timothy Kuan-Ta Lu , Jacob Rosenblum Rubens
CPC classification number: C12N15/635 , C12N15/63 , C12N15/70 , C12Q1/6897
Abstract: Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.
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公开(公告)号：US20170335334A1
公开(公告)日：2017-11-23
申请号：US15521943
申请日：2015-10-29
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Peter A. Carr , Bijan Zakeri
CPC classification number: C12N15/74 , C12N15/87 , C12Q1/68 , G16B40/00 , C12Q2521/507 , C12Q2563/185
Abstract: The disclosure relates to the use of steganographic methods to camouflage information encoded on nucleic acids. Specifically, the method comprising preparing a pool of recombinant nucleic acid constructs, wherein at least one of the constnjcts comprises the nucleic acid sequence to be camouflaged and wherein the pool is heterogeneous with respect to the orientation of the nucleic acid sequence to be camouflaged, and the information is camouflaged using genetic recombination.
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公开(公告)号：US09617522B2
公开(公告)日：2017-04-11
申请号：US14478657
申请日：2014-09-05
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Hiroki Ando , Sebastien Lemire
CPC classification number: C12N7/00 , C12N7/02 , C12N15/81 , C12N2795/00011 , C12N2795/00021
Abstract: Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.
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公开(公告)号：US11591604B2
公开(公告)日：2023-02-28
申请号：US15580859
申请日：2016-06-10
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Mark K. Mimee , Christopher Voigt , Alex C. Tucker
IPC: A61K35/741 , C12N15/74 , A61K48/00 , C12N9/12 , C12N9/22 , C12N9/96 , C12N15/11 , C12N15/67 , C12N15/90
Abstract: Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
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公开(公告)号：US20220033830A1
公开(公告)日：2022-02-03
申请号：US17189113
申请日：2021-03-01
Inventor： Timothy Kuan-Ta Lu , Robert James Citorik , James Collins , Russell-John Krom
Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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