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    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel
    11.
    发明授权
    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel 失效
    含有聚（N-乙烯基吡咯烷酮）聚合物水凝胶的聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法

    公开(公告)号：US5662960A

    公开(公告)日：1997-09-02

    申请号：US384711

    申请日：1995-02-01

    Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    IPC: A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  B05D1/36 ,  B05D7/00 ,  B05D7/02 ,  B05D7/16 ,  B05D7/24 ,  C08G18/10 ,  C08J7/00 ,  C08J7/04 ,  B05D3/10 ,  B05D3/04 ,  C23C14/02

    CPC classification number: B05D7/52 ,  A61L29/085 ,  A61L31/10 ,  B05D7/02 ,  B05D7/16 ,  C08G18/10 ,  C08G2210/00 ,  C08G2270/00

    Abstract: A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

    Abstract translation: 一种制备聚氨酯 - 聚脲聚合物水凝胶和聚（N-乙烯基吡咯烷酮）聚合物水凝胶的混合水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这种应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长时间使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

    Drug delivery guidewire
    12.
    发明授权
    Drug delivery guidewire 失效
    药物输送导丝

    公开(公告)号：US5569197A

    公开(公告)日：1996-10-29

    申请号：US360488

    申请日：1994-12-21

    Applicant: Michael N. Helmus ,  Michael R. Forman

    Inventor： Michael N. Helmus ,  Michael R. Forman

    IPC: A61M25/01 ,  A61F2/06 ,  A61F2/84 ,  A61M25/00 ,  A61M25/09 ,  A61M29/02 ,  A61M29/00

    CPC classification number: A61M25/09 ,  A61F2/95 ,  A61M2025/091 ,  A61M2025/09175 ,  A61M25/007 ,  A61M25/104

    Abstract: This invention relates to a drug delivery device having a hollow tube which is configured to serve as a guide wire for intraluminal procedures. The distal portion of the tube has at least one opening which has a diameter suitable for the infusion of a drug formulation therethrough. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this drug delivery device in thrombolytic and other intraluminal procedures.

    Abstract translation: 本发明涉及具有中空管的药物输送装置，该中空管构造成用作管腔内手术的导丝。 管的远端部分具有至少一个开口，其具有适合于通过其注入药物制剂的直径。 该管优选由诸如镍 - 钛合金的超弹性材料形成。 本发明还涉及在血栓溶解和其它腔内手术中使用该药物递送装置的各种方法。

    Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration
    13.
    发明授权
    Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration 失效
    药物输送和扩张药物输送导管在快速交换配置中

    公开(公告)号：US5514092A

    公开(公告)日：1996-05-07

    申请号：US287121

    申请日：1994-08-08

    Applicant: Michael R. Forman ,  Lori L. Stowell

    Inventor： Michael R. Forman ,  Lori L. Stowell

    IPC: A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

    CPC classification number: A61M25/104 ,  A61M25/1011 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1079

    Abstract: Catheters for drug delivery or for both dilatation and drug delivery are provided with a guide wire lumen terminating within the catheter shaft and having an opening through the catheter shaft to enable a guide wire to exit the catheter shaft substantially distal to the proximal end of the catheter. In one embodiment, drug delivery ports are provided between occlusion balloons. In another embodiment, a dilatation balloon is also provided between the occlusion balloons. In another embodiment, a double layered balloon is provided to simultaneously dilatate the stenosis and deliver medication to the site. Alternatively, a balloon can be provided which only delivers medication.

    Abstract translation: 用于药物递送或用于扩张和药物递送的导管设置有终止于导管轴内的导丝管腔，并且具有穿过导管轴的开口，以使引导线能够基本上远离导管的近端离开导管轴 。 在一个实施例中，药物输送端口设置在闭塞气囊之间。 在另一个实施例中，还在闭塞气囊之间设置扩张气囊。 在另一个实施方案中，提供双层气囊以同时扩张狭窄并将药物递送至部位。 或者，可以提供仅输送药物的气囊。

    Gross pathology breast map
    15.
    发明授权
    Gross pathology breast map 有权
    大病理乳腺图

    公开(公告)号：US07571728B2

    公开(公告)日：2009-08-11

    申请号：US10820433

    申请日：2004-04-08

    Applicant: Michael R. Forman ,  Darius Francescatti

    Inventor： Michael R. Forman ,  Darius Francescatti

    IPC: A61B19/00

    CPC classification number: A61B10/0041 ,  A61B6/502 ,  A61B2090/3908

    Abstract: A system and method to position and orient an excised breast tissue specimen on a support structure in a duplicate anatomic orientation relative to the operated breast is provided. One embodiment of the system includes an anatomically representative map of the breast under investigation. The system allows a surgeon to suture, ink, or otherwise fix the excised specimen on the map in accordance to its original position and orientation in the operated breast or organ. A radiogram of the excised specimen can be taken that shows the location of calcifications on a grid with radiopaque markers. The system allows a pathologist to cut through the specimen utilizing the map as a template in order to perform histological analysis and correlate the position and orientation of each slice to its anatomic position in the breast and thereby direct a precise and anatomically accurate re-excision by the surgeon if so required.

    Abstract translation: 提供了一种系统和方法，用于将切除的乳房组织样本定位和定向在相对于被操作的乳房的重复解剖方向的支撑结构上。 该系统的一个实施例包括正在调查的乳房的解剖学代表性的地图。 该系统允许外科医生根据其在操作的乳房或器官中的原始位置和取向缝合，油墨或以其他方式将切除的样本固定在地图上。 可以采取切除标本的放射线图，显示在具有不透射线标记的网格上钙化的位置。 该系统允许病理学家通过使用地图作为模板切割样本，以便进行组织学分析，并将每个切片的位置和取向与其在乳房中的解剖位置相关联，从而通过以下方式指导精确和解剖学上准确的再切除 外科医生如果需要的话。

    Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia
    16.
    发明授权
    Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia 有权
    组合电离辐射和免疫调节剂递送装置和抑制增生的方法

    公开(公告)号：US07041046B2

    公开(公告)日：2006-05-09

    申请号：US09850728

    申请日：2001-05-07

    Applicant: Michael R. Forman

    Inventor： Michael R. Forman

    IPC: A61N5/00

    CPC classification number: A61K51/1282 ,  A61M25/002 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1097 ,  A61N5/1001 ,  A61N2005/1003 ,  A61N2005/1004

    Abstract: The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled immunomodulator delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and immunomodulator delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an immunomodulator to the body lumen.

    Abstract translation: 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供与电离辐射组合的受控免疫调节剂递送至患者脉管系统内的选定位置，以减少和/或抑制再狭窄和增生率与增加的功效。 在一个实施方案中，用于抑制增生的组合辐射和免疫调节剂递送导管包括具有近端和远端的导管主体，可耦合到导管主体的用于将辐射剂量施加到体腔的电离辐射源，以及多孔材料， 基质，膜，屏障，涂层，输液腔，支架，移植物或储存器，用于将免疫调节剂释放到体腔。

    Radiation for inhibiting hyperplasia after intravascular intervention
    17.
    发明授权
    Radiation for inhibiting hyperplasia after intravascular intervention 有权
    用于抑制血管内干预后增生的辐射

    公开(公告)号：US06390967B1

    公开(公告)日：2002-05-21

    申请号：US09661438

    申请日：2000-09-14

    Applicant: Michael R. Forman ,  Paul A. Lovoi ,  Tom W. Rusch

    Inventor： Michael R. Forman ,  Paul A. Lovoi ,  Tom W. Rusch

    IPC: A61N500

    CPC classification number: A61N5/1002 ,  A61N2005/1003 ,  A61N2005/1021

    Abstract: Apparatus and methods are provided for applying a radially uniform radiation dose to an intravascular treatment region to inhibit hyperplanes, and specifically to reduce “candy-wrapper” ends, following intravascular intervention. An embodiment of the apparatus comprises a catheter body having a proximal end and a distal end, a pair of axially spaced apart radiation shields on the catheter body, and a radiation source. The radiation source applies a radiation dose which is substantially uniform in a radial direction over an entire distance between the axially spaced apart shields.

    Abstract translation: 提供了设备和方法，用于将径向均匀的辐射剂量施加到血管内治疗区域以抑制超平面，并且具体地减少血管内干预后的“糖果包裹物”端。 该装置的实施例包括具有近端和远端的导管主体，导管主体上的一对轴向隔开的辐射屏蔽和辐射源。 辐射源施加辐射剂量，其在轴向间隔开的屏蔽之间的整个距离处在径向方向上基本均匀。

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