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公开(公告)号：US10921579B2
公开(公告)日：2021-02-16
申请号：US15539488
申请日：2015-12-23
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA , BANK OF CANADA
Inventor： Daniel Brassard , Lidija Malic , Keith J. Morton , Teodor Veres , Charles D. MacPherson , Theodoros Garanzotis
IPC: G02B26/00 , G02B26/02 , G02B1/00 , B42D25/405 , B42D25/29 , B82Y20/00 , B82B1/00 , B42D25/36 , G02F1/01 , G06Q30/00 , G02F1/17
Abstract: A security device that elicits at least one dynamic response upon acceleration, or upon change of orientation with respect to gravity, wherein the dynamic response continues after cessation of the acceleration or the change of orientation. In addition, the dynamic response can be optical, such that it is visually observable by an unaided human eye. Alternatively, the response can be machine readable. In some cases, the dynamic response has duration of from about 0.01 s to about 100 s, or from about Is to about 10 s.
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公开(公告)号：US10569225B2
公开(公告)日：2020-02-25
申请号：US14779446
申请日：2014-03-27
Applicant: National Research Council of Canada , The Royal Institution for the Advancement of Learning/McGill University
Inventor： Kebin Li , Teodor Veres , Tohid Fatanat Didar , Maryam Tabrizian
Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
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13.发明授权Centrifugal microfluidic mixing apparatus with deflection element, and method of mixing 有权具有偏转元件的离心微流体混合装置及其混合方法公开(公告)号：US09555382B2
公开(公告)日：2017-01-31
申请号：US13261941
申请日：2013-02-18
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
Inventor： Liviu Clime , Teodor Veres
CPC classification number: B01F13/0059 , B01F5/0606 , B01F13/0069 , B01F15/0233 , B81B7/00
Abstract: A centrifugal microfluidic device having a microfluidic mixing element with a microfluidic mixing chamber in which at least two flows emerging from channels into the chamber at separate places are redirected to land at substantially the same place on a mixing surface provides efficient mixing of two or more fluids in the chamber.
Abstract translation: 一种具有微流体混合元件的离心微流体装置，其具有微流体混合室，其中至少两个在分开的位置处从通道流入室中的流被重定向到在混合表面上的基本相同的位置上的平台提供了两种或多种流体的有效混合 在房间里。
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公开(公告)号：US20160250633A1
公开(公告)日：2016-09-01
申请号：US14989320
申请日：2016-01-06
Applicant: National Research Council of Canada
Inventor： Emmanuel Roy , Teodor Veres
CPC classification number: B01L3/502707 , B01L3/5027 , B01L2200/12 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B29C41/045 , B29C59/02 , B29C65/02 , B29C71/02 , B29K2019/00 , B29K2995/0026 , B29K2995/0046 , B29K2995/0056 , B29K2995/007 , B29L2009/00 , B32B3/30 , B32B7/02 , B32B25/04 , B32B25/14 , B32B27/28 , B32B27/302 , B32B2270/00 , B32B2274/00 , B32B2307/306 , B32B2307/536 , B32B2307/546 , C08J5/18 , C08J2309/06 , C08J2323/04 , C08J2323/20 , C08J2325/08 , C08J2353/00 , Y10T428/24802
Abstract: A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.
Abstract translation: 由至少60重量％ ％的热塑性弹性体树脂和至少0-50℃固体的添加剂，其具有小于约50的肖氏A硬度带有图案化表面，该图案包括至少一个具有交联的微流体通道， 小于100微米的截面尺寸是用于形成微流体装置的衬底。 这种组合物的主要优点是：其以密封方式粘合到许多不同组合物的光滑表面，其易于制造和微结构图案化以及其对液体的一般不渗透性的能力。
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15.发明授权公开(公告)号：US11278890B2
公开(公告)日：2022-03-22
申请号：US17265162
申请日：2019-08-06
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
Inventor： Ryan Denomme , Lidija Malic , Daniel Brassard , Keith Morton , Teodor Veres
IPC: B01L3/00 , G01N21/552 , G01N33/543
Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.
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Patent Agency Ranking
公开(公告)号：US11071985B2
公开(公告)日：2021-07-27
申请号：US15313961
申请日：2015-05-26
Applicant: National Research Council of Canada
Inventor： Liviu Clime , Teodor Veres , Keith Morton
Abstract: A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part (18) that couples to, or defines, a blade (10) of a centrifuge at a radial distance from a centrifuge axis (12); a chip part (20) that holds the chip at an orientation having a normal not perpendicular to the axis; a one degree of freedom (DoF) joint (16) between the blade part and the chip part; and a force applicator (28) which bears on the chip part at a fixed set of one or more points, which do not surround, and are not surrounded by, the joint.
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公开(公告)号：US20210173197A1
公开(公告)日：2021-06-10
申请号：US17123233
申请日：2020-12-16
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA , BANK OF CANADA
Inventor： Daniel BRASSARD , Lidija Malic , Keith J. Morton , Teodor Veres , Charles D. Macpherson , Theodoros Garanzotis
IPC: G02B26/02 , B42D25/36 , B82B1/00 , B82Y20/00 , B42D25/405 , G02B1/00 , G02F1/01 , G06Q30/00 , B42D25/29 , G02F1/17
Abstract: A security device that exhibits at least one dynamic response upon change of orientation of the security device with respect to gravity, wherein the security device includes a hollow capsule completely filled with a liquid and one or more microscopic elements. In addition, the dynamic response continues after cessation of the change of orientation with respect to gravity. The dynamic response includes a transition of the one or more microscopic elements from substantial mechanical equilibrium to non-equilibrium upon action of the change of orientation with respect to gravity and back to substantial mechanical equilibrium after cessation of the change of orientation with respect to gravity. During the dynamic response, the one or more microscopic elements undergo at least one of a rotational motion and a translational motion relative to the liquid.
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公开(公告)号：US20200223999A1
公开(公告)日：2020-07-16
申请号：US16651018
申请日：2018-09-25
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
Inventor： Lidija Malic , Xuefeng Zhang , Keith Morton , Teodor Veres
Abstract: The present application relates to polymer film-metal composites, to methods of preparing polymer film-metal composites and to uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.
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19.发明申请公开(公告)号：US20200223948A1
公开(公告)日：2020-07-16
申请号：US16651067
申请日：2018-09-25
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
Inventor： Lidija Malic , Xuefeng Zhang , Keith Morton , Teodor Veres
Abstract: The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.
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公开(公告)号：US10702868B2
公开(公告)日：2020-07-07
申请号：US15124236
申请日：2015-03-04
Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
Inventor： Teodor Veres , Daniel Brassard , Liviu Clime , Francois Normandin
IPC: B01L3/00 , G01N35/00 , B01F9/00 , B01F13/00 , B01F13/02 , B01F15/00 , B01F15/02 , G05D7/06 , G01N35/04 , B01L7/00
Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.
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