公开(公告)号：US20210170007A1

公开(公告)日：2021-06-10

申请号：US17015177

申请日：2020-09-09

Applicant: President and Fellows of Harvard College

Inventor： Michael Super ,  Edward J. Doherty ,  Mark Joseph Cartwright ,  Des White ,  Alexander Stafford ,  Omar Abdel-Rahman Ali ,  Amanda Graveline ,  Donald E. Ingber ,  David J. Mooney ,  Benjamin Seiler

IPC: A61K39/108 ,  A61K39/02

Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

公开(公告)号：US10813988B2

公开(公告)日：2020-10-27

申请号：US15434781

申请日：2017-02-16

Applicant: President and Fellows of Harvard College

Inventor： Michael Super ,  Edward J. Doherty ,  Mark Cartwright ,  Des White ,  Alexander G. Stafford ,  Omar Abdel-Rahman Ali ,  Amanda Graveline ,  Donald E. Ingber ,  David J. Mooney ,  Benjamin Seiler

IPC: A61K39/108 ,  A61K39/02 ,  A61K39/00

Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

公开(公告)号：US10245355B2

公开(公告)日：2019-04-02

申请号：US14904399

申请日：2014-07-10

Applicant: President and Fellows of Harvard College

Inventor： Donald Ingber ,  Daniel C. Leslie ,  Michael Super ,  Alexander L. Watters ,  Anna Waterhouse

IPC: B05D5/08 ,  B05D5/12 ,  A61L27/34 ,  A61L29/14 ,  A61L31/10 ,  A61L33/00 ,  A61L31/08 ,  A61L29/08 ,  C09D5/16 ,  A61L31/14

Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

公开(公告)号：US09988617B2

公开(公告)日：2018-06-05

申请号：US14892252

申请日：2014-05-21

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Michael Super ,  Alexander L. Watters ,  Philip T. Snell ,  Donald E. Ingber

IPC: C12N9/96 ,  C12N9/26 ,  A61K38/00 ,  C07K14/805

CPC classification number: C12N9/2474 ,  A61K38/00 ,  C07K14/805 ,  C12N9/96 ,  C12Y302/01035

Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.

公开(公告)号：US09791440B2

公开(公告)日：2017-10-17

申请号：US14904583

申请日：2014-07-15

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Mark J. Cartwright ,  Nazita Gamini ,  Donald E. Ingber ,  Martin Rottman ,  Michael Super ,  Julie A. Tomolonis ,  Karen A. Sinclair

IPC: A61K39/02 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/569 ,  C12Q1/18

CPC classification number: G01N33/56911 ,  C12Q1/18 ,  G01N33/5695 ,  G01N33/56961 ,  G01N2333/4724 ,  G01N2400/00 ,  G01N2800/26 ,  G01N2800/52

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

公开(公告)号：US20170246281A1

公开(公告)日：2017-08-31

申请号：US15434781

申请日：2017-02-16

Applicant: President and Fellows of Harvard College

Inventor： Michael Super ,  Edward J. Doherty ,  Mark Cartwright ,  Des White ,  Alexander G. Stafford ,  Omar Abdel-Rahman Ali ,  Amanda Graveline ,  Donald E. Ingber ,  David J. Mooney ,  Benjamin Seiler

IPC: A61K39/108 ,  A61K39/02

Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

公开(公告)号：US20150005188A1

公开(公告)日：2015-01-01

申请号：US14366486

申请日：2012-12-21

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Daniel Levner ,  Jehyuk Lee ,  George M. Church ,  Michael Super

IPC: C12Q1/68

CPC classification number: C12Q1/6837 ,  C12Q1/6804 ,  C12Q1/6816 ,  G01N33/53 ,  G01N2458/10 ,  C12Q2535/122 ,  C12Q2537/143 ,  C12Q2563/107 ,  C12Q2563/179 ,  C12Q2565/514

Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.

Abstract translation: 本文提供的发明涉及包含用于样品中分析物的检测，鉴定和/或定量的检测试剂的检测试剂，组合物，方法和试剂盒。 本文所述的这种检测试剂和方法允许以与常规方法相同的方法复用多个标记的物质，其中多路复用受可用和实际可用颜色的数量限制。

公开(公告)号：US20140342954A1

公开(公告)日：2014-11-20

申请号：US14371728

申请日：2013-01-10

Applicant: President and Fellows of Harvard College

Inventor： Donald Ingber ,  Daniel C. Leslie ,  Alexander L. Watters ,  Michael Super ,  Joanna Aizenberg ,  Michael Aizenberg ,  Philseok Kim ,  Anna Waterhouse

IPC: A61L33/04

CPC classification number: A61L33/04 ,  A61L29/06 ,  A61L29/08 ,  A61L29/14 ,  A61L33/0041 ,  A61L33/0094 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  B05D1/60 ,  B05D3/107 ,  B05D5/086 ,  B05D7/02 ,  C09D5/1656 ,  C09D5/1693 ,  C08L83/04

Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has a head group that is covalently linked to, or adsorbed onto, the surface and a functional group. The functional group of the treated surface has an affinity for a lubricating layer, which is applied to the treated surface. The anchoring layer and replenishable lubricating layer are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

Abstract translation: 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有共价连接或吸附在表面上的头基和官能团。 经处理的表面的官能团对施加到被处理表面的润滑层具有亲和性。 锚定层和可补充润滑层通过非共价吸引力保持在一起。 这些层一起形成一个超疏水滑表面，排斥某些不混溶液体，并防止其中所含组分的吸附，凝结和表面结垢。

公开(公告)号：US20250059590A1

公开(公告)日：2025-02-20

申请号：US18936042

申请日：2024-11-04

Applicant: President and Fellows of Harvard College

Inventor： George M. Church ,  Jehyuk Lee ,  Daniel Levner ,  Michael Super

IPC: C12Q1/6806 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53

Abstract: Methods of analyzing nucleic acids of a cell are provided.

公开(公告)号：US11939608B2

公开(公告)日：2024-03-26

申请号：US17698576

申请日：2022-03-18

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Michael Super ,  Alexander L. Watters ,  Philip T. Snell ,  Donald E. Ingber

IPC: C12N9/26 ,  A61K38/00 ,  C07K14/805 ,  C12N9/96

CPC classification number: C12N9/2474 ,  A61K38/00 ,  C07K14/805 ,  C12N9/96 ,  C12Y302/01035

Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.