公开(公告)号：US20120223217A1

公开(公告)日：2012-09-06

申请号：US13411302

申请日：2012-03-02

申请人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang

发明人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang

IPC分类号： G01J1/02

CPC分类号： B01L3/508 ,  B01L3/502792 ,  B01L2300/0654 ,  C12M23/10 ,  G01N21/03 ,  G01N21/25 ,  G01N21/272 ,  G01N2201/10 ,  G02B21/0008 ,  G02B21/06 ,  G02B21/367 ,  G03H1/0443 ,  G03H1/0465 ,  G03H2001/0447 ,  G03H2222/34 ,  G03H2240/56

摘要： An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.

摘要翻译： 一种电子培养皿，包括具有样本表面的透明层和被配置为对位于样本表面上的样本的亚像素偏移的投影图像的序列进行采样的光检测器。 子像素偏移与由照明源提供的多个照明角度的光相关联的投影图像。

公开(公告)号：US20120070817A1

公开(公告)日：2012-03-22

申请号：US13237796

申请日：2011-09-20

申请人： Ying Min Wang ,  Changhuei Yang

发明人： Ying Min Wang ,  Changhuei Yang

IPC分类号： C12Q3/00 ,  C12M1/42

CPC分类号： A61B5/0059 ,  G01N21/1717 ,  G01N21/47 ,  G01N21/49 ,  G01N21/65 ,  G01N2021/1727 ,  G01N2021/4709

摘要： A method, apparatus, and article of manufacture for irradiating one or more targets within a sample with electromagnetic (EM) radiation. One or more targets within the sample are controllably defined with an acoustic field. The sample is irradiated with input EM radiation having an input wavefront. An amount of frequency shifted EM radiation is detected, wherein at least some of the input EM radiation that passes through the acoustic field at the targets is shifted in frequency to form the frequency shifted EM radiation. The input wavefront is modified, using feedback comprising the amount of the frequency shifted EM radiation that is detected, into a modified wavefront. The sample is irradiated using the input EM radiation comprising the modified wavefront, and the process is repeated as desired.

摘要翻译： 一种用于用电磁（EM）辐射照射样品内的一个或多个靶的方法，装置和制品。 样本内的一个或多个目标是可控地用声场定义的。 用具有输入波前的输入EM辐射照射样品。 检测到一定量的频移EM辐射，其中穿过目标处的声场的输入EM辐射中的至少一些频率偏移以形成频移的EM辐射。 输入波前被修改，使用包括被检测的频移EM辐射的量的反馈到修改的波前。 使用包括经修改的波前的输入EM辐射照射样品，并根据需要重复该过程。

公开(公告)号：US20120026509A1

公开(公告)日：2012-02-02

申请号：US13157245

申请日：2011-06-09

申请人： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis

发明人： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis

IPC分类号： G01B9/02 ,  G02B21/10 ,  G02B5/18

CPC分类号： G02B21/0056 ,  G01N21/553 ,  G02B21/18 ,  G02B21/361

摘要： A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

摘要翻译： 差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。 此外，表面波辅助光流体显微镜和方法利用照明源，具有至少一个孔的层作为表面的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。 该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。

公开(公告)号：US08039776B2

公开(公告)日：2011-10-18

申请号：US12435165

申请日：2009-05-04

申请人： Xiquan Cui ,  Changhuei Yang ,  Guillermo J. Tearney

发明人： Xiquan Cui ,  Changhuei Yang ,  Guillermo J. Tearney

IPC分类号： G01J1/20

CPC分类号： G02B21/0092 ,  G01J9/02 ,  G02B21/14 ,  H01L27/14643

摘要： A wavefront microscope or camera utilizes a wavefront sensor to measure the local intensity and phase gradient of the wavefront and output image maps based on the intensity and phase gradient. A wavefront sensor provides a metal film having patterned structured two dimensional (2D) apertures that convert a phase gradient of a wavefront into a measurable form onto a photodetector array. A computer is used to analyze the data by separating signals projected and recorded on the array from the different apertures, predict a center of each projection, and sum signals for each projection to display the intensity while determining a center position change/offset from the predicted center to display the phase gradient of the wavefront.

摘要翻译： 波前显微镜或相机利用波前传感器来测量波前的局部强度和相位梯度，并根据强度和相位梯度输出图像图。 波前传感器提供具有图案化结构化二维（2D）孔径的金属膜，其将波前的相位梯度转换成可测量的形式到光电检测器阵列上。 计算机用于通过将从阵列中投影和记录的信号与不同的孔分开来预测每个投影的中心，并且每个投影的和信号显示强度同时确定从预测的中心位置改变/偏移 中心显示波前的相位梯度。

公开(公告)号：US20100195873A1

公开(公告)日：2010-08-05

申请号：US12690952

申请日：2010-01-21

申请人： Xiquan Cui ,  Changhuei Yang

发明人： Xiquan Cui ,  Changhuei Yang

IPC分类号： G06K9/62

CPC分类号： G01N21/45 ,  G01B11/2441 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/18 ,  G02B21/367

摘要： Embodiments of the present invention relate to a method for computing depth sectioning of an object using a quantitative differential interference contrast device having a wavefront sensor with one or more structured apertures, a light detector and a transparent layer between the structured apertures and the light detector. The method comprises receiving light, by the light detector, through the one or more structured apertures. The method also measures the amplitude of an image wavefront, and measures the phase gradient in two orthogonal directions of the image wavefront based on the light. The method can then reconstruct the image wavefront using the amplitude and phase gradient. The method can then propagate the reconstructed wavefront to a first plane intersecting an object at a first depth. In one embodiment, the method propagates the reconstructed wavefront to additional planes and generates a three-dimensional image based on the propagated wavefronts.

摘要翻译： 本发明的实施例涉及一种使用具有一个或多个结构化孔径的波前传感器，光检测器和结构化孔径与光检测器之间的透明层的定量差分干涉对比装置来计算物体的深度截面的方法。 该方法包括通过光检测器接收通过一个或多个结构化孔的光。 该方法还测量图像波前的幅度，并且基于光测量图像波前的两个正交方向上的相位梯度。 该方法可以使用幅度和相位梯度来重构图像波前。 该方法然后可以将重建的波前传播到在第一深度与物体相交的第一平面。 在一个实施例中，该方法将重建的波前传播到附加平面，并且基于传播的波前产生三维图像。

公开(公告)号：US07751048B2

公开(公告)日：2010-07-06

申请号：US11686095

申请日：2007-03-14

申请人： Changhuei Yang ,  Demetri Psaltis

发明人： Changhuei Yang ,  Demetri Psaltis

IPC分类号： G01N21/00

CPC分类号： G01N21/6458 ,  B82Y30/00

摘要： Optofluidic microscope devices and methods of using optofluidic microscope devices, where each optofluidic device comprises a body with a fluid channel having a surface, light transmissive regions in the body wherein the light transmissive regions have different dimensions, an illumination source adapted to provide illumination through the light transmissive regions, and an optical detector adapted to receive light from the illumination source through the light transmissive regions. The light transmissive regions and optical detector can be used to image an object flowing through the fluid channel.

摘要翻译： 光学显微镜装置和使用光流体显微镜装置的方法，其中每个光流体装置包括具有表面的流体通道的主体，身体中的透光区域，其中透光区域具有不同的尺寸，照明源适于通过 光透射区域，以及适于通过透光区域接收来自照明源的光的光学检测器。 透光区域和光学检测器可用于对流过流体通道的物体进行成像。

公开(公告)号：US20090276188A1

公开(公告)日：2009-11-05

申请号：US12435165

申请日：2009-05-04

申请人： Xiquan Cui ,  Changhuei Yang

发明人： Xiquan Cui ,  Changhuei Yang

IPC分类号： G01B9/02 ,  H01L27/142 ,  G06F15/00

CPC分类号： G02B21/0092 ,  G01J9/02 ,  G02B21/14 ,  H01L27/14643

摘要： A wavefront microscope or camera utilizes a wavefront sensor to measure the local intensity and phase gradient of the wavefront and output image maps based on the intensity and phase gradient. A wavefront sensor provides a metal film having patterned structured two dimensional (2D) apertures that convert a phase gradient of a wavefront into a measurable form onto a photodetector array. A computer is used to analyze the data by separating signals projected and recorded on the array from the different apertures, predict a center of each projection, and sum signals for each projection to display the intensity while determining a center position change/offset from the predicted center to display the phase gradient of the wavefront.

摘要翻译： 波前显微镜或相机利用波前传感器来测量波前的局部强度和相位梯度，并根据强度和相位梯度输出图像图。 波前传感器提供具有图案化结构化二维（2D）孔径的金属膜，其将波前的相位梯度转换成可测量的形式到光电检测器阵列上。 计算机用于通过将从阵列中投影和记录的信号与不同的孔分开来预测每个投影的中心，并且每个投影的和信号显示强度同时确定从预测的中心位置改变/偏移 中心显示波前的相位梯度。

公开(公告)号：US07364543B2

公开(公告)日：2008-04-29

申请号：US11535427

申请日：2006-09-26

申请人： Changhuei Yang ,  Jigang Wu

发明人： Changhuei Yang ,  Jigang Wu

IPC分类号： A61B1/07 ,  G01J3/45

CPC分类号： A61B5/6852 ,  A61B1/00096 ,  A61B1/00172 ,  A61B5/0062 ,  A61B5/0066

摘要： Probes, and systems and methods for optically scanning a conical volume in front of a probe, for use with an imaging modality, such as Optical Coherence Tomography (OCT). A probe includes an optical fiber having a proximal end and a distal end and defining an axis, with the proximal end of the optical fiber being proximate a light source, and the distal end having a first angled surface. A refractive lens element is positioned proximate the distal end of the optical fiber. The lens element and the fiber end are both configured to separately rotate about the axis so as to image a conical scan volume when light is provided by the source. Reflected light from a sample under investigation is collected by the fiber and analyzed by an imaging system. Such probes may be very compact, e.g., having a diameter 1 mm or less, and are advantageous for use in minimally invasive surgical procedures. A fluid medium can be introduced between two lens elements at the distal end of the probe to switch a mode from side viewing to forward viewing.

摘要翻译： 探针，以及用于光学扫描探针前面的锥形体积的系统和方法，用于成像模态，例如光学相干断层扫描（OCT）。 探针包括具有近端和远端并限定轴线的光纤，光纤的近端靠近光源，并且远端具有第一倾斜表面。 折射透镜元件靠近光纤的远端定位。 透镜元件和光纤端都被构造为围绕轴线分开旋转，以便在由光源提供光时对圆锥扫描体积进行成像。 被研究样品的反射光由纤维收集并通过成像系统进行分析。 这种探针可以非常紧凑，例如具有1mm或更小的直径，并且有利于用于微创外科手术。 可以在探针的远端的两个透镜元件之间引入流体介质以将模式从侧视图切换到向前观察。

公开(公告)号：US20080002209A1

公开(公告)日：2008-01-03

申请号：US11770553

申请日：2007-06-28

申请人： Zahid Yaqoob ,  Jigang Wu ,  Marinko Venci Sarunic ,  Changhuei Yang

发明人： Zahid Yaqoob ,  Jigang Wu ,  Marinko Venci Sarunic ,  Changhuei Yang

IPC分类号： G01B9/02

CPC分类号： G01B9/0201 ,  G01B9/02004 ,  G01B9/02081 ,  G01B9/0209 ,  G01B2290/30 ,  G01B2290/45

摘要： A method and device realize shallow gratings-based planar beam splitter/combiner. Non-trivial phase shifts between different ports of resulting interferometers are used to acquire full-field phase measurements. The non-trivial phase shifts between different ports of the planar beam splitter/combiner can be adjusted by simply shearing one grating with respect to the second grating. The two shallow diffraction gratings are harmonically-related and can be recorded on a single substrate for compact interferometric based schemes. During the recording process, the two gratings are aligned such that the grating planes and the grating vectors are parallel to that of each other. The relative phase of the recording beams controls the shearing between the recorded harmonically-related shallow phase gratings. The relative shearing of the two gratings defines the non-trivial phase shift between different ports of the compact planar beam splitter/combiner.

摘要翻译： 一种方法和装置实现了基于光栅的平面光束分离器/组合器。 所得干涉仪的不同端口之间的非平凡相移用于获取全场相位测量。 平面分束器/组合器的不同端口之间的非平凡相移可以通过相对于第二光栅简单地剪切一个光栅来调节。 两个浅衍射光栅是谐波相关的，并且可以记录在单个基板上，用于紧凑的基于干涉的方案。 在记录过程中，两个光栅对齐，使得光栅平面和光栅矢量彼此平行。 记录光束的相对相位控制记录的谐波相关浅相位光栅之间的剪切。 两个光栅的相对剪切定义了紧凑型平面分束器/组合器的不同端口之间的非平凡相移。

公开(公告)号：US20070207061A1

公开(公告)日：2007-09-06

申请号：US11686095

申请日：2007-03-14

申请人： Changhuei Yang ,  Demetri Psaltis

发明人： Changhuei Yang ,  Demetri Psaltis

IPC分类号： G01N21/00 ,  B32B27/04

CPC分类号： G01N21/6458 ,  B82Y30/00

摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light transmissive regions of different sizes may be used to image the object.

摘要翻译： 公开了一种光流体显微镜装置。 该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。 可以使用不同尺寸的透光区域对物体进行成像。