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    Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
    3.
    发明授权
    Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors 有权
    基于波前传感器的定量微分干涉对比（DIC）显微镜和摄影

    公开(公告)号：US08039776B2

    公开(公告)日：2011-10-18

    申请号：US12435165

    申请日：2009-05-04

    申请人： Xiquan Cui ,  Changhuei Yang ,  Guillermo J. Tearney

    发明人： Xiquan Cui ,  Changhuei Yang ,  Guillermo J. Tearney

    IPC分类号： G01J1/20

    CPC分类号： G02B21/0092 ,  G01J9/02 ,  G02B21/14 ,  H01L27/14643

    摘要： A wavefront microscope or camera utilizes a wavefront sensor to measure the local intensity and phase gradient of the wavefront and output image maps based on the intensity and phase gradient. A wavefront sensor provides a metal film having patterned structured two dimensional (2D) apertures that convert a phase gradient of a wavefront into a measurable form onto a photodetector array. A computer is used to analyze the data by separating signals projected and recorded on the array from the different apertures, predict a center of each projection, and sum signals for each projection to display the intensity while determining a center position change/offset from the predicted center to display the phase gradient of the wavefront.

    摘要翻译： 波前显微镜或相机利用波前传感器来测量波前的局部强度和相位梯度，并根据强度和相位梯度输出图像图。 波前传感器提供具有图案化结构化二维（2D）孔径的金属膜，其将波前的相位梯度转换成可测量的形式到光电检测器阵列上。 计算机用于通过将从阵列中投影和记录的信号与不同的孔分开来预测每个投影的中心，并且每个投影的和信号显示强度同时确定从预测的中心位置改变/偏移 中心显示波前的相位梯度。

    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S)
    6.
    发明申请
    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
    用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分

    公开(公告)号：US20130066215A1

    公开(公告)日：2013-03-14

    申请号：US13614459

    申请日：2012-09-13

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    IPC分类号： A61B1/07

    CPC分类号： A61B1/07 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B18/22 ,  A61B2017/00061

    摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

    摘要翻译： 可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。 例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。 第一和第二范围可以在该部分上部分重叠。 此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。

    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION
    10.
    发明申请
    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 有权
    系统，方法和计算机可访问介质，提供特定解决方案中至少一个解剖结构的微观图像

    公开(公告)号：US20110261366A1

    公开(公告)日：2011-10-27

    申请号：US13042230

    申请日：2011-03-07

    申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Joseph A. Gardecki ,  Linbo Liu

    发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Joseph A. Gardecki ,  Linbo Liu

    IPC分类号： G01B9/02

    CPC分类号： A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

    摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

    摘要翻译： 可以提供可以生成与样品的至少一部分相关联的数据的系统和方法的示例性实施例。 例如，可以通过至少一个光学布置将至少一个第一辐射转发到该部分。 可以从基于第一辐射的部分接收至少一个第二辐射。 基于光学布置和第一辐射和/或第二辐射之间的相互作用，光学装置可以具有第一传递函数。 此外，可以通过这种光学装置（或通过另一种光学装置）将至少一个第三辐射转发到该部分，并且从基于第三辐射的部分接收至少一个第四辐射。 基于光学布置（或另一个光学布置）与第三辐射和/或第四辐射之间的相互作用，光学布置（或另一个光学布置）可以具有第二传递函数。 第一传递函数可以至少部分地不同于第二传递函数。 可以基于第二和第四辐射来生成数据。