摘要:
A measurement device (100) comprising an accommodation chamber (102) adapted for accommodating a replaceable measurement member (104), a movable closure mechanism (106) adapted to be moved to selectively expose or cover the accommodation chamber (102), and a data mechanism (600) adapted for at least one of reading data from and writing data on a replaceable measurement member (104), when the replaceable measurement member (104) is accommodated in the accommodation chamber (102), upon moving the movable closure mechanism (106).
摘要:
A microfluidic arrangement (1) for the optical detection of fluids is provided, comprising a microfluidic device (2) having at least one first channel (3) with an opening (4) which is in fluid communication with an optical detection unit (6) of an optical device (5); the microfluidic device (2) being operatively detachably coupled with the optical device (5) whereby an extension of the part (7,7′) of relevance of the optical detection path (17) is provided. A method for detecting fluids using the arrangement of the present invention is provided.
摘要:
An insert element for a gel electrophoresis device, the insert element comprising a carrier element comprising one or more gel strip receptions, wherein each of the one or more gel strip receptions is adapted to receive a gel strip, and wherein each of the one or more gel strip receptions is adapted to receive a compartment frame to be located close to the gel strip.
摘要:
What is described in this case is a laboratory microchip having microspray means whose direction of spray can be altered. The microchip has a substrate 40 which has a channel structure provided on one side 41 thereof. On the other side (in the region of an edge of the substrate in the present case), there is a microspray tip 42. Substrate 40 is designed to be deformable particularly in a region 43, in which case the deformability may be achieved either by thinning the substrate material locally in this region 43 or by means of a linear perforation extending approximately perpendicularly to the plane of the paper. Alternatively, the deformability may be obtained by selecting a suitable material for the entire substrate. A microchip which has been bent in the manner indicated is shown in the bottom part of FIG. 3. The bending of the substrate which is shown has turned the direction of spray 44 of microspray tip 42 through 90°. The bending of the substrate may be permanent or reversible in this case.
摘要:
A laboratory microchip includes a carrier with a micro spray tip projecting vertically out of a plane of the carrier. The carrier and spray tip are designed as a monolithic or single unit. The spray tip includes a passage channel which conveys the substances to be sprayed from a channel to a spray tip aperture. The channel is a part of a channel structure which is enclosed to the outside by a cover plate. The spray tip includes, on the sides of the spray aperture, an area which tapers conically inwards. Connected to this tapered area is a constant cross-section drill hole forming an annular internal step formation at the transition between the two areas. The outer diameter of the conically tapering tip is locally reduced in proximity to the aperture to provide a finer tip to the spray tip. The finer tip increases the electrical fields occurring at the tip, to further increase the forces which act on the substances and for dispersion spraying.
摘要:
An apparatus for performing capillary electrophoresis comprises a housing (37) to which a sealing and electrode arrangement (36) is fastened and a removable cassette (22) which accommodates a capillary (1) in which electrophoretic separation of a sample takes place when an electric field is applied. When performing an electrophoretic separation, the end of the capillary (1) and a tube-shaped electrode (39) surrounding the capillary (1) dip into a liquid vial containing electrolyte or sample liquid. Liquid is injected into the capillary (1) by applying pressure on the liquid in the vial. An elastomeric seal (40) around the capillary (1) is provided to prevent escaping of the pressure during injection. The end of the capillary (1) depending from the cassette (20) is introduced through a funnel (41) and a central bore in the seal (40). When the cassette (20) is pressed downwards onto the funnel (41), the elastomeric seal (40) is squeezed so that the capillary (1) is sealed off. Since the seal ( 40) is arranged in the housing (37), no sealing is required in the cassette, resulting in a simpler construction of the cassette and facilitating replacement of the capillary in the cassette. (FIG. 4)
摘要:
An electrode arrangement for a gel electrophoresis device, the electrode arrangement comprising a first electrode member adapted to provide an electrical contact with one or more gel strips, wherein the first electrode member comprises a first locking element to lock the first electrode member to the gel electrophoresis device.
摘要:
A supply arrangement includes a supply reservoir element and a microfluidic device, wherein the supply reservoir element has a first reservoir unit having a prefilled liquid reagent therein, and the microfluidic device has a reception device adapted for receiving the liquid reagent from the first reservoir unit. The supply reservoir element is coupled to the microfluidic device. One of the supply reservoir element and the microfluidic device includes a puncturing element in order to cause fluid flow of the liquid reagent from the first reservoir unit to the reception device when the puncturing element is operated. The supply reservoir element has a basal plane, and the first reservoir unit has a first blister element arranged on the basal plane.
摘要:
Described is a novel marker protein associated with epithelial tumors, e.g., ovarian, mammary, stomach, kidney, thyroid and lung carcinomas, Dropl, a dystrophin-related protein as well as a nucleic acid molecule encoding Dropl. Furthermore, various diagnostic and therapeutic uses based on the finding that the expression of Dropl is downregulated in epithelial tumors are described.
摘要:
A laboratory microchip providing a microspray has a substrate having a channel structure on one side thereof. A microspray tip is on the other side of the substrate close to an edge of the substrate. The substrate is deformable in a particular region. Deformation results from thinning the substrate locally in the region or by providing a linear perforation that extends approximately perpendicular to the plane of the substrate. Alternatively, deformation can be obtained by selecting a suitable material for the entire substrate. Substrate deformation can be permanent or reversible.