公开(公告)号：US08986524B2

公开(公告)日：2015-03-24

申请号：US13359766

申请日：2012-01-27

申请人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Philip S. Waggoner

发明人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Philip S. Waggoner

IPC分类号： G01N27/447 ,  B82Y15/00 ,  G01N33/487 ,  C12Q1/68

CPC分类号： G01N33/48721 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N27/44791 ,  Y10S977/924 ,  C12Q2563/157

摘要： A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.

摘要翻译： 纳米器件包括填充有导电流体的储存器和分离储存器的膜。 通过具有由绝缘层分隔的电极层的膜形成纳米孔。 某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。 第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。 当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为要测量的第一和第二瞬态键作为用于区分基底的当前签名行进。 运动控制瞬态键比第一和第二瞬态键强。

公开(公告)号：US20110312176A1

公开(公告)日：2011-12-22

申请号：US12820543

申请日：2010-06-22

申请人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

发明人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

IPC分类号： H01L21/283 ,  H01L21/441 ,  C23C28/00 ,  C30B23/02 ,  C23C14/34 ,  B05D3/14 ,  B05D5/12 ,  B05D3/06

CPC分类号： B82Y10/00 ,  H01L21/76834 ,  H01L29/0665 ,  H01L51/0093 ,  H01L51/0504 ,  H01L51/102

摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.

摘要翻译： 因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。 提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。 氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。 根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

公开(公告)号：US08354336B2

公开(公告)日：2013-01-15

申请号：US12820543

申请日：2010-06-22

申请人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

发明人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

IPC分类号： H01L21/28 ,  H01L21/3205

CPC分类号： B82Y10/00 ,  H01L21/76834 ,  H01L29/0665 ,  H01L51/0093 ,  H01L51/0504 ,  H01L51/102

摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.

摘要翻译： 因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。 提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。 氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。 根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

公开(公告)号：US20110308969A1

公开(公告)日：2011-12-22

申请号：US12820574

申请日：2010-06-22

申请人： Ali Afzali-Azdakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

发明人： Ali Afzali-Azdakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

IPC分类号： G01N17/04

CPC分类号： G01N17/04

摘要： The present invention provides a method of reducing corrosion and water decomposition on a surface of an electrode having a titanium nitride conductive layer disposed on a substrate and estimating extent of reduction thereof. The electrode is immersed into a solution containing a hydroxyl-functional compound. Thereafter, a voltage is applied to the titanium nitride conductive layer of the electrode. The extent of oxidation of the titanium nitride conductive layer is correlated with the extent of formation of oxide of titanium nitride and/or the extent of oxidation of the titanium nitride conductive layer is correlated with the increase of surface roughness. The extent of water decomposition is correlated with formation of hydrogen and oxygen bubbles.

摘要翻译： 本发明提供了在具有设置在基板上的具有氮化钛导电层的电极的表面上减少腐蚀和水分解的方法，并且估计其还原程度。 将电极浸入含有羟基官能化合物的溶液中。 然后，向电极的氮化钛导电层施加电压。 氮化钛导电层的氧化程度与氮化钛的氧化物的形成程度和/或氮化钛导电层的氧化程度与表面粗糙度的增加有关。 水分解的程度与氢气和氧气泡的形成有关。

公开(公告)号：US20110223652A1

公开(公告)日：2011-09-15

申请号：US12723724

申请日：2010-03-15

申请人： Hongbo Peng ,  Gustavo A. Stolovitsky ,  Stephen M. Rossnagel ,  Stanislav Polonsky ,  Binquan Luan ,  Glenn J. Martyna

发明人： Hongbo Peng ,  Gustavo A. Stolovitsky ,  Stephen M. Rossnagel ,  Stanislav Polonsky ,  Binquan Luan ,  Glenn J. Martyna

IPC分类号： G01N33/48 ,  G01N27/447 ,  C12M1/34 ,  H04R17/00

CPC分类号： C12Q1/6869 ,  Y10T29/42 ,  C12Q2565/631

摘要： Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the membrane. The membrane comprises electrical conductive layers, piezoelectric layers, and insulating layers. The piezoelectric layers are operative to control a size of the nanopore for clamping/releasing a polymer as well as to control the thickness of part of the membrane when a voltage is applied to the piezoelectric layers. Combinations of clamping/releasing the polymer and changing the thickness of part of the membrane can move a polymer through the nanopore at any electrically controlled speed and also stretch or break a polymer in the nanopore.

摘要翻译： 提供了利用压电材料通过纳米孔控制聚合物的装置，系统和方法。 形成填充有导电流体的储存器。 形成隔离储存器的膜。 通过膜形成纳米孔。 膜包括导电层，压电层和绝缘层。 压电层可操作以控制用于夹紧/释放聚合物的纳米孔的尺寸，以及当向压电层施加电压时控制膜的一部分的厚度。 夹持/释放聚合物和改变膜的一部分厚度的组合可以以任何电控速度移动聚合物通过纳米孔，并且还拉伸或破坏纳米孔中的聚合物。

公开(公告)号：US20110308949A1

公开(公告)日：2011-12-22

申请号：US12820516

申请日：2010-06-22

申请人： Ali Afzali-Azdakani ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Dennis M. Newns ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Gustavo Stolovitzky

发明人： Ali Afzali-Azdakani ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Dennis M. Newns ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Gustavo Stolovitzky

IPC分类号： G01N27/447 ,  C25B11/00

CPC分类号： G01N27/44756 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0896 ,  B01L2400/0421 ,  B01L2400/0424 ,  B82Y15/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N33/48721

摘要： The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.

摘要翻译： 本发明提供一种纳米流体场有效装置。 该装置包括具有第一侧和第二侧的通道，与第一侧相邻的第一组电极，与第二侧相邻的第二组电极，用于向电极施加电势的控制单元和 该通道含有电荷分子。 第一组电极被布置成使得施加电势产生空间变化的电场，该电场将带电分子限制在所述通道的预定区域内。 第二组电极被布置成使得施加相对于施加到第一组电极的电位的电势产生将带电分子限制在远离通道的第二侧的区域的电场。

公开(公告)号：US08940148B2

公开(公告)日：2015-01-27

申请号：US12820516

申请日：2010-06-22

申请人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Dennis M. Newns ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Gustavo Stolovitzky

发明人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Dennis M. Newns ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Gustavo Stolovitzky

IPC分类号： B03C5/02 ,  G01N33/487 ,  B01L3/00 ,  B82Y15/00

CPC分类号： G01N27/44756 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0896 ,  B01L2400/0421 ,  B01L2400/0424 ,  B82Y15/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N33/48721

摘要： The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.

摘要翻译： 本发明提供一种纳米流体场有效装置。 该装置包括具有第一侧和第二侧的通道，与第一侧相邻的第一组电极，与第二侧相邻的第二组电极，用于向电极施加电势的控制单元和 该通道含有电荷分子。 第一组电极被布置成使得施加电势产生空间变化的电场，该电场将带电分子限制在所述通道的预定区域内。 第二组电极被布置成使得施加相对于施加到第一组电极的电位的电势产生将带电分子限制在远离通道的第二侧的区域的电场。

公开(公告)号：US08641877B2

公开(公告)日：2014-02-04

申请号：US13570470

申请日：2012-08-09

申请人： Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Gustavo A. Stolovitzky

发明人： Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Gustavo A. Stolovitzky

IPC分类号： G01N27/26 ,  C07H21/04 ,  B01J19/08

CPC分类号： B82Y15/00 ,  C12Q1/6806 ,  C12Q2523/303 ,  C12Q2565/631

摘要： Apparatus, system, and method are provided for cutting a linear charged polymer inside a nanopore. A first voltage is applied to create an electric field in a first direction. A second voltage is applied to create an electric field in a second direction, and the first direction is opposite to the second direction. When the electric field in the first direction and the electric field in the second direction are applied to a linear charged polymer inside a nanopore, the linear charged polymer is cut at a location with predetermined accuracy.

摘要翻译： 提供了用于在纳米孔内切割线性带电聚合物的装置，系统和方法。 施加第一电压以在第一方向上产生电场。 施加第二电压以在第二方向上产生电场，并且第一方向与第二方向相反。 当将第一方向的电场和第二方向的电场施加到纳米孔内的线性带电聚合物时，线性带电聚合物在预定精度的位置被切割。

公开(公告)号：US10040682B2

公开(公告)日：2018-08-07

申请号：US13465280

申请日：2012-05-07

申请人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

发明人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

IPC分类号： G01N27/40 ,  B82Y30/00 ,  B82Y40/00 ,  F03B11/02 ,  B82Y15/00 ,  G01N27/00

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N27/00 ,  Y10T137/8593

摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.

公开(公告)号：US10029915B2

公开(公告)日：2018-07-24

申请号：US13439265

申请日：2012-04-04

申请人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

发明人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

IPC分类号： G01N27/40 ,  B82Y30/00 ,  B82Y40/00 ,  F03B11/02 ,  B82Y15/00 ,  G01N27/00

摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.