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27 条记录 (耗时 0.027 秒)

    Advanced coating apparatus and method
    14.
    发明申请
    Advanced coating apparatus and method 有权
    先进的涂装设备及方法

    公开(公告)号：US20060165872A1

    公开(公告)日：2006-07-27

    申请号：US11388478

    申请日：2006-03-24

    申请人： Ralph Chappa ,  Mark Carlson

    发明人： Ralph Chappa ,  Mark Carlson

    IPC分类号： A61L33/00 ,  B05D3/00 ,  B05D7/00

    CPC分类号： B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

    摘要： A method for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.

    摘要翻译： 描述了一种包括具有一对辊和喷嘴的装置旋转器的可卷绕装置的方法。 喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。 在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

    Medical devices and methods for producing the same
    15.
    发明申请
    Medical devices and methods for producing the same 有权
    医疗器械及其制造方法

    公开(公告)号：US20050196424A1

    公开(公告)日：2005-09-08

    申请号：US11102465

    申请日：2005-04-08

    申请人： Ralph Chappa

    发明人： Ralph Chappa

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61L2/00 ,  A61F2/00 ,  A61M31/00

    CPC分类号： A61L31/10 ,  A61F9/0017 ,  A61K9/0051 ,  A61K31/58 ,  C08L31/04 ,  C08L33/10

    摘要： Embodiments of the invention include coated medical devices that can elute one or more bioactive agents within the body, and methods for producing the same. In an embodiment, the invention includes a method of forming a coated medical device including depositing a coated composition onto a medical device having a roughened segment and a smooth segment. In an embodiment, the invention includes a method of forming a coated implantable medical device including depositing a coated composition onto a medical device having a body segment and a piercing segment. In an embodiment, the invention includes a medical device, a coated composition provided on the substrate surface, the composition including a bioactive agent and a polymer. The medical device includes an uncoated component wherein the edge of the coated composition is within 0.5 mm of the uncoated component. In an embodiment, the invention includes a method for disposing a coated composition on a medical device with an ultrasonically atomized spray stream including moving a spray stream in a pattern having a plurality of transverse sweeps and a plurality of longitudinal movements.

    摘要翻译： 本发明的实施方案包括可以洗脱身体内的一种或多种生物活性剂的涂覆的医疗装置及其制备方法。 在一个实施方案中，本发明包括形成涂覆的医疗装置的方法，包括将涂覆的组合物沉积在具有粗糙部分和平滑部分的医疗装置上。 在一个实施方案中，本发明包括形成涂覆的可植入医疗装置的方法，包括将涂覆的组合物沉积到具有身体部分和刺穿部分的医疗装置上。 在一个实施方案中，本发明包括医疗装置，设置在基材表​​面上的涂布组合物，所述组合物包含生物活性剂和聚合物。 医疗装置包括未涂覆的组分，其中涂覆组合物的边缘在未涂覆组分的0.5mm以内。 在一个实施方案中，本发明包括用超声波雾化喷雾流将医用装置上的涂覆组合物设置为包括使具有多个横向扫描和多个纵向移动的图案移动喷雾流的方法。

    Method and apparatus for coating of substrates
    16.
    发明申请
    Method and apparatus for coating of substrates 有权
    用于涂布基材的方法和装置

    公开(公告)号：US20050158449A1

    公开(公告)日：2005-07-21

    申请号：US10976348

    申请日：2004-10-27

    申请人： Ralph Chappa

    发明人： Ralph Chappa

    IPC分类号： B05B13/02 ,  B05B13/04 ,  B05D3/00 ,  B05C5/00

    CPC分类号： B05D1/02 ,  B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05C13/025 ,  B05D1/002 ,  Y10S118/11

    摘要： The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.

    摘要翻译： 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。

    Devices, articles, coatings, and methods for controlled active agent release
    17.
    发明申请
    Devices, articles, coatings, and methods for controlled active agent release 审中-公开
    用于控制活性剂释放的装置，制品，涂料和方法

    公开(公告)号：US20050281858A1

    公开(公告)日：2005-12-22

    申请号：US11156245

    申请日：2005-06-17

    申请人： Tim Kloke ,  Ralph Chappa

    发明人： Tim Kloke ,  Ralph Chappa

    IPC分类号： A61K9/46 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

    CPC分类号： A61L27/40 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/12 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08

    摘要： The present invention relates to multi-layer coatings and device, articles, and methods regarding the same, for controlled active agent release. Embodiments of the present invention include devices, articles, coatings, and methods relating to an composition including an active agent, a first layer disposed on the composition, and a second layer disposed on the first layer, wherein the second layer is configured to provide controlled release of the active agent through the second layer and the second layer has release characteristics that are distinct from the first layer.

    摘要翻译： 本发明涉及用于受控活性剂释放的多层涂层及其相关的装置，制品和方法。 本发明的实施方案包括与包含活性剂的组合物，设置在组合物上的第一层和设置在第一层上的第二层相关的装置，制品，涂层和方法，其中第二层被配置为提供受控的 活性剂通过第二层和第二层的释放具有与第一层不同的释放特性。

    Methods, devices, and coatings for controlled active agent release
    19.
    发明申请
    Methods, devices, and coatings for controlled active agent release 有权
    用于控制活性剂释放的方法，装置和涂层

    公开(公告)号：US20060057277A1

    公开(公告)日：2006-03-16

    申请号：US11223811

    申请日：2005-09-09

    申请人： Ralph Chappa

    发明人： Ralph Chappa

    IPC分类号： A61K6/083 ,  A61L33/00

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602

    摘要： The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.

    摘要翻译： 本发明涉及方法，装置和涂层，其中通过涂层或材料的沉积速率确定活性剂释放。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括鉴定以多种涂布沉积速率施加到基材上的涂料组合物的活性剂洗脱速率，选择一种涂布沉积速率，以及将涂料组合物施用于 医疗器械以选定的沉积速率。 在一个实施方案中，本发明包括一种组合，其包括医疗装置和用于用活性剂涂覆医疗装置的表面的组合物，使得当植入体内时涂覆表面随时间推移释放活性剂。

    Method and Apparatus for Coating of Substrates
    20.
    发明申请
    Method and Apparatus for Coating of Substrates 有权
    基材涂层方法及装置

    公开(公告)号：US20070101933A1

    公开(公告)日：2007-05-10

    申请号：US11539443

    申请日：2006-10-06

    申请人： Ralph Chappa

    发明人： Ralph Chappa

    IPC分类号： B05B5/025

    CPC分类号： B05D1/02 ,  B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05C13/025 ,  B05D1/002 ,  Y10S118/11

    摘要： The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bidirectional rotation member. In an embodiment, the invention includes a method with a bidirectional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.

    摘要翻译： 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。