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23 条记录 (耗时 0.047 秒)

    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof
    11.
    发明申请
    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof 有权
    DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和INTEGRIN ALPHA SUBUNIT蛋白质和核酸分子及其用途

    公开(公告)号：US20090286956A1

    公开(公告)日：2009-11-19

    申请号：US11974478

    申请日：2007-10-12

    申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    IPC分类号： C07K14/705

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Nucleic acid molecules derived from a brain tissue library
    12.
    发明授权
    Nucleic acid molecules derived from a brain tissue library 失效
    衍生自脑组织库的核酸分子

    公开(公告)号：US5969123A

    公开(公告)日：1999-10-19

    申请号：US36089

    申请日：1998-03-06

    申请人： Douglas A. Holtzman

    发明人： Douglas A. Holtzman

    IPC分类号： C07K14/47 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K14/47

    摘要： The invention provides nucleic acid molecules derived from a brain tissue library. The nucleic acid molecules are used in applications such as diagnostic methods, screening assays and as hybridization probes and primers.

    摘要翻译： 本发明提供衍生自脑组织文库的核酸分子。 核酸分子用于诊断方法，筛选试验和杂交探针和引物等应用中。

    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses
    13.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses 审中-公开
    编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新型基因

    公开(公告)号：US20080293077A1

    公开(公告)日：2008-11-27

    申请号：US12214717

    申请日：2008-06-20

    申请人： Douglas A. Holtzman ,  David P. Gearing ,  Yang Pan

    发明人： Douglas A. Holtzman ,  David P. Gearing ,  Yang Pan

    IPC分类号： G01N33/53 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K14/00 ,  C07K16/18 ,  C12P21/04 ,  G01N33/566 ,  G01N33/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/475 ,  C07K14/52 ,  C07K14/705 ,  C12N2799/027 ,  Y02A50/411 ,  Y10T436/143333

    摘要： The invention relates to the discovery and characterization of several genes and the polypeptides they encode: thymotaxin (Tango-45), Tango-63d, Tango-63e, Tango-67, and huchordin (Tango-66). Thymotaxin is a new member of the C-C family of chemokines. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily. Tango-67 is related to a number of growth factors, particularly members of the connective tissue growth factor family. Huchordin is related to chordin, a known protein that is involved in the induction of twinned axes, can completely rescue axial development in ventralized embryos, is a potent dorsalizing factor, and plays a crucial role in regulating cell-cell interactions in the organizing centers of head, trunk, and tail development. The invention encompasses nucleic acid molecules encoding nucleic acids and polypeptides of the invention, or mutant forms thereof that encode dysfunctional receptor polypeptides, vectors containing these nucleic acid molecules, cells harboring recombinant DNA molecules encoding nucleic acids or polypeptides of the invention, or mutant forms thereof, host fusion proteins that include functional or dysfunctional polypeptides of the invention, transgenic animals that express nucleic acids or polypeptides of the invention, screening methods and therapeutic methods employing the nucleic acid molecules and polypeptides described above, substantially purified nucleic acids and polypeptides of the invention, and therapeutic compositions containing these nucleic acid molecules and polypeptides.

    摘要翻译： 本发明涉及几种基因及其编码的多肽的发现和表征：胸腺素（Tango-45），Tango-63d，Tango-63e，Tango-67和huchordin（Tango-66）。 胸腺激素是C-C家族趋化因子的新成员。 Tango-63d和Tango-63e是肿瘤坏死因子（TNF）受体超家族中的两种新型多肽。 探戈67与一些生长因子有关，特别是结缔组织生长因子家族成员。 Huchordin与参与诱导孪生轴的已知蛋白质有关，可以完全消除腹侧胚胎的轴向发育，是一种强有力的背景因子，在调节组织中心的细胞 - 细胞相互作用中起关键作用 头，躯干和尾巴发展。 本发明包括编码本发明的核酸和多肽的核酸分子，或其编码功能障碍受体多肽的突变形式，含有这些核酸分子的载体，携带编码本发明的核酸或多肽的重组DNA分子的细胞，或其突变形式 ，包括本发明的功能性或功能失调多肽的宿主融合蛋白，表达本发明的核酸或多肽的转基因动物，使用上述核酸分子和多肽的筛选方法和治疗方法，本发明的基本纯化的核酸和多肽 以及含有这些核酸分子和多肽的治疗组合物。

    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
    16.
    发明申请
    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof 审中-公开
    DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和整合素α亚基蛋白和核酸分子及其用途

    公开(公告)号：US20080220495A1

    公开(公告)日：2008-09-11

    申请号：US11974465

    申请日：2007-10-12

    申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    IPC分类号： C12N11/00 ,  C07K16/00 ,  C07K17/00

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    LRSG protein and nucleic acid molecules and uses therefor
    17.
    发明授权
    LRSG protein and nucleic acid molecules and uses therefor 失效
    LRSG蛋白和核酸分子及其用途

    公开(公告)号：US06225085B1

    公开(公告)日：2001-05-01

    申请号：US09063950

    申请日：1998-04-21

    申请人： Douglas A. Holtzman

    发明人： Douglas A. Holtzman

    IPC分类号： C12P2106

    CPC分类号： C07K14/4702

    摘要： Novel LRSG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length LRSG proteins, the invention further provides isolated LRSG fusion proteins, antigenic peptides and anti-LRSG antibodies. The invention also provides LRSG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a LRSG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的LRSG多肽，蛋白质和核酸分子。 除了分离的全长LRSG蛋白，本发明还提供了分离的LRSG融合蛋白，抗原肽和抗LRSG抗体。 本发明还提供了LRSG核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和引入或破坏了LRSG基因的非人转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Molecules of the follistatin-related protein family and uses therefor
    18.
    发明授权
    Molecules of the follistatin-related protein family and uses therefor 失效
    卵泡抑素相关蛋白家族的分子及其用途

    公开(公告)号：US5942420A

    公开(公告)日：1999-08-24

    申请号：US972008

    申请日：1997-11-17

    申请人： Douglas A. Holtzman

    发明人： Douglas A. Holtzman

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12P21/06 ,  C07H21/02 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C07K16/18 ,  C07K14/4703 ,  A01K2217/05 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

    摘要： Novel FMCP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FMCP proteins, the invention further provides isolated FMCP fusion proteins, antigenic peptides and anti-FMCP antibodies. The invention also provides FMCP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FMCP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的FMCP多肽，蛋白质和核酸分子。 除了分离的全长FMCP蛋白之外，本发明还提供了分离的FMCP融合蛋白，抗原肽和抗FMCP抗体。 本发明还提供了FMCP核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中FMCP基因被引入或破坏的非人转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。