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公开(公告)号:US20140180395A1
公开(公告)日:2014-06-26
申请号:US14148706
申请日:2014-01-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor: Benjamin M. Wu , Arnold Suwarnasarn , Fernando Vinuela , Ichiro Yuki
IPC: A61F2/82
CPC classification number: A61F2/82 , A61B17/12113 , A61B17/1215 , A61B2017/00004 , A61B2017/00526 , A61B2017/00893 , A61L31/10 , A61L31/16 , A61L2420/02 , C08L67/04
Abstract: An endovascular spiral coil coating and methods of making and using the same.
Abstract translation: 血管内螺旋线圈涂层及其制造和使用方法。
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公开(公告)号:US20220001019A1
公开(公告)日:2022-01-06
申请号:US16839717
申请日:2020-04-03
Applicant: The Regents of the University of California
Inventor: B. Chia Soo , Kang Ting , Benjamin M. Wu
Abstract: The present invention discloses a random conjugate molecule (CMN), comprising a formula of CG-X-N and methods of making and using the same. The present invention also discloses a composition comprising the CMN and methods of making and using the composition.
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公开(公告)号:US20190275160A1
公开(公告)日:2019-09-12
申请号:US16084525
申请日:2017-03-14
Applicant: The Regents of the University of California
Inventor: B. Chia Soo , Ting Kang , Benjamin M. Wu
Abstract: The present invention discloses a bone-targeting therapeutic conjugate comprising a formula of TG-M-D (I) or M-D-TG (II) and methods of making and using the same. The present invention also discloses a composition comprising the conjugate and methods of making and using the composition.
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公开(公告)号:US10391310B2
公开(公告)日:2019-08-27
申请号:US15470542
申请日:2017-03-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor: Wentai Liu , James C. Y. Dunn , Benjamin M. Wu , Yi-Kai Lo , Chih-Wei Chang , Justin P. Wagner
Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.
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15.
公开(公告)号:US20180259521A1
公开(公告)日:2018-09-13
申请号:US15756542
申请日:2016-09-02
Applicant: The Regents of the University of California
Inventor: Daniel T. Kamei , Yin To Chiu , Benjamin M. Wu , Garrett L. Mosley
IPC: G01N33/569 , G01N33/493 , G01N33/49 , G01N33/483
CPC classification number: G01N33/56927 , G01N33/4833 , G01N33/49 , G01N33/493 , G01N33/558 , G01N33/569 , G01N33/56944 , G01N33/56961 , G01N33/56983
Abstract: In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×106 cells/mL, less than about 3×106 cells/ml, less than about 1×106 CFU/mL, or less than about 50 μg/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.
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16.
公开(公告)号:US12280372B2
公开(公告)日:2025-04-22
申请号:US17605925
申请日:2020-04-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor: Pei Yu E. Chiou , Kuan-Wen Tung , Benjamin M. Wu
Abstract: The present invention relates to a near-field acoustic platform capable of synthesizing high resolution, arbitrarily shaped energy potential wells. A thin and viscoelastic membrane is utilized to modulate acoustic wavefront on a deep, sub-wavelength scale by suppressing the structural vibration selectively on the platform. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products.
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17.
公开(公告)号:US20220203359A1
公开(公告)日:2022-06-30
申请号:US17605925
申请日:2020-04-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor: Pei Yu E. Chiou , Kuan-Wen Tung , Benjamin M. Wu
IPC: B01L3/00
Abstract: The present invention relates to a near-field acoustic platform capable of synthesizing high resolution, arbitrarily shaped energy potential wells. A thin and viscoelastic membrane is utilized to modulate acoustic wavefront on a deep, sub-wavelength scale by suppressing the structural vibration selectively on the platform. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products.
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公开(公告)号:US10335458B2
公开(公告)日:2019-07-02
申请号:US15367097
申请日:2016-12-01
Applicant: The Regents of the University of California
Inventor: Chia Soo , Kang Ting , Shunichi Kuroda , Benjamin M. Wu
IPC: A61K35/32 , A61K38/17 , A61L27/22 , A61K31/728
Abstract: Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same.
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公开(公告)号:US20190033308A1
公开(公告)日:2019-01-31
申请号:US15990398
申请日:2018-05-25
Applicant: The Regents of the University of California
Inventor: Daniel T. Kamei , Yin To Chiu , Benjamin M. Wu , Garrett L. Mosley
IPC: G01N33/558 , G01N33/543
CPC classification number: G01N33/558 , G01N33/54366 , G01N33/54386
Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
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20.
公开(公告)号:US20150094518A1
公开(公告)日:2015-04-02
申请号:US14498005
申请日:2014-09-26
Applicant: The Regents of the University of California
Inventor: Benjamin M. Wu , Maie A.R. St. John , Arnold Suwarnasam , Linda Wang , Yuan Lin , Jie Luo , Eric Zhu , Ontario D. Lau
CPC classification number: A61N5/10 , A61K9/0024 , A61K9/06 , A61K31/4745 , A61K31/713 , A61K31/716 , A61K35/00 , A61K38/00 , A61K45/06 , A61K47/34 , A61N2005/1098 , C07K17/06 , G01N33/57407 , G01N2800/52 , A61K2300/00
Abstract: The invention provides a novel polymer platform to deliver a desired combination of therapeutic agents to a site in need thereof for the treatment of cancer. In certain embodiments the platform is a modular polymer platform that allows for customization based upon the tumor of the subject to be treated.
Abstract translation: 本发明提供了一种新颖的聚合物平台,用于将治疗剂的期望组合递送至需要其的部位用于治疗癌症。 在某些实施方案中,平台是模块化聚合物平台,其允许基于要治疗的受试者的肿瘤的定制。
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