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11.发明申请公开(公告)号：US20060257658A1
公开(公告)日：2006-11-16
申请号：US10568680
申请日：2004-03-25
Applicant: Junzo Tanaka , Toshiyuki Ikoma , Tetsushi Taguchi
Inventor： Junzo Tanaka , Toshiyuki Ikoma , Tetsushi Taguchi
CPC classification number: B01J20/3204 , B01J20/048 , B01J20/28004 , B01J20/28019 , B01J20/282 , B01J20/286 , B01J20/3236 , B01J20/3272 , B01J20/3293 , C01B25/32 , Y10T428/2982 , Y10T428/2991
Abstract: A porous and spherical calcium phosphate particle which is substituted with a metal ion or has a metal ion carried on the surface thereof, and has a particle diameter of 0.1 to 100 μm. The calcium phosphate particle is a novel functional particle which is useful, for example, as a material for use in gas chromatography allowing the separation of a chemical substance of a trace amount with high accuracy.
Abstract translation: 一种由金属离子取代或在其表面承载有金属离子的多孔和球形磷酸钙颗粒，其粒径为0.1-100微米。 磷酸钙颗粒是新的功能性颗粒，其可用作例如用于气相色谱的材料，其允许以高精度分离微量的化学物质。
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公开(公告)号：US09499728B2
公开(公告)日：2016-11-22
申请号：US13877880
申请日：2011-10-04
Applicant: Tetsushi Taguchi , Miyuki Matsuda
Inventor： Tetsushi Taguchi , Miyuki Matsuda
IPC: C09J189/00 , C09H7/00 , A61L24/10 , A61K38/00
CPC classification number: C09J189/00 , A61L24/104
Abstract: The present invention addresses the problem of providing: a two-component tissue adhesive having high adhesive strength and high biocompatibility; and a method for producing the two-component tissue adhesive. The present invention involves a two-component tissue adhesive comprising hydrophobically-modified gelatin as a first agent and a cross-linking reagent as a second agent. The hydrophobically-modified gelatin is provided with an amino group and a hydrophobic group on the side chain thereof, and the cross-linking reagent has two or more active ester groups or anhydrides within a single molecule.
Abstract translation: 本发明解决了提供：具有高粘合强度和高生物相容性的双组分组织粘合剂的问题; 以及双组分组织粘合剂的制造方法。 本发明涉及包含疏水改性明胶作为第一试剂的双组分组织粘合剂和作为第二试剂的交联剂。 疏水改性的明胶在其侧链上具有氨基和疏水性基团，交联剂在单分子内具有两个以上的活性酯基或酸酐。
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公开(公告)号：US20130304184A1
公开(公告)日：2013-11-14
申请号：US13988870
申请日：2011-11-25
Applicant: Tetsushi Taguchi , Yasuyuki Katada , Ryozo Nagai , Ichiro Manabe , Katsuhito Fujiu
Inventor： Tetsushi Taguchi , Yasuyuki Katada , Ryozo Nagai , Ichiro Manabe , Katsuhito Fujiu
IPC: A61F2/82
CPC classification number: A61F2/82 , A61L31/022 , C22C38/001 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/22 , C22C38/26 , C22C38/28 , C22C38/32 , C22C38/44
Abstract: A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30% by mass of Cr, from 0.97 to 2% by mass of Mo, and from 0.5 to 1% by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.
Abstract translation: 使用不锈钢不含镍的不含镍的不锈钢支架，具有金属过敏起效防止效果，并且在精加工性，强度和延展性方面优异。 无镍不锈钢支架的特征在于，使用含有15〜30质量％的Cr，0.97〜2质量％的Mo和0.5〜1质量％的作为化学组成的不锈钢， N，其余为Fe，并且任选地含有不可避免的杂质。
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公开(公告)号：US20130245240A1
公开(公告)日：2013-09-19
申请号：US13989279
申请日：2011-11-24
Applicant: Tetsushi Taguchi , Makoto Sasaki , Yasuyuki Katada
Inventor： Tetsushi Taguchi , Makoto Sasaki , Yasuyuki Katada
CPC classification number: C07K17/14 , A61F2/82 , A61L31/022 , A61L31/16 , A61L2300/414 , A61L2300/426
Abstract: Provided is a bio-hybrid material that does not cause elution of nickel ions and has an excellent endothelialization ability, a production method therefor, and a stent. The bio-hybrid material (101) used includes an alloy part (11) free of Ni, an organic acid (12) having two or more active esters, and a cytokine (13). The alloy part (11) free of Ni forms an ester bond with the organic acid (12), and the organic acid (12) and the cytokine (13) are immobilized via an amide bond.
Abstract translation: 提供了不引起镍离子洗脱并具有优异的内皮化能力的生物混合材料，其制备方法和支架。 使用的生物混合材料（101）包括不含Ni的合金部分（11），具有两种以上活性酯的有机酸（12）和细胞因子（13）。 不含Ni的合金部分（11）与有机酸（12）形成酯键，有机酸（12）和细胞因子（13）通过酰胺键固定。
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公开(公告)号：US20130045277A1
公开(公告)日：2013-02-21
申请号：US13576718
申请日：2011-02-01
Applicant: Tetsushi Taguchi , Yasuyuki Katada , Ryozo Nagai , Ichiro Manabe , Katsuhito Fujiu
Inventor： Tetsushi Taguchi , Yasuyuki Katada , Ryozo Nagai , Ichiro Manabe , Katsuhito Fujiu
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/602
Abstract: Disclosed is a biocompatible device surface-coated on the base material thereof with a biocompatible polymer layer having antithrombogenicity and endothelialization activity, and embedded in or attached to a living body for use. The polymer layer comprises a polymer matrix formed by the crosslinking of a cell-adhesive peptide-containing polymer.
Abstract translation: 公开了一种在其基材上表面涂覆有生物相容性聚合物层的生物相容性装置，其具有抗血栓形成和内皮化活性，并且嵌入或附着于生物体使用。 聚合物层包含通过含细胞粘着肽的聚合物交联而形成的聚合物基质。
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Patent Agency Ranking
公开(公告)号：US07871638B2
公开(公告)日：2011-01-18
申请号：US10516818
申请日：2003-05-02
Applicant: Junzo Tanaka , Tetsushi Taguchi
Inventor： Junzo Tanaka , Tetsushi Taguchi
CPC classification number: A61L27/3839 , A61L27/46 , C08L5/00
Abstract: This invention relates to a scaffold consisting of a biodegradable polymeric material with a composition gradient of calcium phosphate that is capable of effectively regenerating the hard/soft tissue interface and an implant for hard/soft tissue filling with the utilization of such scaffold.
Abstract translation: 本发明涉及由能够有效地再生硬/软组织界面的具有磷酸钙组成梯度的可生物降解的聚合物材料和用于硬/软组织填充以利用这种支架的植入物构成的支架。
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公开(公告)号：US07741454B2
公开(公告)日：2010-06-22
申请号：US10527694
申请日：2003-09-11
Applicant: Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
Inventor： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
IPC: C07K1/00 , C07K14/00 , C07K17/00 , C07K16/00 , C08H1/00 , A61F2/00 , A61K31/74 , A61F13/15 , A61F13/20
CPC classification number: C07D207/02 , C07D207/46
Abstract: The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
Abstract translation: 已经用于生物粘合剂和治疗医疗装置如心脏瓣膜的交联剂和缩合剂是人工合成的非天然化合物。 因此，它们不会在体内代谢并对活体表现出毒性。 因此，这些化合物仅在临床部位中仅限于有限的目的和用途。 本发明提供一种通过用N-羟基琥珀酰亚胺，N-羟基磺基琥珀酰亚胺或其衍生物修饰生物低分子量化合物的羧基得到的生物学低分子量衍生物和通过以下方法得到的交联的高分子量产物： 用该衍生物交联各种高分子量化合物。
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公开(公告)号：US20060239958A1
公开(公告)日：2006-10-26
申请号：US10543156
申请日：2004-02-05
Applicant: Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
Inventor： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Hirofumi Saito
CPC classification number: A61L24/043 , A61L24/0042 , A61L2430/36
Abstract: Disclosed is a two-component, bio-degradable/absorbable adhesive medical material, which has a bonding component comprising a biodegradable polymer, and a hardening component comprising a low-molecular-weight derivative prepared by modifying a carboxyl group in a di- or tri-carboxylic acid of the citric acid cycle, with an electron-attracting group (one or a combination of two or more selected from the group consisting of a succinimidyl group, a sulfosuccinimidyl group, a maleimidyl group, a phthalimidyl group, an imidazolyl group, a nitrophenyl group and a tresyl group, and derivatives thereof). The present invention is intended to meet the need for developing a biological tissue adhesive having strong bonding force and low biological toxicity, in the situation where a conventional hemostatic material, blood-vessel embolizing material, sealant or aneurysm closing material has been liable to peel off from its applied site and has not been able to achieve sufficient hemostatic effect or sealing/closing strength in occluding a blood vessel, stopping bleeding, sealing air-leak or closing an aneurysm.
Abstract translation: 公开了一种双组分生物可降解/可吸收的粘合剂医疗材料，其具有包含可生物降解的聚合物的粘合组分和包含通过改性二 - 或三（C）中的羧基制备的低分子量衍生物的硬化组分 - 具有吸电子基团（一种或两种或更多种选自琥珀酰亚胺基，磺基琥珀酰亚胺基，马来酰亚胺基，苯二酰亚胺基，咪唑基，咪唑基， 硝基苯基和甲酚基，及其衍生物）。 本发明旨在满足在常规止血材料，血管栓塞材料，密封剂或动脉瘤闭合材料易于剥离的情况下开发具有强结合力和低生物毒性的生物组织粘合剂的需要 从其应用场所，并且在闭塞血管，停止出血，密封空气泄漏或闭合动脉瘤方面未能达到充分的止血效果或密封/闭合强度。
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19.发明申请公开(公告)号：US20060165663A1
公开(公告)日：2006-07-27
申请号：US10516818
申请日：2003-05-02
Applicant: Junzo Tanaka , Tetsushi Taguchi
Inventor： Junzo Tanaka , Tetsushi Taguchi
CPC classification number: A61L27/3839 , A61L27/46 , C08L5/00
Abstract: This invention relates to a scaffold consisting of a biodegradable polymeric material with a composition gradient of calcium phosphate that is capable of effectively regenerating the hard/soft tissue interface and an implant for hard/soft tissue filling with the utilization of such scaffold.
Abstract translation: 本发明涉及由能够有效地再生硬/软组织界面的具有磷酸钙组成梯度的可生物降解的聚合物材料和用于硬/软组织填充以利用这种支架的植入物构成的支架。
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20.发明申请Glycosaminoglycan-polycation complex crosslinked with polyfunctional crosslinking agent and process for producing the same 审中-公开用多官能交联剂交联的糖胺聚糖聚阳离子配合物及其制备方法公开(公告)号：US20050053576A1
公开(公告)日：2005-03-10
申请号：US10487333
申请日：2002-07-31
Applicant: Junzo Tanaka , Tetsushi Taguchi , Kyosuke Miyazaki , Yoshiyuki Sakura , Tatsuro Ohtsuka , Yoshinobu Mandai
Inventor： Junzo Tanaka , Tetsushi Taguchi , Kyosuke Miyazaki , Yoshiyuki Sakura , Tatsuro Ohtsuka , Yoshinobu Mandai
IPC: A61L27/00 , A61K31/785 , A61L27/20 , A61L27/26 , A61L27/38 , A61L27/44 , A61L27/48 , A61L27/50 , A61P19/02 , C08B37/00 , C08B37/08 , C08G63/91 , C08G65/322 , C08G65/329 , C08G65/333 , C08H1/06
CPC classification number: A61L27/3852 , A61L27/20 , A61L27/26 , A61L27/44 , A61L27/48 , A61L27/50 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08G65/322 , C08G65/329 , C08G65/33337 , C08H1/06 , C08L2203/02 , C08L5/00
Abstract: Disclosed is a glycosaminoglycan-polycation complex as a matrix material for use in tissue regeneration, such as cartilage repair, and a preparation method thereof. The complex is synthesized by crosslinking glycosaminoglycan and polycation with a polyfunctional crosslinking agent under physiological conditions. In this method, the crosslinking agent consists of polyethyleneglycol having two or more electrophilic leaving groups (e.g. succinimidyl group or its derivatives) at the carboxyl terminal thereof, and the concentration of the crosslinking agent is in the range of 0.3 to 3 mM. According the present invention, the crosslinking reaction can be performed under physiological conditions to avoid conventional problems of adverse affect on cells (cell death) and the formation of a polyion complex (inhomogeneous precipitate) due to a crosslinking reaction in alcohol or water. Thus, the crosslinking reaction can be conducted in the presence of cells mixed to the glycosaminoglycan and polycation in advance.
Abstract translation: 公开了作为用于组织再生的基质材料的糖胺聚糖 - 聚阳离子络合物，例如软骨修复及其制备方法。 通过在生理条件下与多官能交联剂交联糖胺聚糖和聚阳离子来合成络合物。 在该方法中，交联剂由在羧基末端具有两个以上亲电离去基团（例如琥珀酰亚胺基或其衍生物）的聚乙二醇组成，交联剂的浓度在0.3〜3mM的范围内。 根据本发明，交联反应可以在生理条件下进行，以避免由于酒精或水中的交联反应而导致对细胞的不利影响（细胞死亡）和聚离子络合物（不均匀沉淀物）的形成的常规问题。 因此，交联反应可以在预先与糖胺聚糖和聚阳离子混合的细胞存在下进行。
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