公开(公告)号：US20240279504A1

公开(公告)日：2024-08-22

申请号：US18465867

申请日：2023-09-12

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Xiaojie Lin ,  Jonathan Himmelfarb ,  Buddy D. Ratner

IPC: C09D133/26 ,  A61L29/04 ,  A61L29/06 ,  A61L29/08 ,  A61L29/14 ,  C08J3/28

CPC classification number: C09D133/26 ,  A61L29/041 ,  A61L29/06 ,  A61L29/085 ,  A61L29/141 ,  C08J3/28 ,  C08J2333/26

Abstract: Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

公开(公告)号：US20230203462A1

公开(公告)日：2023-06-29

申请号：US17767426

申请日：2020-10-09

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zhedfan Yuan ,  Shaoyi Jiang ,  Yanjiao Han ,  Sijin Luozhong

IPC: C12N9/22 ,  C12N15/52 ,  C12N15/113

CPC classification number: C12N9/22 ,  C12N15/52 ,  C12N15/113

Abstract: Provided are compositions and methods for the production of modified endonucleases such as CRISPR/Cas9 system with reduced off-target activity. Methods of editing of polynucleotides using the modified endonucleases in vitro and in vivo are also disclosed. In one aspect, the disclosure provides a modified endonuclease, comprising an endonuclease and one or more mixed charge moieties covalently linked to the endonuclease, wherein each mixed charge moiety comprises about 10 to about 400 positively charged moieties and about 10 to about 400 negatively charged moieties, and wherein the ratio of the number of positively charged moieties to the number of negatively charged moieties is from about 1 :0.5 to about 1 :2.

公开(公告)号：US20210023228A1

公开(公告)日：2021-01-28

申请号：US17040455

申请日：2019-03-25

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Bowen Li ,  Priyesh Jain

IPC: A61K47/58 ,  A61K47/69 ,  A61K38/44 ,  C08F299/00 ,  C07F9/09

Abstract: Zwitterionic phosphatidylserione (ZPS) monomers, ZPS polymers and ZPS copolymers, methods for making the ZPS monomers, ZPS polymers, and ZPS copolymers, compositions and materials that include ZPS polymers and ZPS copolymers, and methods for using the ZPS monomers, ZPS polymers, and ZPS copolymers.

公开(公告)号：US20170266350A1

公开(公告)日：2017-09-21

申请号：US15509607

申请日：2015-09-09

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Shaoyi Jiang ,  Tao Bai ,  Harihara Subramanian Sundaram ,  Andrew William Sinclair ,  Jean-René Ella-Menye ,  Priyesh Jain

IPC: A61L27/52 ,  A61L27/16 ,  A61L27/38 ,  A61L31/10 ,  A61L31/06 ,  C12N5/00 ,  A61L15/24 ,  A61L15/42 ,  A61L24/04 ,  A61L24/00 ,  C08G81/02 ,  C08F220/36 ,  A61K9/00 ,  A61L31/14

CPC classification number: A61L27/52 ,  A61K9/0024 ,  A61K47/58 ,  A61L15/22 ,  A61L15/24 ,  A61L15/42 ,  A61L24/0031 ,  A61L24/046 ,  A61L27/16 ,  A61L27/3804 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  C08F220/36 ,  C08F2220/365 ,  C08G81/021 ,  C12N5/0018 ,  C12N2533/30 ,  C12N2539/00

Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

公开(公告)号：US20170174907A1

公开(公告)日：2017-06-22

申请号：US15394538

申请日：2016-12-29

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Yuting Li ,  Hong Xue ,  Shengfu Chen

IPC: C09D5/16 ,  B63B59/04 ,  C09D153/00 ,  C09D151/08 ,  C09D133/26 ,  C09D183/04

CPC classification number: C09D5/1637 ,  A61K31/785 ,  B63B59/04 ,  C09D5/16 ,  C09D5/1606 ,  C09D5/165 ,  C09D5/1656 ,  C09D5/1662 ,  C09D5/1668 ,  C09D5/1675 ,  C09D133/26 ,  C09D151/085 ,  C09D153/00 ,  C09D183/04 ,  Y10T428/31511 ,  Y10T428/3154 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31844 ,  Y10T428/31938 ,  Y10T428/31942 ,  Y10T442/10

Abstract: Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

公开(公告)号：US20170108492A1

公开(公告)日：2017-04-20

申请号：US15396128

申请日：2016-12-30

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Zheng Zhang ,  Shengfu Chen ,  Hana Vaisocherova

IPC: G01N33/545 ,  G01N33/543 ,  C08F122/22

CPC classification number: G01N33/545 ,  C08F122/22 ,  G01N33/54353

Abstract: Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

公开(公告)号：US09533006B2

公开(公告)日：2017-01-03

申请号：US13692958

申请日：2012-12-03

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Xuewei Xu ,  Yuting Li ,  Andrew Keefe ,  Hong Xue ,  Shengfu Chen

IPC: C08F20/56 ,  A61K31/785 ,  C09D5/16

CPC classification number: C09D5/1637 ,  A61K31/785 ,  B63B59/04 ,  C09D5/16 ,  C09D5/1606 ,  C09D5/165 ,  C09D5/1656 ,  C09D5/1662 ,  C09D5/1668 ,  C09D5/1675 ,  C09D133/26 ,  C09D151/085 ,  C09D153/00 ,  C09D183/04 ,  Y10T428/31511 ,  Y10T428/3154 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31844 ,  Y10T428/31938 ,  Y10T428/31942 ,  Y10T442/10

Abstract: Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

Abstract translation: 海洋涂料包括可水解成非结垢的两性离子聚合物的阳离子聚合物，涂覆的海洋表面，以及用于制造和使用海洋涂料的方法。

公开(公告)号：US11752212B2

公开(公告)日：2023-09-12

申请号：US16627068

申请日：2018-06-29

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Priyesh Jain ,  Jinrong Ma ,  Bowen Li

IPC: A61K47/58 ,  A61K9/51 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C08F220/60 ,  C08J3/075 ,  C09D5/16 ,  C12N5/078 ,  C08F222/22

CPC classification number: A61K47/58 ,  A61K9/5138 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  C08F220/60 ,  C08J3/075 ,  C09D5/16 ,  C12N5/0644 ,  C08F220/603 ,  C08F222/225 ,  C08J2300/206 ,  C08J2333/26 ,  C09D4/00 ,  C08F220/60 ,  C08F220/603 ,  C08F222/385

Abstract: N-oxide and monomers, N-oxide polymers and copolymers, methods for making the N-oxide monomers, polymers, and copolymers, compositions and materials that include N-oxide polymers and copolymers, and methods for using the N-oxide monomers, N-oxide polymers, and N-oxide copolymers.

公开(公告)号：US20210324010A1

公开(公告)日：2021-10-21

申请号：US17283708

申请日：2019-10-10

Applicant: University of Washington

Inventor： Caroline Tsao ,  Sijin Luozhong ,  Trevor Corrigan ,  Shaoyi Jiang ,  Erik Liu ,  Patrick McMullen

IPC: C07K14/00 ,  A61K47/64 ,  C07K14/535 ,  C07K14/56 ,  C07K14/435

Abstract: Charged polypeptides, their conjugates, and fusion proteins comprising such polypeptides are disclosed. Inclusion of such a polypeptide in a fusion protein increases the protein's properties such as stability and circulation half-life, which results in a better therapeutic efficacy compared to an active protein alone. Thus, a fusion protein or a conjugate of the disclosure can be useful in developing a protein or peptide drug, treating or preventing diseases, disorders, or conditions, or improving a subjects health or wellbeing.

公开(公告)号：US20210088535A1

公开(公告)日：2021-03-25

申请号：US17035130

申请日：2020-09-28

Applicant: University of Washington through its Center for Commercialization ,  Bloodworks

Inventor： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC: G01N33/80 ,  G01N33/543 ,  G01N21/77

Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.