公开(公告)号：US20110082113A1

公开(公告)日：2011-04-07

申请号：US12896955

申请日：2010-10-04

Applicant: John Hynes ,  Percy H. Carter ,  Lyndon A.M. Cornelius ,  T.G. Murali Dhar ,  John V. Duncia ,  Joseph B. Santella ,  Hong Wu ,  Satheesh Nair ,  Jayakumar S. Warrier

Inventor： John Hynes ,  Percy H. Carter ,  Lyndon A.M. Cornelius ,  T.G. Murali Dhar ,  John V. Duncia ,  Joseph B. Santella ,  Hong Wu ,  Satheesh Nair ,  Jayakumar S. Warrier

IPC: A61K31/675 ,  C07D211/52 ,  A61K31/451 ,  A61P19/02 ,  A61P29/00 ,  A61P9/04 ,  A61P31/18 ,  A61P17/06 ,  A61P11/06 ,  A61P37/06 ,  A61P35/00 ,  C07D413/12 ,  A61K31/5377 ,  C07F9/113

CPC classification number: C07D211/60 ,  C07D211/52 ,  C07F9/59

Abstract: The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis using the prodrug compounds of the invention are disclosed.

Abstract translation: 本申请描述了式（I）化合物的前药或其立体异构体或其药学上可接受的盐。 此外，公开了使用本发明的前药化合物治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎的方法。

公开(公告)号：US20070093537A1

公开(公告)日：2007-04-26

申请号：US11633337

申请日：2006-12-04

Applicant: John Hynes ,  Hong Wu ,  Katerina Leftheris ,  Chunjian Liu ,  Jagabandhu Das ,  Robert Moquin

Inventor： John Hynes ,  Hong Wu ,  Katerina Leftheris ,  Chunjian Liu ,  Jagabandhu Das ,  Robert Moquin

IPC: A61K31/426

CPC classification number: C07D277/56 ,  C07D417/12

Abstract: The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z1 m and n are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.

Abstract translation: 本发明提供了可用于治疗p38激酶相关病症的式（I）的噻唑基类化合物，其中环A是苯基或吡啶基，X，Y，B，R 2， Z 3，Z 1和Z 3如本文所定义。 本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。

公开(公告)号：US07169771B2

公开(公告)日：2007-01-30

申请号：US10773790

申请日：2004-02-06

Applicant: John Hynes ,  Hong Wu ,  Katerina Leftheris ,  Chunjian Liu ,  Jagabandhu Das ,  Robert V. Moquin

Inventor： John Hynes ,  Hong Wu ,  Katerina Leftheris ,  Chunjian Liu ,  Jagabandhu Das ,  Robert V. Moquin

IPC: A61K31/425 ,  C07D277/20

CPC classification number: C07D277/56 ,  C07D417/12

Abstract: The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z1 m and n are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.

公开(公告)号：US20050143398A1

公开(公告)日：2005-06-30

申请号：US10970420

申请日：2004-10-21

Applicant: Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen Wrobleski ,  Hong Wu

Inventor： Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen Wrobleski ,  Hong Wu

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/02 ,  C07D487/04 ,  C07D495/04

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R 1，R 2，R 2，R 2， R 5，R 6a，R 6b，J，K，X和Z如说明书中所述。

公开(公告)号：US20110288085A1

公开(公告)日：2011-11-24

申请号：US12999073

申请日：2009-06-18

Applicant: John Hynes ,  George V. De Lucca ,  Hong Wu

Inventor： John Hynes ,  George V. De Lucca ,  Hong Wu

IPC: A61K31/437 ,  C07D413/14 ,  A61P29/00 ,  A61K31/5377 ,  A61K31/4985 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D401/04

Abstract: A compound of Formula (I) or Formula (II) and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) or Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

Abstract translation: 式（I）或式（II）的化合物及其对映异构体，非对映异构体及其药学上可接受的盐。 还公开了含有式（I）或式（II）的化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

公开(公告)号：US20110136935A1

公开(公告)日：2011-06-09

申请号：US12675424

申请日：2007-08-30

Applicant: Eugene Khor ,  Chang Ming Guo ,  Hong Wu ,  Lee Yong Lim

Inventor： Eugene Khor ,  Chang Ming Guo ,  Hong Wu ,  Lee Yong Lim

IPC: A61K6/083 ,  A61Q11/00

CPC classification number: C08F290/06 ,  A61K6/0067 ,  A61K6/0085 ,  A61L24/0015 ,  A61L24/0084 ,  A61L24/10 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/428 ,  A61L2300/64 ,  A61L2430/02 ,  C08F251/00 ,  C08F251/02 ,  C08F283/00 ,  C08F283/06 ,  C08F290/061 ,  C08F290/062 ,  C08L51/02 ,  C08L53/00 ,  C08L5/08 ,  C08L2666/02 ,  A61K6/097 ,  A61K6/087 ,  C08L33/14 ,  C08L89/00 ,  C08L71/02 ,  C08L29/04 ,  C08L1/286 ,  C08L1/284 ,  A61K6/083 ,  A61K6/0038 ,  A61K6/0041

Abstract: The present invention provides a composition comprising: at least one viscosity-enhancing agent; and at least one macromonomer. In particular, the composition may be a bone cement composition and/or a dental cement composition. The composition may be used in medicine. The composition may be used in orthopedic and/or periodontal applications. The present invention also provides uses of the composition.

Abstract translation: 本发明提供一种组合物，其包含：至少一种粘度增强剂; 和至少一种大分子单体。 特别地，组合物可以是骨水泥组合物和/或牙科粘固剂组合物。 该组合物可用于医药。 该组合物可用于矫形和/或牙周应用。 本发明还提供了组合物的用途。

公开(公告)号：US07642257B2

公开(公告)日：2010-01-05

申请号：US12047550

申请日：2008-03-13

Applicant: Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen T. Wrobleski ,  Hong Wu

Inventor： Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen T. Wrobleski ,  Hong Wu

IPC: C07D487/04 ,  A61K31/4985 ,  A61P19/02

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R，R1，R2，R5，R6a，R6b，J，K，X和Z如 规范。

公开(公告)号：US07419978B2

公开(公告)日：2008-09-02

申请号：US10970420

申请日：2004-10-21

Applicant: Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen T. Wrobleski ,  Hong Wu

Inventor： Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen T. Wrobleski ,  Hong Wu

IPC: C07D487/04 ,  C07D487/14 ,  A61K31/53 ,  A61P19/02 ,  A61P19/10

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R 1，R 2，R 2，R 2， R 5，R 6a，R 6b，J，K，X和Z如说明书中所述。

公开(公告)号：US20060064768A1

公开(公告)日：2006-03-23

申请号：US10946894

申请日：2004-09-21

Applicant: Hong Wu ,  Xin Lu ,  Shunyou Wang

Inventor： Hong Wu ,  Xin Lu ,  Shunyou Wang

IPC: A01K67/027

CPC classification number: C12N9/16 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/008

Abstract: The invention provides a transgenic mouse and cell lines with a homozygous disruption of a chromosomal PTEN gene in prostate cells. The mouse progresses from hyperplasia to metastatic cancer and can be used to identify prostate cancer therapeutics and genes that are differentially regulated during androgen dependent and androgen independent prostate cancer progression.

Abstract translation: 本发明提供了转基因小鼠和在前列腺细胞中染色体PTEN基因纯合破坏的细胞系。 小鼠从增生进展到转移性癌症，并且可以用于鉴定在雄激素依赖性和雄激素依赖性前列腺癌进展期间差异调节的前列腺癌治疗剂和基因。

公开(公告)号：US20050211549A1

公开(公告)日：2005-09-29

申请号：US10810534

申请日：2004-03-26

Applicant: Hui Chang ,  Chang Chao ,  Hong Wu

Inventor： Hui Chang ,  Chang Chao ,  Hong Wu

IPC: C23C14/32 ,  C23C14/34 ,  H01L21/203 ,  H01L21/66

CPC classification number: H01J37/3482 ,  C23C14/3407

Abstract: A method and system for determining a lifetime of a target for a physical vapor deposition tool (302), has, a mapping table (304a) of criteria for a minimum accumulating rate of Δ wafers fabricated by Δ target life for a target in the tool; and a database (304) recording Δ wafers fabricated by Δ target life for a target in the tool; and a computer (306) retrieving the criteria from the mapping table and entering the criteria in the database; and the tool (302) reporting Δ wafers fabricated by Δ target life for a target in the tool (302) for comparison with the criteria.

Abstract translation: 一种用于确定物理气相沉积工具（302）的靶的寿命的方法和系统，具有用于针对目标的达标目标寿命制造的三角形晶片的最小累积速率的标准的映射表（304a） 工具; 以及数据库（304），记录用于所述工具中的目标的达标目标寿命制造的三角形晶片; 以及计算机（306），其从所述映射表检索所述准则并在所述数据库中输入所述准则; 并且所述工具（302）报告通过所述工具（302）中的目标的达标目标寿命制造的三角形晶片以与所述准则进行比较。