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公开(公告)号：US20080252897A1
公开(公告)日：2008-10-16
申请号：US11596141
申请日：2005-05-17
Applicant: Borkur Arnvidarson , Hans Larsen
Inventor： Borkur Arnvidarson , Hans Larsen
CPC classification number: G01J3/45 , G01J3/0202 , G01J3/453 , G01N21/35 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N2021/3595 , G01N2201/0691 , G01N2201/129
Abstract: The present invention offers an alternative strategy for the correlation of interference information to chemical and/or physical properties of a sample. This strategy can be implemented in a method and a system, which offer substantial technical and commercial advantages over state of the art techniques based on interference spectroscopy. The invention further provides a method for standardizing an interferometer, as well as a method and a system using the standardized
Abstract translation: 本发明提供了用于将干扰信息与样品的化学和/或物理性质相关的替代策略。 该策略可以在与基于干涉光谱技术的现有技术相比提供实质的技术和商业优势的方法和系统中实现。 本发明还提供了一种用于标准化干涉仪的方法，以及使用标准化的方法和系统
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公开(公告)号：US20080248965A1
公开(公告)日：2008-10-09
申请号：US12062282
申请日：2008-04-03
Applicant: Frans Ejner Rvan Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
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公开(公告)号：US07068365B2
公开(公告)日：2006-06-27
申请号：US11130717
申请日：2005-05-17
Applicant: Frans Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
Inventor： Frans Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
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公开(公告)号：US10254223B2
公开(公告)日：2019-04-09
申请号：US15879696
申请日：2018-01-25
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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公开(公告)号：US09903819B2
公开(公告)日：2018-02-27
申请号：US14473020
申请日：2014-08-29
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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Patent Agency Ranking
公开(公告)号：US08259300B2
公开(公告)日：2012-09-04
申请号：US12596206
申请日：2008-04-21
Applicant: Börkur Arnvidarson
Inventor： Börkur Arnvidarson
IPC: G01B9/02
CPC classification number: G01B9/02076 , G01B9/02068 , G01J3/02 , G01J3/0202 , G01J3/0256 , G01J3/06 , G01J3/453 , H01L41/0946 , H01L41/0973
Abstract: The invention relates the movement of at least one movable means of an interferometer relative to the body of the interferometer. The system according to the invention, comprises at least two interferometer actuators, that can be operated individually, so that the at least two actuators are capable of moving the at least one movable means of the interferometer. When activating at least one of the at least two interferometer actuators the at least one movable means of the interferometer is moved with a minimum need for correcting for e.g. tilt. In a preferred configuration the system and the method according to the invention comprises three interferometer actuators that can be operated individually.
Abstract translation: 本发明涉及干涉仪的至少一个可移动装置相对于干涉仪的主体的移动。 根据本发明的系统包括可单独操作的至少两个干涉仪致动器，使得至少两个致动器能够移动干涉仪的至少一个可移动装置。 当激活所述至少两个干涉仪致动器中的至少一个时，干涉仪的至少一个可移动装置以最小的需要被移动， 倾斜。 在优选的配置中，根据本发明的系统和方法包括可以单独操作的三个干涉仪致动器。
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公开(公告)号：US20110312012A1
公开(公告)日：2011-12-22
申请号：US13003943
申请日：2009-07-13
Applicant: Mette Elena Skinderso , Helle Frobøse Sørensen , Søren Kjærulff
Inventor： Mette Elena Skinderso , Helle Frobøse Sørensen , Søren Kjærulff
IPC: C12Q1/02
CPC classification number: G01N33/582 , C09B15/00 , C09B57/00 , C09B57/02 , G01N21/6428 , G01N33/502 , G01N33/583 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2510/00
Abstract: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).
Abstract translation: 本发明提供用于分析细胞的简单，快速的方法和程序，在此对细胞进行定量和定性评估，例如活力。 本发明涉及各种任选取代的报告化合物在完整（例如，活的）细胞中与在非完整（例如死亡，应激和凋亡）细胞中比较高的浓度存在的硫醇类物质反应时特别可检测的用途） 。 本发明还涉及各种任选取代的报告化合物在与完整和/或未完整细胞中存在的物质反应时特别可检测的用途。 此外，本发明涉及与使用各种任选取代的报告化合物的测量技术和/或仪器的用途。 本发明还涉及用于分析细胞的方法中使用的组合物，例如包含N-（7-二甲基氨基-4-甲基-3-香豆素基） - 马来酰亚胺（DACM）的组合物。
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18.发明授权Determination of chemical or physical properties of sample or component of a sample 有权样品或样品组分的化学或物理性质的测定公开(公告)号：US08010299B2
公开(公告)日：2011-08-30
申请号：US12094006
申请日：2006-11-16
Applicant: Börkur Arnvidarson
Inventor： Börkur Arnvidarson
IPC: G06F19/00
CPC classification number: G01J3/45
Abstract: The present invention offers an alternative strategy for the correlation of interference information to chemical and/or physical properties of a sample. This strategy can be implemented in a method and a system, which offer substantial technical and commercial advantages over state of the art techniques based on interference spectroscopy. The method comprises the steps of: a. obtaining an interferogram and/or at least one interferogram element corresponding to a modulation of electromagnetic signal emitted from, transmitted onto or through, or having interacted with at least a part of the sample, b. performing i. at least one transformation of the interferogram and/or a segment of the interferogram and/or an interferogram element with at least one function, ii. optionally repeating i) for another segment of the interferogram and/or interferogram element, wherein the transformation does not comprise a Fourier Transformation if i) is conducted only once, thereby obtaining at least one score, c. correlating said at least one score to the at least one chemical or physical property.
Abstract translation: 本发明提供了用于将干扰信息与样品的化学和/或物理性质相关的替代策略。 该策略可以在与基于干涉光谱技术的现有技术相比提供实质的技术和商业优势的方法和系统中实现。 该方法包括以下步骤：a。 b）获得干涉图和/或至少一个干涉图元素，所述干涉图元素对应于从至少部分样品b发射的或经过或已经与样品的至少一部分相互作用的电磁信号的调制。 表演我 干涉图和/或具有至少一个功能的干涉图和/或干涉图元素的段的至少一次变换，ii。 可选地重复i）干涉图和/或干涉图元素的另一段，其中如果i）仅进行一次，则转换不包括傅立叶变换，从而获得至少一个分数c。 将所述至少一个得分与所述至少一种化学或物理性质相关联。
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19.发明授权System for regulating the handling of milk during the milking process and a method for regulating said milking process 有权用于在挤奶过程中调节牛奶处理的系统和调节所述挤奶过程的方法公开(公告)号：US07155345B1
公开(公告)日：2006-12-26
申请号：US09830558
申请日：1999-11-05
Applicant: Borkur Arnvidarson
Inventor： Borkur Arnvidarson
CPC classification number: A01J5/0135 , A01J5/0132
Abstract: The present invention concerns a system and a method for regulating the handling of milk during the milking process in order to separate mastitis infected milk from milk for human consumption and apt to be applied in an automated milking process.
Abstract translation: 本发明涉及一种用于在挤奶过程中调节牛奶处理的系统和方法，以便将乳腺炎感染的牛奶与牛奶分离以供人消费，并且易于在自动挤奶过程中应用。
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公开(公告)号：US20050225766A1
公开(公告)日：2005-10-13
申请号：US11130717
申请日：2005-05-17
Applicant: Frans Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Jeppesen
Inventor： Frans Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Jeppesen
IPC: G01N33/483 , C12M1/34 , C12Q1/00 , C12Q1/06 , G01N20060101 , G01N15/00 , G01N15/02 , G01N15/06 , G01N15/14 , G01N21/00 , G01N21/49 , G01N21/59 , G01N21/64 , G01N21/65 , G01N24/00 , G01N24/08 , G01N27/12 , G01N33/04 , G01N33/48 , G01N33/487 , G06M11/00
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
Abstract translation: 本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的来自样品的曝光区域电磁信号可以从该区域传播到外部，并将其暴露于诸如CCD元件的主动检测元件阵列上，空间 在从暴露期间通过检测元件阵列检测到的强度的处理条件下，可以通过各个有源检测元件检测作为强度的表示作为强度的表示， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。 液体样品的体积大小足够大以允许评估数量和质量参数以满足基于基本上一次暴露的评估的统计质量的预定要求。
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