公开(公告)号：US11414679B2

公开(公告)日：2022-08-16

申请号：US16466683

申请日：2017-12-07

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC分类号： C12N15/86 ,  C07K14/005 ,  A61K39/21 ,  A61K39/12 ,  A61P31/18 ,  A61P31/14 ,  A61K39/00

摘要： The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US20220235095A1

公开(公告)日：2022-07-28

申请号：US17615254

申请日：2020-06-03

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Carine Berthe Ghislaine DE KESEL ,  Chad Austin FARRENBURG ,  Jeri Kay SANDVICK ,  Jeb Yeatts VANDENBURG

IPC分类号： C07J63/00

摘要： Saponin extracts containing at least 88% QS-21 main peak and >3% to 10% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.

公开(公告)号：US20220221455A1

公开(公告)日：2022-07-14

申请号：US17604008

申请日：2020-04-16

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Nathalie NORAIS ,  Silvia ROSSI PACCANI ,  Simona RONDINI

IPC分类号： G01N33/569

摘要： The present invention relates to the field of antigen binding proteins and the use of such antigen binding proteins in an assay. More particularly, it relates to antigen binding proteins which bind to an epitope of Protein E and antigen binding proteins which bind to an epitope of PilA. The present invention also relates to assays (particularly in vitro assays) for assessing binding to Protein E and/or PilA and the potency of vaccines containing Protein E and/or PilA. In particular the invention relates to in vitro relative potency assays used in the release of a vaccine to the public.

公开(公告)号：US20220204566A1

公开(公告)日：2022-06-30

申请号：US17565796

申请日：2021-12-30

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra Franz VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC分类号： C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  C07K14/75 ,  A61K39/12 ,  C12N15/861 ,  A61K39/155 ,  A61K39/21 ,  C12N7/00

摘要： There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US20220184158A1

公开(公告)日：2022-06-16

申请号：US17416642

申请日：2019-12-20

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Jean-Francois TOUSSAINT ,  Vanesa BOL

IPC分类号： A61K35/768 ,  A61K39/12 ,  A61K38/17 ,  A61P35/00 ,  C12N7/00

摘要： There is provided inter alia a method of treating cancer in a mammal, said method comprising the steps of: (i) administering to the mammal a first composition comprising an antigen or comprising a nucleic acid encoding an antigen and (ii) administering to the mammal a second composition comprising an oncolytic virus wherein the oncolytic virus comprises a nucleic acid encoding the antigen.

公开(公告)号：US20220119455A1

公开(公告)日：2022-04-21

申请号：US17360320

申请日：2021-06-28

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Michael FRANTI ,  Anders LILJA ,  Rebecca LOOMIS ,  Peter W. MASON

IPC分类号： C07K14/005 ,  A61K39/12 ,  C12N15/86

摘要： This disclosure provides platforms for delivery of herpes virus proteins to cells, particularly proteins that form complexes in vivo. In some embodiments these proteins and the complexes they form elicit potent neutralizing antibodies. Thus, presentation of herpes virus proteins using the disclosed platforms permits the generation of broad and potent immune responses useful for vaccine development.

公开(公告)号：US11278613B2

公开(公告)日：2022-03-22

申请号：US16630951

申请日：2018-07-16

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Kathryn Hashey ,  Padma Malyala ,  Marcelo Samsa ,  Olga Slack ,  Dong Yu ,  Alan Stokes ,  Rashmi Jalah

IPC分类号： A61K39/205 ,  A61K9/127 ,  A61K39/00

摘要： Nucleic acid based vaccine constructs encoding Lyssaviral antigens are useful in preventing and treating diseases. Self-amplifying RNA molecules encoding Lyssaviral antigens provide potent and long-lasting immunity.

公开(公告)号：US11266733B2

公开(公告)日：2022-03-08

申请号：US16650790

申请日：2018-09-25

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Wivine Burny ,  Cindy Castado ,  Sandra Giannini ,  Julien Thierry Massaux

IPC分类号： C12N15/86 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K39/385

摘要： Nucleotide constructs encoding antigenic peptides or polypeptides derived from multiple Human Papilloma Virus (HPV) early proteins, immunogenic compositions comprising such constructs and a pharmaceutically acceptable carrier, and uses thereof.

公开(公告)号：US20220002355A1

公开(公告)日：2022-01-06

申请号：US17346362

申请日：2021-06-14

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Matthew BOTTOMLEY ,  Vega MASIGNANI

IPC分类号： C07K14/22 ,  A61K39/095

摘要： The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.

公开(公告)号：US11135300B2

公开(公告)日：2021-10-05

申请号：US14760916

申请日：2014-01-13

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Roberto Adamo ,  Francesco Berti ,  Qi-Ying Hu

IPC分类号： A61K47/55 ,  C08B37/00 ,  A61K47/64 ,  A61K47/54 ,  A61K39/09

摘要： This disclosure provides novel saccharide derivatives, conjugates, and methods for making the derivatives and conjugates.