公开(公告)号：US12076392B2

公开(公告)日：2024-09-03

申请号：US17698205

申请日：2022-03-18

申请人： Intervet Inc.

发明人： Ian Tarpey

IPC分类号： C12N7/00 ,  A61K39/21 ,  A61P31/14 ,  C12N15/11 ,  C12N15/33 ,  C12N15/48 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/21 ,  A61P31/14 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2740/13034 ,  C12N2740/13071 ,  C12N2770/36143

摘要： The present invention provides a vaccine for feline leukemia virus and methods of making and using the vaccine alone, or in combinations with other protective agents.

公开(公告)号：US20240269268A1

公开(公告)日：2024-08-15

申请号：US18569589

申请日：2022-06-17

申请人： Elixirgen Therapeutics, Inc.

发明人： Minoru S.H. KO

IPC分类号： A61K39/295 ,  A61K39/00 ,  A61K39/145 ,  A61K39/215 ,  A61P31/14 ,  C12N15/86

CPC分类号： A61K39/295 ,  A61K39/145 ,  A61K39/215 ,  A61P31/14 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55583 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/02 ,  C12N2760/14122 ,  C12N2760/14134 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2770/36122 ,  C12N2770/36143

摘要： The present disclosure relates to mRNA, self-replicating RNA, and temperature-sensitive, self-replicating RNA encoding a coronavirus nucleocapsid protein or an influenza virus nucleocapsid protein in operable combination with a mammalian signal peptide. The present disclosure relates to mRNA, self-replicating RNA, and temperature-sensitive, self-replicating RNA encoding other viral nucleocapsid protein(s) in operable combination with a mammalian signal peptide. The RNA constructs are suitable for active immunization against a virus in a mammalian subject, such as a human subject.

公开(公告)号：US12060393B2

公开(公告)日：2024-08-13

申请号：US16116203

申请日：2018-08-29

申请人： The Board of Trustees of the University of Illinois

发明人： Ramaswamy Kalyanasundaram

IPC分类号： C07K14/435 ,  A61K39/00 ,  C12N9/08 ,  G01N33/569

CPC分类号： C07K14/4354 ,  A61K39/0003 ,  C12N9/0065 ,  G01N33/56966 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/70 ,  C07K2319/00 ,  C07K2319/40 ,  G01N2333/4353 ,  G01N2469/10 ,  G01N2469/20 ,  Y02A50/30

摘要： The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.

公开(公告)号：US20240252627A1

公开(公告)日：2024-08-01

申请号：US18629427

申请日：2024-04-08

申请人： Longeveron Inc.

发明人： Joshua M. HARE ,  Ana Marie LANDIN

IPC分类号： A61K39/39 ,  A61K35/28 ,  A61K38/00 ,  A61K39/00 ,  A61K39/145 ,  A61P31/16

CPC分类号： A61K39/39 ,  A61K35/28 ,  A61K39/145 ,  A61P31/16 ,  A61K38/00 ,  A61K2039/515 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/555 ,  A61K2039/55588 ,  A61K2039/70

摘要： The present invention provides a method of enhancing an immune response to a vaccine by administering a vaccine and a population of isolated allogeneic human mesenchymal stem cells. The present invention also provides kits comprising a vaccine in a first container and a population of isolated allogeneic human mesenchymal stem cells in a second container.

公开(公告)号：US20240239844A1

公开(公告)日：2024-07-18

申请号：US17922307

申请日：2021-04-30

申请人： LA JOLLA INSTITUTE FOR IMMUNOLOGY

发明人： Erica Ollmann SAPHIRE ,  Haoyng LI

IPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/215 ,  C12N15/86 ,  A61K2039/70 ,  C12N2710/14043 ,  C12N2740/15043 ,  C12N2760/14122 ,  C12N2760/14134 ,  C12N2760/20243 ,  C12N2770/20022 ,  C12N2770/20034

摘要： Compositions and methods are disclosed for treating and/or preventing viral infections and related pathologies (e.g., Coronavirus and Ebola virus infections and related pathologies). Composition includes those with modified viral glycoproteins, wherein one or more portions of the modified viral glycoproteins are modified to comprise an antigen. Variously, the antigen can include a Coronavirus antigen or an Ebola virus antigen.

公开(公告)号：US20240226264A1

公开(公告)日：2024-07-11

申请号：US18396787

申请日：2023-12-27

申请人： Boehringer Ingelheim Vetmedica GmbH ,  lowa State University Research Foundation, Inc.

发明人： Arun IYER ,  Luis Alejandro Hernandez ,  Abby Patterson ,  Bailey Arruda ,  Luis Gabriel Gimenez-Lirola ,  Dave Michael Anstrom ,  Eric M. Vaughn ,  Pablo E Pineyro Pineiro ,  Troy James Kaiser ,  Joseph Ralph Hermann

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/23 ,  A61P31/20 ,  A61P37/04

CPC分类号： A61K39/12 ,  A61K39/23 ,  A61P31/20 ,  A61P37/04 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2750/10034 ,  C12N2750/10071 ,  C12N2750/14034

摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.

公开(公告)号：US20240216502A1

公开(公告)日：2024-07-04

申请号：US18504962

申请日：2023-11-08

申请人： Hugh MASON ,  Andrew DIAMOS ,  Mary PARDHE ,  Brandon FAVRE

发明人： Hugh MASON ,  Andrew DIAMOS ,  Mary PARDHE ,  Brandon FAVRE

IPC分类号： A61K39/29 ,  A61K39/12 ,  A61K39/145 ,  A61P31/20 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/292 ,  A61K39/12 ,  A61K39/145 ,  A61P31/20 ,  C12N7/00 ,  A61K2039/505 ,  A61K2039/5258 ,  A61K2039/575 ,  A61K2039/6056 ,  A61K2039/70 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20071 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2730/10171 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134 ,  C12N2770/24171

摘要： The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.

公开(公告)号：US20240207401A1

公开(公告)日：2024-06-27

申请号：US17911257

申请日：2021-03-19

申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED

发明人： Xiao-Ning Xu ,  Hantao Lou ,  Jia Guo

IPC分类号： A61K39/42 ,  A61K39/00 ,  A61P31/14 ,  C07K16/10 ,  G01N33/569 ,  G01N33/68

CPC分类号： A61K39/42 ,  A61P31/14 ,  C07K16/1003 ,  G01N33/56983 ,  G01N33/6854 ,  A61K2039/505 ,  A61K2039/70 ,  G01N2333/165

摘要： An antibody or antigen-binding fragment thereof is described which binds to the spike protein S2 domain of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV) and/or severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). The antibodies can be used in the diagnosis and treatment of coronavirus infection. The invention extends to compositions comprising the antibodies, including pharmaceutical compositions, diagnostic compositions, and kits. The invention also extends to methods of making and using the antibodies, for example in the diagnosis and therapy of coronavirus infections.

公开(公告)号：US12018054B2

公开(公告)日：2024-06-25

申请号：US16497178

申请日：2018-04-13

申请人： Valneva Austria GmbH

发明人： Urban Lundberg ,  Andreas Meinke ,  Abhijeet Nayak ,  Wolfgang Schüler

IPC分类号： A61K39/02 ,  A61K39/39 ,  A61P31/04 ,  C07K14/20 ,  A61K39/00

CPC分类号： C07K14/20 ,  A61K39/0225 ,  A61K39/39 ,  A61P31/04 ,  A61K2039/55505 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/02 ,  C07K2319/90

摘要： The present invention relates to an immunogenic polypeptide, a nucleic acid encoding the same, a pharmaceutical composition comprising the same and the immunogenic polypeptide, nucleic acid or pharmaceutical composition for use as a medicament, particularly a vaccine, or for use in a method of treating or preventing a Borrelia infection.

公开(公告)号：US12012438B2

公开(公告)日：2024-06-18

申请号：US17346452

申请日：2021-06-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Jeffrey Schlom ,  Claudia M. Palena

IPC分类号： C07K14/47 ,  A61K9/127 ,  A61K38/17 ,  A61K38/19 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/86

CPC分类号： C07K14/4702 ,  A61K9/127 ,  A61K38/1709 ,  A61K38/193 ,  A61K39/0011 ,  A61K39/001152 ,  A61K39/00117 ,  A61K39/001182 ,  A61K45/06 ,  A61P35/00 ,  C12N15/86 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N2710/10043 ,  Y02A50/30

摘要： The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use.