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    Antibacterial agents and methods of use thereof
    12.
    发明授权
    Antibacterial agents and methods of use thereof 有权
    抗菌剂及其使用方法

    公开(公告)号：US08618327B2

    公开(公告)日：2013-12-31

    申请号：US13543572

    申请日：2012-07-06

    申请人： Helen E. Blackwell ,  Matthew D. Bowman ,  Jennifer C. O'Neill ,  Joseph R. Stringer

    发明人： Helen E. Blackwell ,  Matthew D. Bowman ,  Jennifer C. O'Neill ,  Joseph R. Stringer

    IPC分类号： C07C211/00 ,  A61K33/02

    CPC分类号： A61K31/122 ,  A61K31/4412 ,  C07C45/74 ,  C07C49/813 ,  C07C49/835 ,  C07C49/84 ,  C07D213/85 ,  C07D239/26 ,  C07D239/42 ,  C12Q1/18

    摘要： The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use. For example, the present invention provides chalcone and cyanopyridine compounds, and derivatives thereof, exhibiting high antibacterial activities having multiple electron withdrawing group substituents, such as halogens and fluorinated alkyl groups, and optionally having hydroxyl and/or alkoxyl groups substituents.

    摘要翻译： 本发明一般涉及提供抗菌治疗剂和制剂的化合物，以及使用和制备抗菌化合物的相关方法。 本发明的抗菌化合物包括查耳酮，烷基嘧啶，氨基嘧啶和氰基吡啶化合物及其在广泛使用中表现出与常规抗菌化合物类似或更少的最小抑制浓度（MIC）的衍生物。 例如，本发明提供查耳酮和氰基吡啶化合物及其衍生物，其表现出具有多个吸电子基团取代基的高抗菌活性，例如卤素和氟化烷基，并且任选具有羟基和/或烷氧基取代基。

    Method for preparing 3-trifluoromethyl chalcones
    13.
    发明授权
    Method for preparing 3-trifluoromethyl chalcones 有权

    公开(公告)号：US08546618B2

    公开(公告)日：2013-10-01

    申请号：US12933493

    申请日：2009-04-08

    申请人： Gary David Annis

    发明人： Gary David Annis

    IPC分类号： C07C49/80 ,  C07C45/74 ,  C07C45/68

    CPC分类号： C07D261/04 ,  C07C17/35 ,  C07C25/13 ,  C07C45/455 ,  C07C45/70 ,  C07C49/80 ,  C07C49/813 ,  C07C67/343 ,  C07C205/45 ,  C07C209/74 ,  C07C231/12 ,  C07C231/14 ,  C07C235/84 ,  C07D213/40 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C69/94 ,  C07C69/76 ,  C07C211/56

    摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

    ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF
    16.
    发明申请
    ANTIBACTERIAL AGENTS AND METHODS OF USE THEREOF 有权
    抗菌剂及其使用方法

    公开(公告)号：US20100261763A1

    公开(公告)日：2010-10-14

    申请号：US12815250

    申请日：2010-06-14

    申请人： Helen E. BLACKWELL ,  Matthew D. BOWMAN ,  Jennifer C. O'NEILL ,  Joseph R. STRINGER

    发明人： Helen E. BLACKWELL ,  Matthew D. BOWMAN ,  Jennifer C. O'NEILL ,  Joseph R. STRINGER

    IPC分类号： A61K31/44 ,  C07C49/794 ,  A61K31/12 ,  C07D213/84 ,  A61P31/04

    CPC分类号： A61K31/122 ,  A61K31/4412 ,  C07C45/74 ,  C07C49/813 ,  C07C49/835 ,  C07C49/84 ,  C07D213/85 ,  C07D239/26 ,  C07D239/42 ,  C12Q1/18

    摘要： The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use. For example, the present invention provides chalcone and cyanopyridine compounds, and derivatives thereof, exhibiting high antibacterial activities having multiple electron withdrawing group substituents, such as halogens and fluorinated alky groups, and optionally having hydroxyl and/or alkoxyl groups substituents.

    摘要翻译： 本发明一般涉及提供抗菌治疗剂和制剂的化合物，以及使用和制备抗菌化合物的相关方法。 本发明的抗菌化合物包括查耳酮，烷基嘧啶，氨基嘧啶和氰基吡啶化合物及其在广泛使用中表现出与常规抗菌化合物类似或更少的最小抑制浓度（MIC）的衍生物。 例如，本发明提供查耳酮和氰基吡啶化合物及其衍生物，表现出具有多个吸电子基团取代基的高抗菌活性，例如卤素和氟化烷基，以及任选具有羟基和/或烷氧基取代基。

    Acetylene-terminated hyperbranched poly(arylene-ether-ketone-imides)
    18.
    发明授权
    Acetylene-terminated hyperbranched poly(arylene-ether-ketone-imides) 失效
    乙炔封端的超支化聚（亚芳基醚 - 酮 - 酰亚胺）

    公开(公告)号：US07678873B1

    公开(公告)日：2010-03-16

    申请号：US12079086

    申请日：2008-02-11

    申请人： Loon-Seng Tan ,  David H. Wang

    发明人： Loon-Seng Tan ,  David H. Wang

    IPC分类号： C08G8/02

    CPC分类号： C08G73/1046 ,  C07C49/813 ,  C08G83/005

    摘要： Novel ether-ketone-imide hyperbranched polymers with thermally reactive ethynyl endgroups were prepared from the corresponding AB2 monomer and the respective benzophenone-based endcapping agents in one-pot fashion. The resulting polymer has repeating units of the formula: where the chain-end groups, Ar is a benzophenone with an ortho, a meta- or a para-ethynyl substituent.

    摘要翻译： 具有热反应性乙炔基端基的新型醚 - 酮 - 酰亚胺超支化聚合物是以相应的AB2单体和相应的二苯甲酮为基础的一次性封端剂制成的。 所得聚合物具有下式的重复单元：其中链端基Ar是具有邻位，间或对乙炔基取代基的二苯甲酮。

    Spirobifluorene derivatives, their preparation and uses thereof
    19.
    发明授权
    Spirobifluorene derivatives, their preparation and uses thereof 有权
    螺二芴衍生物，其制备和用途

    公开(公告)号：US07557249B2

    公开(公告)日：2009-07-07

    申请号：US10523101

    申请日：2003-07-31

    申请人： Liliana Bagala' Rampazzo ,  Giulia Fioravanti ,  Leonardo Mattiello

    发明人： Liliana Bagala' Rampazzo ,  Giulia Fioravanti ,  Leonardo Mattiello

    IPC分类号： C07C49/00 ,  H01L51/54

    CPC分类号： C07D333/22 ,  C07C45/46 ,  C07C49/792 ,  C07C49/813 ,  C07C49/84 ,  C07D307/46 ,  C09K11/06 ,  C09K2211/1003 ,  C09K2211/1011 ,  C09K2211/1425 ,  C25B3/04 ,  H01L51/0058 ,  H01L51/5012 ,  Y10S428/917

    摘要： The invention concerns Spirobifluorene derivatives having the general formula (II) and the corresponding, radical anions that can be represented via the general formula (II): in which K, L, M and N, the same or different from each other, are independently: H or A-C═O, with the proviso that it is never K=L=M=N=H, wherein A is an aromatic group, possibly substituted with at least an R′ group selected in the group of the substituents commonly used in organic chemistry and/or at least one R group where R=aliphatic radical. The invention also concerns the method for preparing said derivatives and radical anions. Said compounds are applied in the field of components for molecular electronics, in particular systems for electroluminescence, molecular-based computational systems, OLEDs, molecular switching components, components for non-linear optics, field-effect transistors and semiconductors with negative differential resistance.

    摘要翻译： 本发明涉及具有通式（II）和可以通过通式（II）表示的相应的自由基阴离子的螺二芴衍生物：其中彼此相同或不同的K，L，M和N独立地为 ：H或ACO，条件是从不K = L = M = N = H，其中A是芳族基团，可能被至少一个选自在有机化学中通常使用的取代基中选择的R'基团取代 和/或至少一个R基团，其中R =脂族基团。 本发明还涉及制备所述衍生物和自由基阴离子的方法。 所述化合物应用于分子电子学的组件领域，特别是用于电致发光，基于分子的计算系统，OLED，分子开关组件，非线性光学元件，场效应晶体管和具有负微分电阻的半导体的系统领域。