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11.发明申请公开(公告)号：US20170342448A1
公开(公告)日：2017-11-30
申请号：US15314227
申请日：2015-05-28
Applicant: Reliance Industries Limited
Inventor： Gautam Das , Santanu Dasgupta , Venkatesh Prasad , Vinodhkumar Vijayakumar , Pranali Deore , Kannadasan Kaliyamoorthy , Sujata Kumari
CPC classification number: C12P7/6463 , C11C3/00 , C12N1/12 , C12N9/1007 , C12N9/1029 , C12N15/102 , C12N15/65 , C12N15/74 , C12P7/00 , C12R1/01 , C12Y201/01037 , C12Y203/01031
Abstract: The present disclosure relates to a method for increasing lipid content in microorganisms. The method comprises decreasing the expression of molecules involved in the protein synthesis to decrease protein synthesis and thereby increase lipid synthesis in the microorganisms. The present disclosure also provides a modified microorganism having increased lipid content.
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公开(公告)号：US20160272977A1
公开(公告)日：2016-09-22
申请号：US15034092
申请日：2014-11-10
Applicant: NEW ENGLAND BIOLABS INC.
Inventor： Sriharsa Pradhan , Pierre O. Esteve , Guoqiang Zhang
IPC: C12N15/113 , A61K31/7105
CPC classification number: C12N15/1137 , A61K31/7105 , C12N2310/11 , C12N2310/141 , C12N2310/151 , C12N2320/30 , C12Y201/01037
Abstract: RNA molecules inhibiting a DNMT and methods and compositions incorporating or generating the RNA molecules are described.
Abstract translation: 描述了抑制DNMT的RNA分子以及掺入或产生RNA分子的方法和组合物。
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公开(公告)号：US20140171492A1
公开(公告)日：2014-06-19
申请号：US14111971
申请日：2012-04-13
Applicant: Annalisa Di Ruscio , Alexander K. Ebralidze , Daniel G. Tenen , Giuseppe Leone
Inventor： Annalisa Di Ruscio , Alexander K. Ebralidze , Daniel G. Tenen , Giuseppe Leone
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N15/1137 , C12N15/635 , C12N2310/113 , C12N2310/13 , C12N2310/333 , C12N2310/334 , C12N2320/31 , C12Y201/01037 , C12N2310/14 , C12N2310/531
Abstract: The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.
Abstract translation: 本发明涉及作为单链寡核苷酸的嵌合RNA寡核苷酸。 这些化合物能够靶向特定基因并降低DNA甲基转移酶活性。 因此，这些化合物特别可用于治疗与异常DNA甲基转移酶活性相关的疾病，例如癌症或遗传性疾病。
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公开(公告)号：US11819554B2
公开(公告)日：2023-11-21
申请号：US15760765
申请日：2016-09-16
Applicant: University of Massachusetts
Inventor： Michael R. Green , Minggang Fang , Walter Kowtoniuk
IPC: A61K31/711 , A61K35/30 , A61K38/45 , A61K38/53 , A61K39/395 , A61K48/00 , A61K31/5377 , A61K31/549 , A61K31/706 , A61K31/713 , C12Q1/6883 , C12N15/113 , A61K31/7088 , A61K31/404 , A61K31/546 , A61K31/167 , A61K31/497 , A61K31/506 , A61K31/437 , A61K31/4406 , A61K31/522 , A61K31/496 , A61P25/14 , A61P15/02 , A61K31/7105
CPC classification number: A61K48/005 , A61K31/167 , A61K31/404 , A61K31/437 , A61K31/4406 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5377 , A61K31/546 , A61K31/549 , A61K31/706 , A61K31/7088 , A61K31/711 , A61K31/713 , A61K31/7105 , A61K35/30 , A61K38/45 , A61K38/53 , A61K39/3955 , A61K48/0016 , A61P15/02 , A61P25/14 , C12N15/113 , C12Q1/6883 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12Q2600/154 , C12Q2600/158 , C12Y201/01037 , C12Y201/01043 , C12Y603/02019
Abstract: The disclosure relates to methods and compositions for reactivating a silenced FMR1 gene. In some aspects, methods described by the disclosure are useful for treating a FMR1-inactivation-associated disorder (e.g., fragile X syndrome).
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公开(公告)号：US11814623B2
公开(公告)日：2023-11-14
申请号：US16231129
申请日：2018-12-21
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: C12N15/113 , A61K35/28 , A61K31/19 , A61P17/02 , A61K31/7052
CPC classification number: C12N15/1137 , A61K31/19 , A61K31/7052 , A61K35/28 , A61P17/02 , C12Y106/03001 , C12Y201/01037 , C12N2310/11 , C12N2310/122 , C12N2310/14 , C12N2310/141 , C12N2320/31
Abstract: Methods of treating wounds in a subject using one or both of a DNA methyltransferase 1 (DNMT1) inhibitor or a nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) inhibitor, and compositions for use in these methods.
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Patent Agency Ranking
公开(公告)号：US20230183793A1
公开(公告)日：2023-06-15
申请号：US17999260
申请日：2021-05-19
Inventor： Rahul Kohli , Tong Wang , Emily Schutsky
IPC: C12Q1/6858 , C12N9/10
CPC classification number: C12Q1/6858 , C12Y201/01037 , C12N9/1007 , C12Q1/6806
Abstract: Compositions and methods for carboxymethylation of cytosine containing DNA and applications thereof for direct sequencing of 5mC are disclosed.
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公开(公告)号：US20190233805A1
公开(公告)日：2019-08-01
申请号：US16151895
申请日：2018-10-04
Applicant: The Regents of the University of California
Inventor： David J Segal , Henriette O'Geen , Joel P. Mackay , Peggy J. Farnham
CPC classification number: C12N9/22 , C07K14/4702 , C07K2319/09 , C07K2319/43 , C07K2319/81 , C12N9/1007 , C12Y201/01037 , C12Y201/01043
Abstract: Provided herein are fusion proteins comprising a catalytically inactive Cas9 domain and an effector domain. The fusion proteins of the present invention can be used to, for example, produce epigenetic modifications at target chromatin sites. Nucleic acids and expression vectors encoding the fusion proteins, as well as cells comprising the fusion proteins, are also provided herein.
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18.发明授权公开(公告)号：US10059968B2
公开(公告)日：2018-08-28
申请号：US15314227
申请日：2015-05-28
Applicant: Reliance Industries Limited
Inventor： Gautam Das , Santanu Dasgupta , Venkatesh Prasad , Vinodhkumar Vijayakumar , Pranali Deore , Kannadasan Kaliyamoorthy , Sujata Kumari
CPC classification number: C12P7/6463 , C11C3/00 , C12N1/12 , C12N9/1007 , C12N9/1029 , C12N15/102 , C12N15/65 , C12N15/74 , C12P7/00 , C12R1/01 , C12Y201/01037 , C12Y203/01031
Abstract: The present disclosure relates to a method for increasing lipid content in microorganisms. The method comprises decreasing the expression of molecules involved in the protein synthesis to decrease protein synthesis and thereby increase lipid synthesis in the microorganisms. The present disclosure also provides a modified microorganism having increased lipid content.
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公开(公告)号：US20180239878A1
公开(公告)日：2018-08-23
申请号：US15895057
申请日：2018-02-13
Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Inventor： Vern L. Schramm , Quan Du , Zhen Wang
CPC classification number: G16C20/50 , C12N9/1007 , C12Q1/48 , C12Y201/01037 , G16C20/10
Abstract: Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state.
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公开(公告)号：US20170268008A1
公开(公告)日：2017-09-21
申请号：US15529399
申请日：2015-11-24
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ahmed Khalil , Sanford Markowitz
IPC: C12N15/113 , C12Q1/68
CPC classification number: C12N15/1137 , A61K31/7088 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N2310/10 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/20 , C12N2320/11 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178 , C12Y201/01037 , G01N33/50 , G01N33/574
Abstract: A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in the cancer cells of the subject. Embodiments described herein relate to RNAs (e.g., IncRNAs) associated with DNA methyltransferase 1 (DNMTI-associated RNA) in human cancer cells, methods and compositions of modulating the levels of DNMTI-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in cancer cells of the subject to treat cancer cells or a subject in need thereof, and/or methods of measuring the expression profile of DNMT1 associated RNA to determine whether the subject has cancer or an increased risk of cancer and/or the efficacy of a therapeutic regimen agent.
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