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公开(公告)号：US20230374549A1
公开(公告)日：2023-11-23
申请号：US18028975
申请日：2021-09-29
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Lauren Marie BEECH , Jesse Jerome SMITH , Rahul KARNIK , Kendrick Alan GOSS , Adam Walter SCHEIDEGGER , Jodi Michelle KENNEDY , Jeremiah Dale FARELLI , Houda BELAGHZAL , Laura Anh NGUYEN , Charles W. O'DONNELL
IPC: C12N15/90 , C12N9/22 , C12N15/11 , C12N9/10 , C12N9/80 , A61P37/06 , A61K35/12 , A61K38/46 , A61K31/7088 , C07K14/47
CPC classification number: C12N15/907 , C12N9/22 , C12N15/11 , C12N9/1007 , C12Y201/01043 , C12N9/80 , C12Y305/01098 , A61P37/06 , A61K35/12 , A61K38/465 , A61K31/7088 , C07K14/4703 , C12Y201/01037 , C12Y201/01072 , C12N2310/20 , A61K2035/122 , C07K2319/00
Abstract: The present disclosure relates to site-specific disrupting agents for modulating, e.g., decreasing, expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises pro-inflammatory genes, e.g., CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the method comprises using a first site-specific disrupting agent that targets a first anchor sequence and a second site-specific disrupting agents that disrupts a second anchor sequence.
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12.发明授权公开(公告)号：US09890385B2
公开(公告)日：2018-02-13
申请号：US15395184
申请日：2016-12-30
Applicant: Battelle Energy Alliance, LLC
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
IPC: C12N15/74 , C07K14/195
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
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13.发明授权Type II restriction modification system methylation subunit of Alicyclobacillus acidocaldarius 有权酸性脂环酸杆菌的II型限制性修饰系统甲基化亚基公开(公告)号：US09567595B2
公开(公告)日：2017-02-14
申请号：US14707231
申请日：2015-05-08
Applicant: BATTELLE ENERGY ALLIANCE, LLC
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 进一步提供的是使用分离和/或纯化的多肽和/或酸碱热杆菌的核酸序列调节或改变细胞内部或外部的重组的方法。
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14.发明申请POLYNUCLEOTIDES ENCODING BREX SYSTEM POLYPEPTIDES AND METHODS OF USING SAME 审中-公开编织BREX系统聚合物的多核苷酸及其使用方法公开(公告)号：US20160281053A1
公开(公告)日：2016-09-29
申请号：US15030876
申请日：2014-10-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Rotem SOREK , Hila SBERRO , Tamara GOLDFARB
IPC: C12N1/20 , C07K14/195 , C12N9/10 , C12N9/48 , A23C9/123 , C12N9/12 , C12N9/02 , C07K14/245 , C07K14/32 , C12N15/52 , C12N9/16 , C12N9/14
CPC classification number: C12N1/20 , A23C9/1234 , A23C2220/202 , C07K14/195 , C07K14/245 , C07K14/32 , C12N9/0051 , C12N9/1007 , C12N9/12 , C12N9/14 , C12N9/16 , C12N9/48 , C12N15/52 , C12Y108/04008 , C12Y201/01072 , C12Y207/11001 , C12Y301/03001 , C12Y304/00 , C12Y306/04012 , C12Y306/04013
Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
Abstract translation: 提供编码BREX系统的分离的多核苷酸。 因此，提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ和pglX，pglXI，brxP，brxHI，brxHII，brxL，brxD，brxA，brxB，brxD，brxA，brxB，brxF中的至少一种的BREX系统的核酸序列 和brxE，条件是所述BREX系统不包含pglW，并且其中所述BREX系统赋予对重组表达的细菌的噬菌体抗性; 还提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ，pglX，pglW和至少一种brxD和brxHI的BREX系统的核酸序列，并且其中所述BREX系统将重组的噬菌体抗性赋予细菌 表达相同。 还提供了赋予细菌噬菌体抗性或赋予细菌对噬菌体易感性的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US09428755B2
公开(公告)日：2016-08-30
申请号：US14592208
申请日：2015-01-08
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
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公开(公告)号：US09139628B2
公开(公告)日：2015-09-22
申请号：US12143886
申请日：2008-06-23
Applicant: Michal Minczuk , Monika A. Papworth , Aaron Klug
Inventor： Michal Minczuk , Monika A. Papworth , Aaron Klug
CPC classification number: A61K38/1709 , A61K38/45 , A61K38/46 , C07K14/47 , C07K2319/07 , C07K2319/095 , C07K2319/81 , C12N9/1007 , C12N9/14 , C12Y201/01072 , C12Y306/03014
Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
Abstract translation: 提供了将线粒体蛋白递送至线粒体的方法。 还提供了包含编码与线粒体靶向序列（MTS）和核出口信号（NES）融合的DNA结合多肽的编码序列的核酸构建体，以及编码的蛋白质。 该构建体成功地将DNA结合蛋白递送至线粒体。 基于上述构建体的嵌合甲基化酶被成功地递送至线粒体，导致mtDNA的修饰。
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17.发明申请TYPE II RESTRICTION MODIFICATION SYSTEM METHYLATION SUBUNIT OF ALICYCLOBACILLUS ACIDOCALDARIUS 有权乙型胆碱酯酶II型限制性修饰体系甲基化亚型公开(公告)号：US20150259693A1
公开(公告)日：2015-09-17
申请号：US14707231
申请日：2015-05-08
Applicant: BATTELLE ENERGY ALLIANCE, LLC
Inventor： BRADY D. LEE , DEBORAH T. NEWBY , JEFFREY A. LACEY , DAVID N. THOMPSON , VICKI S. THOMPSON , WILLIAM A. APEL , FRANCISCO F. ROBERTO , DAVID W. REED
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 进一步提供的是使用分离和/或纯化的多肽和/或酸碱热杆菌的核酸序列调节或改变细胞内部或外部的重组的方法。
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公开(公告)号：US20150191736A1
公开(公告)日：2015-07-09
申请号：US14592208
申请日：2015-01-08
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
Abstract translation: 本发明提供编码DNA I型甲基转移酶的分离的多核苷酸及其用于提高外源和内源质粒DNA转化成梭菌宿主的转化效率的用途。
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19.发明申请GENETIC ELEMENTS, PROTEINS, AND ASSOCIATED METHODS INCLUDING APPLICATION OF ADDIITNAL GENETIC INFORMATION TO GRAM (+) THERMOACIDOPHILES 有权遗传元素，蛋白质和相关方法，包括将添加剂基因信息应用于GRAM（+）热保护素公开(公告)号：US20130029400A1
公开(公告)日：2013-01-31
申请号：US13604979
申请日：2012-09-06
Applicant: Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
IPC: C12N15/52 , C12N9/14 , C12N9/00 , C12N9/52 , C12N9/16 , C07K14/195 , C12N9/12 , C12N9/90 , C12N9/02 , C12N9/22 , C12N15/31 , C12N15/63 , C12N9/10
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 进一步提供的是使用分离和/或纯化的多肽和/或酸碱热杆菌的核酸序列调节或改变细胞内部或外部的重组的方法。
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