公开(公告)号：US09829424B2

公开(公告)日：2017-11-28

申请号：US15036416

申请日：2015-08-27

申请人： Chao Yan

发明人： Chao Yan

IPC分类号： G01N15/14 ,  G01N1/40 ,  G01N30/74 ,  G01N30/84

CPC分类号： G01N15/1404 ,  G01N1/4022 ,  G01N15/1459 ,  G01N15/1484 ,  G01N30/74 ,  G01N30/84 ,  G01N2001/4027 ,  G01N2015/1409 ,  G01N2030/8494 ,  G01N21/47

摘要： A sheath flow device for an evaporation light scattering detector comprises an evaporation pipe fastener (110), an evaporation pipe heat insulating component (120), a sheath flow nozzle blocking plate (130), a sheath flow nozzle (140), a sheath flow sleeve (150), a sheath flow outlet piece (170) and a stainless steel spray needle (160). The evaporation pipe fastener, the evaporation pipe heat insulating component, the sheath flow nozzle blocking plate, the sheath flow nozzle, the sheath flow sleeve and the sheath flow outlet piece are concentrically connected orderly from front to back, and all provided with concentric inner holes. Said device is applicable to ELSD sheath flow devices ranging from nanoliter-scale to microliter-scale. On one hand, material particles entering a testing pool are enveloped and aggregated so that the formation of eddy and turbulence can be reduced, the chromatographic peak shape of a sample can be improved and the stability of sample detection can be enhanced; on the other hand, the testing pool can be cleaned so that baseline noise can be reduced and the signal to noise ratio can be increased.

公开(公告)号：US20160290914A1

公开(公告)日：2016-10-06

申请号：US15036416

申请日：2015-08-27

申请人： Chao YAN

发明人： Chao YAN

IPC分类号： G01N15/14 ,  G01N1/40

CPC分类号： G01N15/1404 ,  G01N1/4022 ,  G01N15/1459 ,  G01N15/1484 ,  G01N30/74 ,  G01N30/84 ,  G01N2001/4027 ,  G01N2015/1409 ,  G01N2030/8494 ,  G01N21/47

摘要： A sheath flow device for an evaporation light scattering detector comprises an evaporation pipe fastener (110), an evaporation pipe heat insulating component (120), a sheath flow nozzle blocking plate (130), a sheath flow nozzle (140), a sheath flow sleeve (150), a sheath flow outlet piece (170) and a stainless steel spray needle (160). The evaporation pipe fastener, the evaporation pipe heat insulating component, the sheath flow nozzle blocking plate, the sheath flow nozzle, the sheath flow sleeve and the sheath flow outlet piece are concentrically connected orderly from front to back, and all provided with concentric inner holes. Said device is applicable to ELSD sheath flow devices ranging from nanoliter-scale to microliter-scale. On one hand, material particles entering a testing pool are enveloped and aggregated so that the formation of eddy and turbulence can be reduced, the chromatographic peak shape of a sample can be improved and the stability of sample detection can be enhanced; on the other hand, the testing pool can be cleaned so that baseline noise can be reduced and the signal to noise ratio can be increased.

摘要翻译： 一种用于蒸发光散射检测器的鞘流装置包括蒸发管紧固件（110），蒸发管绝热部件（120），鞘流喷嘴阻挡板（130），鞘流喷嘴（140），鞘流 套管（150），护套流出口件（170）和不锈钢喷针（160）。 蒸发管紧固件，蒸发管绝热部件，护套流动喷嘴阻挡板，护套流动喷嘴，护套流动套筒和护套流出口件从前到后均匀地连接，并且均设有同心的内孔 。 所述装置适用于从纳升级至微升级的ELSD护套流量装置。 一方面，进入测试池的材料颗粒被包裹和聚集，从而可以减少涡流和湍流的形成，可以提高样品的色谱峰形，提高样品检测的稳定性; 另一方面，可以清洁测试池，从而可以降低基线噪声，并且可以提高信噪比。

公开(公告)号：US08920658B2

公开(公告)日：2014-12-30

申请号：US14186649

申请日：2014-02-21

申请人： Spectra Analysis Instruments, Inc.

发明人： William W. Carson ,  Sidney Bourne

IPC分类号： G01N30/12 ,  G01N35/10 ,  B01D15/08 ,  B01D45/12 ,  H01J49/00 ,  B01D1/22 ,  B01D1/00 ,  B01D19/00 ,  G01N30/84 ,  B01D1/16 ,  G01N30/74

CPC分类号： B01D1/222 ,  B01D1/0094 ,  B01D1/16 ,  B01D19/0026 ,  B01D19/0052 ,  B01D19/0057 ,  G01N30/84 ,  G01N2030/743 ,  G01N2030/8494 ,  Y10T436/111666 ,  Y10T436/255 ,  Y10T436/25875

摘要： Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets. When the droplets are sufficiently small, Stokes drag from the exiting solvent vapor carries the droplets out through the center of the cylindrical cavity. After exiting, the superheated solvent vapor further dries the droplets. Solvent vapor is removed by condensation onto a cooled surface. A freezing point reducing agent may be added to improve removal of solvent condensate. Stokes drag from a non-condensable gas maintains the dried droplets in suspension. This suspension travels through an orifice that focuses the impaction of the dried droplets onto the optical surface for infrared analysis. The deposition surface is in an evacuated chamber and is temperature controlled to freeze liquid solutes yet allowing sublimation of residual solvent.

摘要翻译： 公开了在保持溶解的基底的时间分辨率的同时使流动的液体流脱溶的方法和装置。 一种新颖的小型自调节喷雾干燥器保持时间分辨率，同时对液相色谱洗脱液流进行脱溶剂并将溶质沉积在光学表面上用于红外光谱分析。 将液体洗脱液泵送通过加热的雾化器以产生含有液体和溶剂蒸气的溶质的高速射流。 该射流沿周向定向在热的圆柱形空腔内。 离心力使较大的液滴沿腔的外径行进。 加热空腔表面以使液滴沸腾。 薄膜沸腾减少与空腔表面的液滴接触，从而将溶质保留在液滴中。 通过控制溶剂从液滴蒸发的压力来限制溶质温度。 当液滴足够小时，来自离开的溶剂蒸气的斯托克斯阻力将液滴通过圆柱形空腔的中心带出。 离开后，过热溶剂蒸气进一步干燥液滴。 溶剂蒸气通过冷凝除去冷却的表面。 可以加入凝固点还原剂以改善溶剂冷凝物的去除。 来自不可冷凝气体的斯托克斯阻力将干燥的液滴保持在悬浮状态。 该悬浮液通过孔将干燥小滴的冲击聚焦到光学表面上用于红外分析。 沉积表面处于抽真空室中并进行温度控制以冷冻液体溶质，同时允许残留溶剂升华。

公开(公告)号：US20110005305A1

公开(公告)日：2011-01-13

申请号：US12517946

申请日：2007-12-06

申请人： Zhi Xu ,  Rakesh Bose ,  James M. Anderson

发明人： Zhi Xu ,  Rakesh Bose ,  James M. Anderson

IPC分类号： G01N30/28

CPC分类号： G01N30/84 ,  G01N30/74 ,  G01N2030/8447 ,  G01N2030/847 ,  G01N2030/8494

摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.

摘要翻译： 用于液相色谱检测器的流量控制器。 流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。 控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。 流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流。

公开(公告)号：US20100038299A1

公开(公告)日：2010-02-18

申请号：US12581940

申请日：2009-10-20

申请人： Akihiro MATABE

发明人： Akihiro MATABE

IPC分类号： B01D15/40

CPC分类号： B01D45/16 ,  B01D15/40 ,  B01D19/0005 ,  B01D19/0015 ,  G01N2030/8494

摘要： A method comprising liquefying a gas to thereby obtain a liquefied gas; injecting a sample into a mobile phase containing a solvent and a supercritical fluid formed from the liquefied gas; passing this mobile phase through a column so that the mobile phase containing desired substance is divided into the solvent and the gas; and separating the desired substance from the solvent, wherein when the pressure of the gas divided from the mobile phase is higher than the pressure of the gas fed for formation of the liquefied gas from gas supply device, the gas divided from the mobile phase is liquefied. Further, there is provided a vapor liquid separator for use in the method.

摘要翻译： 一种包括液化气体从而获得液化气体的方法; 将样品注入含有由液化气体形成的溶剂和超临界流体的流动相中; 使该流动相通过柱，使含有所需物质的流动相分成溶剂和气体; 并将所需物质与溶剂分离，其中当从流动相中分离的气体的压力高于从气体供应装置形成液化气体的气体的压力时，从流动相中分离的气体被液化 。 此外，提供了一种用于该方法的蒸气分离器。

公开(公告)号：US20050226765A1

公开(公告)日：2005-10-13

申请号：US10362983

申请日：2001-08-17

申请人： Joanne Bone ,  Roger Smith ,  Barry Sharp

发明人： Joanne Bone ,  Roger Smith ,  Barry Sharp

IPC分类号： G01N27/62 ,  G01N21/72 ,  G01N27/447 ,  G01N30/68 ,  G01N30/84 ,  G01N27/00

CPC分类号： G01N30/68 ,  G01N2030/8464 ,  G01N2030/847 ,  G01N2030/8494

摘要： There is disclosed an analyte detection system comprising: and analyte analysis stage through which a condensed phase containing the analyte flows; nebuliser means into which the output of the analyte analysis stage is introduced, the nebuliser means producing an analyte containing aerosol; a flame based analyte detector, and means for introducing the analyte containing aerosol into said flame based anylte detector; in which the condensed phase produces no or negligible response from flame based analyte detector, and I) the system can operate at condensed phase flow rates of greater than 20 μl min−1, preferably greater than 50 μl min−1, most preferably greater than 100 μl min−1; and/or ii) the means for introducing the analyte containing aerosol into said flame based detector comprises a spray chamber

摘要翻译： 公开了一种分析物检测系统，包括：分析物分析阶段，含有分析物的凝聚相通过该阶段流动; 引入分析物分析阶段的输出的雾化器装置，喷雾器意味着产生含有分析物的气溶胶; 基于火焰的分析物检测器，以及用于将含有分析物的气溶胶引入所述基于火焰的阴茎检测器的装置; 其中冷凝相从基于火焰的分析物检测器产生无或可忽略的响应，以及I）系统可以在大于20mil min -1的冷凝相流速下操作，优选大于50mul min 最优选大于100mil min -1; 和/或ii）用于将含有分析物的气溶胶引入所述基于火焰的检测器的装置包括喷雾室

公开(公告)号：US06229605B1

公开(公告)日：2001-05-08

申请号：US09523108

申请日：2000-03-10

申请人： Mark C. Benedict

发明人： Mark C. Benedict

IPC分类号： G01N2100

CPC分类号： G01N30/74 ,  G01N15/065 ,  G01N2015/0261 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N21/47

摘要： The present invention is directed to a device for evaporative light scattering detection that can be used for a wide range of sample types and mobile phases. The device may be quickly converted between a single flow and a split flow configuration through the use of a retractable impactor.

摘要翻译： 本发明涉及一种可用于各种样品类型和流动相的蒸发光散射检测装置。 可以通过使用可伸缩冲击器在单流和分流构造之间快速地转换装置。

公开(公告)号：US6152989A

公开(公告)日：2000-11-28

申请号：US147449

申请日：1998-12-28

申请人： Tadao Ogawa ,  Masayuki Matsui ,  Takanori Mizuno ,  Masae Inoue

发明人： Tadao Ogawa ,  Masayuki Matsui ,  Takanori Mizuno ,  Masae Inoue

IPC分类号： B01D1/00 ,  G01N1/40 ,  G01N30/28 ,  G01N30/46 ,  G01N30/84 ,  B01D15/08

CPC分类号： G01N1/40 ,  B01D1/00 ,  B01D1/0011 ,  G01N30/84 ,  G01N2001/4027 ,  G01N2030/8411 ,  G01N2030/8441 ,  G01N2030/8494 ,  G01N30/28 ,  G01N30/462

摘要： A solute and a solvent with close boiling points or close polarities are separated and concentrated by vaporizing at least one of the solvent and solute, and selectively adsorbing the vaporized component in an apparatus having a vessel, and an absorbent with an opening into the vessel.

摘要翻译： PCT No.PCT / JP98 / 01816 Sec。 371日期1998年12月28日第 102（e）日期1998年12月28日PCT提交1998年4月21日PCT公布。 第WO98 / 49554号公报 日期：1998年11月5日通过蒸发溶剂和溶质中的至少一种，并且在具有容器的设备中选择性吸附汽化组分，并且将具有沸点或极性极性的溶剂和吸收剂 进入船只。

公开(公告)号：US11835497B2

公开(公告)日：2023-12-05

申请号：US17869244

申请日：2022-07-20

申请人： Activated Research Company, LLC

发明人： Andrew Jones ,  Tommy Saunders ,  Mike Hofflander

IPC分类号： G01N30/64 ,  G01N30/38 ,  G01N30/34 ,  G01N30/02 ,  G01N30/84

CPC分类号： G01N30/64 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/347 ,  G01N2030/8417 ,  G01N2030/8447 ,  G01N2030/8494

摘要： In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, and acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable.

公开(公告)号：US20140224638A1

公开(公告)日：2014-08-14

申请号：US14186649

申请日：2014-02-21

申请人： SPECTRA ANALYSIS INSTRUMENTS, INC.

发明人： William W. CARSON ,  Sidney BOURNE

IPC分类号： B01D1/22

CPC分类号： B01D1/222 ,  B01D1/0094 ,  B01D1/16 ,  B01D19/0026 ,  B01D19/0052 ,  B01D19/0057 ,  G01N30/84 ,  G01N2030/743 ,  G01N2030/8494 ,  Y10T436/111666 ,  Y10T436/255 ,  Y10T436/25875

摘要： Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets. When the droplets are sufficiently small, Stokes drag from the exiting solvent vapor carries the droplets out through the center of the cylindrical cavity. After exiting, the superheated solvent vapor further dries the droplets. Solvent vapor is removed by condensation onto a cooled surface. A freezing point reducing agent may be added to improve removal of solvent condensate. Stokes drag from a non-condensable gas maintains the dried droplets in suspension. This suspension travels through an orifice that focuses the impaction of the dried droplets onto the optical surface for infrared analysis. The deposition surface is in an evacuated chamber and is temperature controlled to freeze liquid solutes yet allowing sublimation of residual solvent.

摘要翻译： 公开了在保持溶解的基底的时间分辨率的同时使流动的液体流脱溶的方法和装置。 一种新颖的小型自调节喷雾干燥器保持时间分辨率，同时对液相色谱洗脱液流进行脱溶剂并将溶质沉积在光学表面上用于红外光谱分析。 将液体洗脱液泵送通过加热的雾化器以产生含有液体和溶剂蒸气的溶质的高速射流。 该射流沿周向定向在热的圆柱形空腔内。 离心力使较大的液滴沿腔的外径行进。 加热空腔表面以使液滴沸腾。 薄膜沸腾减少与空腔表面的液滴接触，从而将溶质保留在液滴中。 通过控制溶剂从液滴蒸发的压力来限制溶质温度。 当液滴足够小时，来自离开的溶剂蒸气的斯托克斯阻力将液滴通过圆柱形空腔的中心带出。 离开后，过热溶剂蒸气进一步干燥液滴。 溶剂蒸气通过冷凝除去冷却的表面。 可以加入凝固点还原剂以改善溶剂冷凝物的去除。 来自不可冷凝气体的斯托克斯阻力将干燥的液滴保持在悬浮状态。 该悬浮液通过孔将干燥小滴的冲击聚焦到光学表面上用于红外分析。 沉积表面处于抽真空室中并进行温度控制以冷冻液体溶质，同时允许残留溶剂升华。