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公开(公告)号：US10940210B2
公开(公告)日：2021-03-09
申请号：US17017171
申请日：2020-09-10
摘要： The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
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公开(公告)号：US10935552B2
公开(公告)日：2021-03-02
申请号：US15737187
申请日：2016-06-24
发明人： Benzhong Tang , Engui Zhao , Chen Gui , Meijuan Jiang , Haiqin Deng , Wai Tung Leung , Zhiming Wang , Yueyue Zhao , Tsz Kin Kwok , Lucia Viglianti , Ni Xie
IPC分类号： C09K11/06 , G01N33/58 , C08G65/00 , A61K49/00 , A61K41/00 , A61K31/4706 , A61K31/47 , A61K33/22 , A61K31/5375 , A61K31/695 , C09B23/04 , C09B26/02 , C09B57/00
摘要： The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.
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公开(公告)号：US10894088B2
公开(公告)日：2021-01-19
申请号：US16463747
申请日：2017-11-24
摘要： The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
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公开(公告)号：US10806768B2
公开(公告)日：2020-10-20
申请号：US15607420
申请日：2017-05-26
申请人： Stephen N. Pitcher , Danny Purser
发明人： Stephen N. Pitcher , Danny Purser
IPC分类号： A61K38/06 , A61K31/198 , A61K33/24 , A61K31/4415 , A61K33/30 , A61K33/22 , A61K31/717 , A61K33/42 , A61K33/06
摘要： The present disclosure relates to a composition to aid in heavy metal detox. Metallothioneins (MT) are a family of cysteine-rich enzymes in the body that help remove and regulate heavy metals, copper, and other metals. Amino Acids in combination with zinc and/or molybdenum may provide improved production of MT over amino acid or zinc supplements alone. Additionally, Vitamin B6, Molybdenum, and Boron may be included to further enhance the efficacy of the composition.
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15.发明授权公开(公告)号：US10646514B2
公开(公告)日：2020-05-12
申请号：US15478742
申请日：2017-04-04
IPC分类号： C03C10/00 , A61K8/25 , A61L27/10 , A61L27/56 , C03C4/00 , A61K33/42 , A61L27/54 , A61L26/00 , C03C3/097 , A61K33/14 , A61K33/08 , A61K33/22 , A61Q11/00 , C03C1/00 , A61L27/52 , C03B19/12 , C03B32/02
摘要： Methods for processing and or removing organic residuals and or impurities from a solgel-derived bioactive glass-ceramic and compositions comprising solgel-derived bioactive glass-ceramics processed using these methods, are described.
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公开(公告)号：US20190247419A1
公开(公告)日：2019-08-15
申请号：US16129385
申请日：2018-09-12
申请人： Allergan, Inc.
发明人： Joseph G. Vehige , Peter A. Simmons
IPC分类号： A61K31/717 , A61K36/47 , A61K33/22 , A61K31/205 , A61K47/38 , A61K47/32 , A61K31/047 , A61K47/10 , A61K9/00 , A61K31/745 , A61K31/34 , A61K47/26
CPC分类号： A61K31/717 , A61K9/0048 , A61K31/047 , A61K31/205 , A61K31/34 , A61K31/745 , A61K33/22 , A61K36/47 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.
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公开(公告)号：US20190209608A1
公开(公告)日：2019-07-11
申请号：US15863467
申请日：2018-01-05
发明人： JEN-CHUNG CHEN , CHIH-HUNG LIN
摘要： A drinking water composition for improving the metabolism comprises magnesium, sodium, potassium, calcium and at least one of trace elements selected from the group consisting of chromium, boron, silicon, zinc, selenium, molybdenum, iodine and combinations thereof, in specific proportions. It is experimentally found that the drinking water composition can not only activate the expression of blood glucose regulation genes, but also has a positive impact on the fat storage capacity of cells, and can achieve the effect of improving the metabolism.
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公开(公告)号：US10117885B2
公开(公告)日：2018-11-06
申请号：US15662212
申请日：2017-07-27
发明人： Robert A. Settineri
IPC分类号： A61K31/702 , A61K31/661 , A61K9/00 , A23D9/013 , A61K38/28 , A61K38/44 , A61K45/06 , A61K47/12 , A61K47/24 , A61K47/26 , A61K31/05 , A61K31/122 , A61K31/16 , A61K31/375 , A61K31/385 , A61K31/522 , A61K31/593 , A61K31/66 , A61K31/683 , A61K31/685 , A61K31/7028 , A61K31/716 , A61K31/733 , A61K33/22 , A23L29/10 , A23L29/244 , A23L33/105 , A23L33/115 , A23L33/12 , A61P39/06 , A61P21/00
摘要： Composition, preferably, in the form of capsules or chewable wafers in quantities suitable for relieving the symptoms of fibromyalgia comprise formulations of phospholipids, specifically identified concentrations of phosphatidylglycerol, phosphatidic acid, phosphatidylethanolamine, phosphatidylcholine, glycolipids and phosphatidylserine along with inulin and other desirable active ingredients are described.
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公开(公告)号：US10016450B2
公开(公告)日：2018-07-10
申请号：US15357230
申请日：2016-11-21
IPC分类号： A61K36/00 , A61K31/704 , A23L2/60 , A61K31/7042 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/24 , A61K33/40 , A23L2/52 , A61K33/20 , A61K33/42 , A61K35/08 , A61K33/32 , A23K20/121 , A23L27/30 , A23L33/105 , A23L33/16 , A61K33/04 , A61K33/16 , A61K33/18 , A61K33/22 , A61K33/26 , A61K33/28 , A61K33/30 , A61K33/34 , A61K33/36 , A61K33/38 , A61K33/44
CPC分类号： A61K31/704 , A23K20/121 , A23L2/52 , A23L2/60 , A23L27/36 , A23L33/105 , A23L33/16 , A23V2002/00 , A61K31/7042 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/14 , A61K33/16 , A61K33/18 , A61K33/20 , A61K33/22 , A61K33/24 , A61K33/245 , A61K33/26 , A61K33/28 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/36 , A61K33/38 , A61K33/40 , A61K33/42 , A61K33/44 , A61K35/08 , A61K2300/00
摘要： The present invention comprises compositions that provide anti-glycation activity comprising a mineral extract composition or a mogroside/mineral extract composition or a mogroside composition. Such compositions are useful for methods of preventing, treating and inhibiting the effects of glycation in the body. The methods of the present invention comprise use of anti-glycation composition for the treatment and prevention of glycation related conditions including diabetes, atherosclerosis, arthritis, mental conditions and vision impairment.
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公开(公告)号：US10010081B2
公开(公告)日：2018-07-03
申请号：US15454859
申请日：2017-03-09
IPC分类号： A61K31/728 , A61K33/20 , A61K33/40 , A61K33/22 , A61K9/00 , A61L12/10 , A01N59/00 , A61L12/12 , A61K33/00 , A61K33/14
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
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