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    Process for preparing nitriles
    11.
    发明授权
    Process for preparing nitriles 失效
    制备NITRILES的方法

    公开(公告)号：US3699147A

    公开(公告)日：1972-10-17

    申请号：US3699147D

    申请日：1969-04-04

    申请人： LUMMUS CO

    发明人： HUIBERS DERK TH A ,  WALLER JOHN J

    IPC分类号： C07C255/51 ,  C07C121/02 ,  C07C121/32 ,  C07C121/50

    CPC分类号： C07C253/26 ,  C07C253/28 ,  C07C255/51 ,  C07C255/08

    摘要： A process for the production of a nitrile having three to 12 carbon atoms per molecule by contacting at a temperature of 400* to 500* C and a contact time of 10 to 0.1 seconds a gaseous mixture of hydrocarbons of three to 12 carbon atoms containing the group AND AMMONIA WITH AN IRON AND ARSENIC CONTAINING CATALYST HAVING AN ATOMIC RATIO OF IRON TO ARSENIC OF 1.1:1 TO 10:1 PREPARED BY ADDING AN AQUEOUS ARSENATE SALT SOLUTION TO AN AQUEOUS FERRIC SALT SOLUTION, ADJUSTING, THE PH value of the resulting solution to between 0.5 and 6, evaporating and calcining the product.

    摘要翻译： 通过在400-500℃的温度和10至0.1秒的接触时间内接触含有三至十二个碳原子的烃的气体混合物，每分子生产具有三至十二个碳原子的腈的方法， 将含有铁原子比的铁和亚砷酸的组合物和含有铁的原子比为1.1:1至10:1的氨基酸通过将水溶性盐溶液加入到水溶液中来制备溶液，调节所得溶液的PH值 在0.5至6之间，蒸发并煅烧产品。

    Sulfur-substituted diphenyl ethers having antiviral activity
    16.
    发明授权
    Sulfur-substituted diphenyl ethers having antiviral activity 失效
    具有抗病毒活性的硫取代二苯醚

    公开(公告)号：US4505929A

    公开(公告)日：1985-03-19

    申请号：US408362

    申请日：1982-08-16

    申请人： Lowell D. Markley ,  Yulan C. Tong ,  Steven G. Wood

    发明人： Lowell D. Markley ,  Yulan C. Tong ,  Steven G. Wood

    IPC分类号： C07C317/22 ,  A01N37/34 ,  C07C121/50 ,  C07C143/74 ,  C07C143/78

    CPC分类号： C07C317/22

    摘要： Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3; and R.sub.4 represents cyano or dialkylamino; or alternatively R.sub.2 and R.sub.3 taken together represent the radical --O--C(X).sub.2 --O-- wherein X represents hydrogen, bromo, chloro or fluoro.

    摘要翻译： 公开了具有抗病毒活性的新型化合物，这些化合物由下式表示：其中m表示整数0,1或2; R代表三卤甲基，烷基或苯基; R 1表示氢，溴，氯，氟，氰基，硝基，氨基，烷基，烷氧基或三氟甲基; R 2表示羟基，溴，氯，氟，氰基，乙酰基，苯甲酰基，取代的苯甲酰基，烷基，烷氧基，取代的烷氧基，苄基，取代的苄基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基磺酰基，二烷基氨基磺酰基或基团-O（CH 2）n R 4 其中n表示整数1,2或3，R 4表示氰基或二烷基氨基; R 3表示氢，羟基，溴，氯，氟，氰基，乙酰基，苯甲酰基，取代的苯甲酰基，烷基，烷氧基，取代的烷氧基，苄基，取代的苄基，烷硫基，烷基亚磺酰基，烷基磺酰基，烷基氨基磺酰基，二烷基氨基磺酰基或基团-O ）nR 4其中n表示整数1,2或3; 并且R 4表示氰基或二烷基氨基; 或者R2和R3一起代表基团-O-C（X）2-O-，其中X表示氢，溴，氯或氟。

    Nucleophilic substitution process
    17.
    发明授权
    Nucleophilic substitution process 失效
    亲核取代过程

    公开(公告)号：US4502996A

    公开(公告)日：1985-03-05

    申请号：US452615

    申请日：1982-12-23

    申请人： G. Patrick Stahly

    发明人： G. Patrick Stahly

    IPC分类号： C07C255/32 ,  C07C121/50

    CPC分类号： C07C255/00

    摘要： Halonitroarylacetonitriles are prepared by reacting a halonitroaromatic compound wherein the halo substituent has an atomic number of at least 17 with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the halonitroaromatic compound during which an alpha-substituent functions as a leaving group. The halonitroarylacetonitriles formed by the process can be readily converted into derivatives, such as pharmaceuticals.

    摘要翻译： 卤代四芳基乙腈通过卤代卤代芳族化合物制备，其中卤素取代基具有至少17的原子序数与α，α-二取代的乙腈在惰性溶剂中并在碱的存在下反应，使腈在未取代的基团上进行亲核取代 卤代硝基芳族化合物的环碳，其中α-取代基用作离去基团。 通过该方法形成的卤代四芳基乙腈可以容易地转化为衍生物，例如药物。

    Nucleophilic substitution process
    18.
    发明授权
    Nucleophilic substitution process 失效
    亲核取代过程

    公开(公告)号：US4502995A

    公开(公告)日：1985-03-05

    申请号：US452518

    申请日：1982-12-23

    申请人： Barbara C. Stahly ,  G. Patrick Stahly

    发明人： Barbara C. Stahly ,  G. Patrick Stahly

    IPC分类号： C07C63/33 ,  C07C255/32 ,  C07C121/50

    CPC分类号： C07C255/00

    摘要： Fluoronitrolarylacetonitriles are prepared by reacting a fluoronitroaromatic compound having a nitro substituent, at least one fluoro substituent, and at least one replaceable hydrogen on (1) a benzene ring bearing at least one other innocuous substituent, (2) a heterocyclic aromatic ring, or (3) a carbocyclic aromatic ring of a polycyclic ring structure with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the fluoronitroaromatic compound during which an alpha-substituent functions as a leaving group.

    摘要翻译： 氟化芳基芳基乙腈通过在（1）含有至少一个其他无害取代基的苯环上反应具有硝基取代基的氟代芳基化合物，至少一个氟取代基和至少一个可取代的氢，（2）杂环芳族环或（ 3）具有α，α-二取代的乙腈的多环环结构的碳环芳环在惰性溶剂中并在碱的存在下，使得腈在氟代芳族化合物的未取代的环碳上经历亲核取代，其中 α-取代基用作离去基团。