公开(公告)号：US20190242888A1

公开(公告)日：2019-08-08

申请号：US16277618

申请日：2019-02-15

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： Richard S. Larson ,  Brian Hjelle ,  Pam R. Hall ,  David C. Brown ,  Marco Bisoffi ,  Susan M. Brozik ,  Darren W. Branch ,  Thayne L. Edwards ,  David Wheeler

IPC: G01N33/543 ,  G01N33/553 ,  C12Q1/6825 ,  G01N29/032

CPC classification number: G01N33/54373 ,  C12Q1/6825 ,  G01N29/032 ,  G01N33/553 ,  G01N2291/0422

Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

公开(公告)号：US10365269B2

公开(公告)日：2019-07-30

申请号：US15577809

申请日：2016-06-02

Applicant: STC.UNM ,  Charles Melancon ,  Shijie Huang

Inventor： Charles Melancon ,  Shijie Huang

IPC: G01N33/50 ,  C12Q1/68 ,  G01N33/53 ,  C12Q1/6897 ,  G01N33/533

Abstract: This disclosure describes a cell genetically modified to detect ribosome inhibition in the cell and methods involving such a cell. Generally, the genetically-modified cell includes an aminoglycoside-sensitive orthogonal 16S rRNA (O-16S) coding region bearing a mutated anti-Shine-Dalgarno (O-ASD) sequence, a repressor/operator system, and a polynucleotide encoding a detectable reporter under transcriptional control of the repressor/operator system. The repressor/operator system includes a coding region that encodes a transcriptional regulator and having an orthogonal SD (O-SD) sequence complementary to the 16S rRNA O-ASD sequence. The operator sequence, which is repressable by the transcriptional regulator, is operably linked to the polynucleotide encoding a detectable reporter.

公开(公告)号：US10317212B1

公开(公告)日：2019-06-11

申请号：US15984048

申请日：2018-05-18

Applicant: STC.UNM

Inventor： Jean-Claude Diels ,  Ladan Arissian ,  Matthias Lenzner ,  James Hendrie

IPC: G01C19/66 ,  G01C19/70

Abstract: Apparatus, systems, and methods associated with enhancement of phase response of intracavity phase interferometers are applicable in a variety of applications.

公开(公告)号：US20190160047A1

公开(公告)日：2019-05-30

申请号：US16262461

申请日：2019-01-30

Applicant: STC.UNM

Inventor： Eric R. Prossnitz ,  Matthias Barton ,  Matthias R. Meyer

IPC: A61K31/436 ,  A61K31/16 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/435

Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).

公开(公告)号：US10278649B2

公开(公告)日：2019-05-07

申请号：US15531135

申请日：2015-11-24

Applicant: STC.UNM

Inventor： Majeed M. Hayat ,  Sanjay Krishna ,  Sebastian Eugenio Godoy ,  David A. Ramirez

IPC: G06K9/00 ,  A61B5/00 ,  A61B5/01 ,  G06F19/00 ,  G06T7/62 ,  G06T7/68 ,  G06T7/277 ,  G06T7/13 ,  G06T7/174 ,  G06T7/90 ,  G16H50/20 ,  G06K9/62 ,  G06T7/00 ,  G06T7/40

Abstract: A technique for classifying lesions as malignant or benign is disclosed. The technique can include: cooling an area of skin including a lesion of a patient to initiate a warm-up process; receiving a temporal sequence of thermal images of the area of skin representing a thermal recovery of the area of skin, the temporal sequence of thermal images generated by an infrared camera; generating a temporal profile of the thermal recovery based on the temporal sequence of thermal images; analyzing temporal statistical properties of the temporal profile; determining a malignancy probability that the lesion is malignant based on an analysis of the temporal profile, wherein the determining includes extracting one or more statistical features based on continuous-time stochastic signals in the sequence of thermal images; and classifying the lesion based on the malignancy probability.

公开(公告)号：US10261084B1

公开(公告)日：2019-04-16

申请号：US14626536

申请日：2015-02-19

Applicant: STC.UNM

Inventor： Tione Buranda ,  Jacob Ongudi Agola ,  Soumik BasuRay ,  Scarlett Swanson ,  Angela Wandinger-Ness ,  Peter C. Simons ,  Virginie Bondu

IPC: G01N33/573 ,  G01N33/86

Abstract: In one embodiment, the invention provides a method of diagnosing sepsis or a virus-related infection (often a viral hemorrhagic fever infection) in a subject by detecting and measuring the level of a set of sepsis and virus infection-associated-GTPase biomarkers in a sample obtained from the subject using multiplexed flow cytometry. Related kits are also provided. In a preferred embodiment, the invention provides point of care diagnostic methods for determining an early stage sepsis or the severity of a virus infection, especially in a hospital or other setting.

公开(公告)号：US10183032B2

公开(公告)日：2019-01-22

申请号：US15691977

申请日：2017-08-31

Applicant: Ball State Innovation Corporation ,  STC.UNM

Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

IPC: A61K31/415 ,  A61K31/63 ,  A61K31/635

Abstract: The present disclosure relates to molecules that function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.

公开(公告)号：US10174042B2

公开(公告)日：2019-01-08

申请号：US15348756

申请日：2016-11-10

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Eunkyung Ji ,  Motokatsu Ogawa ,  Thomas S. Corbitt ,  Dimitri Dascier ,  Ying Wang ,  Linnea K. Ista ,  Eric H. Hill

IPC: C07D487/08 ,  C07C217/14 ,  C07C309/11 ,  C07C217/20 ,  C07C309/24 ,  C07D333/16 ,  C08G61/02 ,  C08G75/00 ,  C08G61/12

Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

公开(公告)号：US20180358226A1

公开(公告)日：2018-12-13

申请号：US15573772

申请日：2016-05-13

Applicant: STC.UNM

Inventor： Seung-Chang Lee ,  Steven R.J. Brueck

IPC: H01L21/02 ,  H01L21/311 ,  H01L21/306 ,  H01L21/285 ,  H01L21/8238 ,  H01L27/092 ,  H01L29/06 ,  H01L29/423 ,  H01L29/66 ,  H01L29/786

CPC classification number: H01L21/02664 ,  B81C1/00111 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02236 ,  H01L21/02381 ,  H01L21/02433 ,  H01L21/02532 ,  H01L21/02535 ,  H01L21/02546 ,  H01L21/02603 ,  H01L21/02639 ,  H01L21/02645 ,  H01L21/02653 ,  H01L21/2855 ,  H01L21/30608 ,  H01L21/31116 ,  H01L21/823807 ,  H01L27/092 ,  H01L27/0922 ,  H01L29/0673 ,  H01L29/42392 ,  H01L29/66742 ,  H01L29/78681 ,  H01L29/78684 ,  H01L29/78696

Abstract: Provided is a method for growing a nanowire, including: providing a substrate with a base portion having a first surface and at least one support structure extending above or below the first surface; forming a dielectric coating on the at least one support structure; forming a photoresist coating over the substrate; forming a metal coating over at least a portion of the dielectric coating; removing a portion of the dielectric coating to expose a surface of the at least one support structure; removing a portion of the at least one support structure to form a nanowire growth surface; growing at least one nanowire on the nanowire growth surface of a corresponding one of the at least one support structure, wherein the nanowire comprises a root end attached to the growth surface and an opposing, free end extending from the root end; and elastically bending the at least one nanowire.

公开(公告)号：US20180357744A1

公开(公告)日：2018-12-13

申请号：US15780052

申请日：2016-12-16

Applicant: STC.UNM

Inventor： Marios Stephanou PATTICHIS ,  Cesar CARRANZA ,  Daniel LLAMOCCA OBREGON

IPC: G06T1/20 ,  G06K9/52 ,  G06K9/46 ,  G06K9/00

CPC classification number: G06T1/20 ,  G06F17/153 ,  G06K9/00986 ,  G06K9/4642 ,  G06K9/522 ,  G06T2210/52

Abstract: Fast and scalable architectures and methods adaptable to available resources, that (1) compute 2-D convolutions using 1-D convolutions, (2) provide fast transposition and accumulation of results for computing fast cross-correlations or 2-D convolutions, and (3) provide parallel computations using pipelined 1-D convolvers. Additionally, fast and scalable architectures and methods that compute 2-D linear convolutions using Discrete Periodic Radon Transforms (DPRTs) including the use of scalable DPRT, Fast DPRT, and fast 1-D convolutions.