公开(公告)号：US20170215777A1

公开(公告)日：2017-08-03

申请号：US15492992

申请日：2017-04-20

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode, JR. ,  Apurv Ullas Kamath ,  James Patrick Thrower ,  Ben Xavier

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61B5/7475 ,  A61M5/1723 ,  G06F19/00 ,  Y02A90/22 ,  Y02A90/26

Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

公开(公告)号：US20170128021A1

公开(公告)日：2017-05-11

申请号：US15415522

申请日：2017-01-25

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  James H. Brauker ,  Aarthi Mahalingam ,  Ying Li

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/7203 ,  A61B5/01 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7225 ,  A61B5/7239 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/742 ,  A61B2560/0252 ,  Y02A90/22 ,  Y02A90/26

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

公开(公告)号：US09597453B2

公开(公告)日：2017-03-21

申请号：US14063811

申请日：2013-10-25

Applicant: DexCom, Inc.

Inventor： John Michael Dobbles ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  James H. Brauker

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  G06F19/00 ,  A61B5/00 ,  A61M5/00 ,  A61M5/178 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61M5/003 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/178 ,  A61M5/20 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/008 ,  A61M15/0083 ,  A61M35/00 ,  A61M2005/14296 ,  A61M2205/3569 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

公开(公告)号：US09597027B2

公开(公告)日：2017-03-21

申请号：US14529034

申请日：2014-10-30

Applicant: DexCom, Inc.

Inventor： James R. Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

IPC: A61B5/1486 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

公开(公告)号：US20170055889A1

公开(公告)日：2017-03-02

申请号：US15347687

申请日：2016-11-09

Applicant: DexCom, Inc.

Inventor： Andrew P. Rasdal ,  James H. Brauker ,  Paul V. Neale ,  Peter C. Simpson

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/07 ,  A61B5/145

Abstract: A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.

Abstract translation: 提供一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器和从连续葡萄糖传感器接收数据流并使用单点校准数据流的集成接收器 与集成接收器集成的葡萄糖监测器。 集成接收器从单点葡萄糖监测器获得葡萄糖值，校准从连续葡萄糖传感器接收的传感器数据流，并在用户界面上显示单点葡萄糖测量值和校准的连续葡萄糖传感器值中的一个或两个。

公开(公告)号：US20160354018A1

公开(公告)日：2016-12-08

申请号：US15224325

申请日：2016-07-29

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode, JR. ,  Apurv Ullas Kamath ,  James Patrick Thrower ,  Ben Xavier

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61B5/7475 ,  A61M5/1723 ,  G06F19/00 ,  Y02A90/22 ,  Y02A90/26

Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

公开(公告)号：US20160157766A1

公开(公告)日：2016-06-09

申请号：US15042967

申请日：2016-02-12

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Sebastian Bohm ,  James H. Brauker ,  Paul V. Neale

IPC: A61B5/1486 ,  A61B5/00

CPC classification number: A61B5/14865 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6843 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0443 ,  A61B2562/04

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

公开(公告)号：US20150374270A1

公开(公告)日：2015-12-31

申请号：US14842276

申请日：2015-09-01

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/6846

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

Abstract translation: 本发明一般涉及用于测量宿主中分析物的系统和方法。 更具体地，本发明涉及用于经皮和皮下测量宿主中葡萄糖的系统和方法。

公开(公告)号：US09220449B2

公开(公告)日：2015-12-29

申请号：US13938103

申请日：2013-07-09

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, Jr. ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/1473 ,  A61B5/00

CPC classification number: A61B5/1495 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2560/0223

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract translation: 公开了用于处理传感器分析物数据的系统和方法，包括启动校准，更新校准，评估参考和传感器分析物数据的临床可接受性，以及评估传感器校准的质量。 可以使用一个或多个匹配的传感器和参考分析物数据对的校准集来校准传感器。 在分析物传感器插入之前进行台式测试产生的参考数据可用于提供传感器数据的初始校准。 植入用户的短期连续分析物传感器的参考数据可用于初始校准或更新来自长期连续分析物传感器的传感器数据。

公开(公告)号：US20150289819A1

公开(公告)日：2015-10-15

申请号：US14746760

申请日：2015-06-22

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Ying Li ,  Mohammad Ali Shariati ,  James H. Brauker ,  Mark C. Brister ,  Robert Boock

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/7203 ,  A61B5/01 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6848 ,  A61B5/725 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/743 ,  A61B5/7475

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.

Abstract translation: 用于检测噪声发生并响应于此处理分析物传感器数据的系统和方法。 在一些实施例中，处理分析物传感器数据包括过滤传感器数据以减少或消除噪声发作对信号的影响。