Conjugated polyelectrolyte capsules: light activated antimicrobials
    212.
    发明授权
    Conjugated polyelectrolyte capsules: light activated antimicrobials 有权
    共轭聚电解质胶囊:光活化抗菌剂

    公开(公告)号:US09005540B2

    公开(公告)日:2015-04-14

    申请号:US14092409

    申请日:2013-11-27

    Abstract: Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.

    Abstract translation: 中空共轭聚电解质(HCPE)微胶囊含有至少一种共轭聚电解质和至少一种其他互补电荷的聚电解质,微胶囊具有中空芯。 共轭聚电解质是具有多个带电重复单元的聚合物,其中一部分带电重复单元形成π-共轭序列。 互补聚电解质是与共轭聚电解质的带电重复单元具有互补的带电重复单元的聚合物。 HCPE微胶囊可以通过连续地涂覆具有互补聚电解质交替层的牺牲芯形成,其中至少一种是共轭聚电解质。 可以去除牺牲芯以形成HCPE微胶囊的中空中心。 HCPE微胶囊可以与含有微生物的培养基接触,其中HCPE微胶囊与微生物结合,并在用光或其他电磁辐射照射时有效杀死微生物。

    Solid-state microscope for selectively imaging a sample
    214.
    发明授权
    Solid-state microscope for selectively imaging a sample 有权
    用于选择性地成像样品的固态显微镜

    公开(公告)号:US08964020B2

    公开(公告)日:2015-02-24

    申请号:US12103920

    申请日:2008-04-16

    Abstract: Exemplary embodiments provide solid-state microscope (SSM) devices and methods for processing and using the SSM devices. The solid-state microscope devices can include a light emitter array having a plurality of light emitters with each light emitter individually addressable. During operation, each light emitter can be biased in one of three operating states including an emit state, a detect state, and an off state. The light emitter can include an LED (light emitting diode) including, but not limited to, a nanowire based LED or a planar LED to provide various desired image resolutions for the SSM devices. In an exemplary embodiment, for near-field microscopy, the resolution of the SSM microscope can be essentially defined by the pitch p, i.e., center-to-center spacing between two adjacent light emitters, of the light emitter array.

    Abstract translation: 示例性实施例提供了用于处理和使用SSM装置的固态显微镜(SSM)装置和方法。 固态显微镜装置可以包括具有多个发光体的光发射器阵列,每个发光体可单独寻址。 在操作期间,每个光发射器可以被偏置在包括发射状态,检测状态和关闭状态的三种操作状态之一中。 光发射器可以包括LED(发光二极管),其包括但不限于基于纳米线的LED或平面LED,以为SSM器件提供各种期望的图像分辨率。 在一个示例性实施例中,对于近场显微镜,SSM显微镜的分辨率可以基本上由光发射器阵列的间距p,即两个相邻发光体之间的中心到中心间隔定义。

    SIGNAL PROPAGATION BIOMOLECULES, DEVICES AND METHODS
    216.
    发明申请
    SIGNAL PROPAGATION BIOMOLECULES, DEVICES AND METHODS 有权
    信号传播生物分子,设备和方法

    公开(公告)号:US20140349276A1

    公开(公告)日:2014-11-27

    申请号:US14283993

    申请日:2014-05-21

    Abstract: This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

    Abstract translation: 本公开描述了结构化多核苷酸,包括结构化多核苷酸的装置和涉及结构化多核苷酸和/或装置的方法。 通常,结构化多核苷酸包括五个结构域。 第一个域用作输入DNA逻辑门的始发点,以启动与SCS生物分子的结合。 第二个域用作上游DNA逻辑门的底物识别序列。 第三个域用作输出DNA逻辑门的脚注,以启动SCS生物分子与门的结合。 第四个域用作效应序列来改变输出逻辑门的状态。 第五结构域充当笼状序列,以将效应序列锁定在无活性状态,直到输入门结合结构化多核苷酸。

    DNA SAMPLE PREPARATION AND SEQUENCING
    217.
    发明申请
    DNA SAMPLE PREPARATION AND SEQUENCING 有权
    DNA样品制备和测序

    公开(公告)号:US20140329712A1

    公开(公告)日:2014-11-06

    申请号:US14347690

    申请日:2012-09-28

    Applicant: STC.UNM

    Abstract: This disclosure describes, in one aspect, a method for preparing DNA molecule for sequencing. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; annealing a first sequencing primer to the first loop oriented to sequence at least a portion of one strand of the fragment; and annealing a second sequencing primer to the second loop oriented to sequence at least a portion of the other strand of the fragment. In another aspect, this disclosure describes a method for sequencing a DNA molecule. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; and sequencing at least one of the DNA strands.

    Abstract translation: 本公开一方面描述了用于测序的DNA分子的制备方法。 通常,该方法包括将DNA分子片段化成双链片段; 扩增至少一部分双链片段; 使片段环化,使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 将第一测序引物退火至所述第一环,其定向为序列所述片段的一条链的至少一部分; 以及将第二测序引物退火至所述第二环,其定向为序列所述片段的另一条链的至少一部分。 在另一方面,本公开描述了用于测序DNA分子的方法。 通常,该方法包括将DNA分子片段化成双链片段; 扩增至少一部分双链片段; 使片段环化,使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 并测序至少一个DNA链。

    Epitaxial growth of in-plane nanowires and nanowire devices
    219.
    发明授权
    Epitaxial growth of in-plane nanowires and nanowire devices 有权
    平面内纳米线和纳米线器件的外延生长

    公开(公告)号:US08785226B2

    公开(公告)日:2014-07-22

    申请号:US14032904

    申请日:2013-09-20

    Applicant: STC.UNM

    Abstract: Exemplary embodiments provide semiconductor nanowires and nanowire devices/applications and methods for their formation. In embodiments, in-plane nanowires can be epitaxially grown on a patterned substrate, which are more favorable than vertical ones for device processing and three-dimensional (3D) integrated circuits. In embodiments, the in-plane nanowire can be formed by selective epitaxy utilizing lateral overgrowth and faceting of an epilayer initially grown in a one-dimensional (1D) nanoscale opening. In embodiments, optical, electrical, and thermal connections can be established and controlled between the nanowire, the substrate, and additional electrical or optical components for better device and system performance.

    Abstract translation: 示例性实施例提供用于其形成的半导体纳米线和纳米线器件/应用和方法。 在实施例中,平面内纳米线可以在图案化衬底上外延生长,其比用于器件处理和三维(3D)集成电路的垂直纳米线更有利。 在实施方案中,可以通过使用最初在一维(1D)纳米尺度开口中生长的外延层的横向过生长和刻面的选择性外延来形成平面内纳米线。 在实施例中,可以在纳米线,衬底和附加电气或光学部件之间建立和控制光学,电气和热连接,以获得更好的器件和系统性能。

    All solid state optical cryocooler using intracavity optically pumped semiconductor lasers and a method of making the same
    220.
    发明授权
    All solid state optical cryocooler using intracavity optically pumped semiconductor lasers and a method of making the same 有权
    所有使用腔内光泵浦半导体激光器的固态光学低温冷却器及其制造方法

    公开(公告)号:US08720219B1

    公开(公告)日:2014-05-13

    申请号:US12984780

    申请日:2011-01-05

    Abstract: A device and corresponding method for cooling electronics is disclosed. The device is an all-solid-state optical cryocooler and can include an optically pumped semiconductor laser (OPSL); a cavity configured to receive and control absorption of the optically pumped semiconductor laser, the cavity having a high reflection (HR) surface and an anti-reflection (AR) surface; and a doped crystal housed within the cavity, the doped crystal configured to cool in response to input of the optically pumped semiconductor laser. The method can include supplying an intracavity optically pumped semiconductor lasers to a doped crystal within a cavity; and configuring the cavity to include a high reflection (HR) surface and an anti-reflection (AR) surface, the HR surface and AR surface formed on or in connection with the doped crystal to increase pump light absorption at the crystal within the cavity.

    Abstract translation: 公开了一种用于冷却电子设备的装置和相应的方法。 该器件是全固态光学低温冷却器,并且可以包括光泵浦半导体激光器(OPSL); 被配置为接收和控制所述光泵浦半导体激光器的吸收的空腔,所述空腔具有高反射(HR)表面和抗反射(AR)表面; 并且掺杂晶体容纳在腔内,掺杂晶体被配置为响应于光泵浦半导体激光器的输入而冷却。 该方法可以包括向空腔内的掺杂晶体提供腔内光泵浦半导体激光器; 并且将所述空腔配置为包括高反射(HR)表面和抗反射(AR)表面,所述HR表面和AR表面形成在所述掺杂晶体上或与所述掺杂晶体结合,以增加在所述腔内的晶体处的泵浦光吸收。

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