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公开(公告)号：US10066255B2
公开(公告)日：2018-09-04
申请号：US15235950
申请日：2016-08-12
Inventor： Yeon Joon Park , Kang Gyun Park
Abstract: Provided is a blood culture treatment technology, including a novel treatment technology of performing pretreatment of a positive blood culture to effectively remove foreign substances such as cells, etc., thereby omitting a subculturing process on a solid medium and realizing rapid selection of antimicrobial agents for patients. The pretreatment method of a positive blood culture sample for bacterial identification and antimicrobial susceptibility testing includes preparing a first liquid culture by centrifuging a portion of a liquid medium including the positive blood culture sample, washing a precipitate thus centrifuged with a solution including sodium chloride, and then suspending the precipitate in the solution including sodium chloride, and preparing a second liquid culture by passing the first liquid culture thus prepared through a pretreatment filter including a mesh structure.
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公开(公告)号：US10016624B2
公开(公告)日：2018-07-10
申请号：US14894219
申请日：2013-08-05
Inventor： Do Kun Yoon , Joo Young Jung , Tae Suk Suh
CPC classification number: A61N5/1045 , A61N5/10 , A61N2005/1074 , A61N2005/1094 , A61N2005/1095 , G21K1/046
Abstract: A radiation treatment collimator having a multilayered linkage structure, the collimator providing various shapes of spaces to form an irradiation area transmitting radioactive rays therethrough, the collimator comprising: a fixed frame disposed on a plate; multiple pixel board layers fixedly stacked at predetermined intervals on top of each other inside the fixed frame, each pixel board layer being configured in a lattice form and having pixel covers disposed correspondingly to the respective lattices in such a manner as to be open and closed individually; control units disposed on both sides of the fixed frame to individually control the operations of the pixel covers of the pixel board layers; and power source units disposed on the front and rear sides of the fixed frame to supply the pixel board layers with operating power.
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233.发明申请公开(公告)号：US20180080924A1
公开(公告)日：2018-03-22
申请号：US15444335
申请日：2017-02-28
Inventor： Jin-Sung CHOI , Jeong Hee CHOI
IPC: G01N33/50 , G01N33/487 , C07K14/705 , G01N33/68
CPC classification number: G01N33/5014 , C07K14/705 , G01N33/48728 , G01N33/6872 , G01N2333/705 , G01N2500/04 , G01N2500/10
Abstract: Provided are a cell line stably expressing voltage-gated sodium channel (Nav1.5), wherein a SCN5A gene (NCBI accession no. NM_198056) encoding Nav1.5 and a puromycin selection marker are inserted into a chromosome of a host cell, and a method of measuring cardiotoxicity of a test substance comprising: (1) contacting a test substance to the cell line of claim 1; and (2) measuring magnitude of voltage-gated sodium channel (Nav1.5) in the cell line in contact with the test substance.
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公开(公告)号：US20180053110A1
公开(公告)日：2018-02-22
申请号：US15682698
申请日：2017-08-22
Inventor： Hang-Bong KANG , Hyeon-Woo KANG
CPC classification number: G06N7/005 , G06N3/0454 , G06Q10/04 , G06Q50/265 , G08B29/185 , G08B31/00 , H04W4/029
Abstract: Disclosed is a method of predicting crime occurrence in a prediction target region using big data, the method including: collecting crime prediction data of the prediction target region from a plurality of data domains; collecting crime occurrence data of crime that occurred in the prediction target region during a preset period of time from a crime occurrence record domain; analyzing the crime prediction data and the crime occurrence data of each of the data domains according to a statistical analysis, and extracting meaningful data of the crime prediction data as available data by each of the data domains; and predicting crime occurrence by applying the available data to a pre-registered deep learning algorithm, wherein the available data is classified into a plurality of data groups according to a data type, and the deep learning algorithm includes: a first deep neural network; a second deep neural network; and an output.
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公开(公告)号：US09896657B2
公开(公告)日：2018-02-20
申请号：US14823187
申请日：2015-08-11
Inventor： Choun-Ki Joo , Hyun Soo Lee
IPC: C12N15/00 , C12N5/0797 , A61K35/30
CPC classification number: C12N5/0623 , A61K35/30 , C12N5/062 , C12N2500/46 , C12N2500/84 , C12N2501/11 , C12N2501/155 , C12N2501/33 , C12N2501/39 , C12N2506/45
Abstract: The present invention relates to a method of inducing differentiation of a stem cell into a corneal limbal stem cell, and a medium composition used therein. Further, the present invention relates to a pharmaceutical composition for treating corneal damage, including a corneal limbal stem cell differentiated using the above-described method as an active ingredient.
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Patent Agency Ranking
公开(公告)号：US09895558B2
公开(公告)日：2018-02-20
申请号：US15118625
申请日：2015-01-29
Inventor： Do Kun Yoon , Joo Young Jung , Tae Suk Suh
IPC: A61N5/10
CPC classification number: A61N5/1075 , A61N2005/1076
Abstract: The present invention relates to a voxel-type block phantom for a multifunctional radiation measurement apparatus. A phantom, for adjusting an amount of radiation, has solid pixel blocks, having a radiation measuring device equipped therein and different media and densities from one another, assembled on top of one another so as to be assembled into a 3-dimensional voxel, wherein the phantom is formed by placing a solid block which is appropriate for a density that corresponds to each pixel of the 3-dimensional voxel. An inspector can personally and instantly customize a phantom that is appropriate for a subject to be measured and thus can obtain an accurate measurement value.
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公开(公告)号：US09827313B2
公开(公告)日：2017-11-28
申请号：US14670890
申请日：2015-03-27
Applicant: SNU R&DB FOUNDATION , Institute for Basic Science , The Catholic University of Korea Industry-Academic Cooperation Foundation
Inventor： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park , Sin-jung Park , Yang Lu , Kyoung Sub Kim , Michael J. Hackett , Byung Hyo Kim , Hyeona Yim , Yong Sun Jeon
CPC classification number: A61K41/0071 , A61K49/0036 , A61K49/0054 , A61K49/1857
Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.
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238.发明申请公开(公告)号：US20170336490A1
公开(公告)日：2017-11-23
申请号：US15286992
申请日：2016-10-06
Inventor： Tae-Suk SUH , Min-Young LEE , Kyu-Ho SONG
CPC classification number: G01R33/58 , A61B6/032 , A61B6/5247 , A61B6/583 , G01R33/4812
Abstract: The present invention relates to a phantom for quality assurance of magnetic resonance imaging (MRI) and computed tomography (CT) for multi-artifact correction. An aspect of the present invention provides a phantom capable of simultaneously evaluating performance of magnetic resonance imaging (MRI) and computed tomography (CT), the phantom including: a first hemispheric container; and a second hemispheric container which has the same structure and the same size as the first container, in which the first container and the second container are connected by being in direct contact with each other so as to form a symmetrical structure, each of the first container and the second container includes a teeth retainer into which a plurality of teeth mimics, which mimics teeth of a body, is inserted, and an insertion hole into which at least one bone mimic is inserted, and an interior of each of the first container and the second container is filled with at least one solution that mimics a brain metabolite.
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公开(公告)号：US20170333370A1
公开(公告)日：2017-11-23
申请号：US15502981
申请日：2014-08-25
Inventor： Mi-La CHO , Chul-Woo YANG , Dong-Yun SHIN , Min-Jung PARK , Seon-Yeong LEE , Sung-Hee LEE , Eun-Ji YANG , Hye-Jin SON , Eun-Kyung KIM , Jae-Kyung KIM
IPC: A61K31/155 , C07C279/18 , C07C279/26
CPC classification number: A61K31/155 , A61K2121/00 , A61K2300/00 , C07C279/18 , C07C279/26
Abstract: The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.
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240.发明申请公开(公告)号：US20170319592A1
公开(公告)日：2017-11-09
申请号：US15523197
申请日：2015-11-03
Inventor： SEOK GOO CHO , KEON-Il IM , JUNG YEON LIM , NAYOUN KIM , YOUNG SUN NAM , EUN SOL LEE
Abstract: The present invention relates to a composition for preventing or treating mucositis comprising NecroX. It was found that NecroX has effects of reducing the disease mortality rate by means of radiotherapy or chemotherapy in a NecroX administration group, protecting intestinal functions, inhibiting destruction of intestinal mucous membrane, and proliferating the cells present in intestines. NecroX may be used for a pharmaceutical composition for preventing or treating mucositis, an anti-cancer adjuvant, or a food composition.
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