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    WINDOWED SEQUENCING
    251.
    发明申请
    WINDOWED SEQUENCING 审中-公开

    公开(公告)号：US20190106745A1

    公开(公告)日：2019-04-11

    申请号：US16153898

    申请日：2018-10-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark MILGREW ,  Jonathan SCHULTZ ,  Chris PAPALIAS ,  Kim JOHNSON

    IPC: C12Q1/6874 ,  G06F19/22

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.

    Methods, systems, and computer-readable media for compression of sequencing data
    252.
    发明授权
    Methods, systems, and computer-readable media for compression of sequencing data 有权

    公开(公告)号：US10254242B2

    公开(公告)日：2019-04-09

    申请号：US14729640

    申请日：2015-06-03

    Applicant: Life Technologies Corporation

    Inventor： Benjamin Donnet

    IPC: G01N27/414

    Abstract: Methods, systems, and computer-readable media are disclosed for compression of sequencing data. One method includes receiving waveform data associated with a chemical event occurring on a sensor array, the waveform data including a plurality of time-based waveforms of a corresponding plurality of locations of the sensor array; converting, by at least one processor, each time-based waveform of the waveform data into a frequency-domain spectrum; generating, by the at least one processor, a key frame based on a plurality of the frequency-domain spectrums; calculating, by the at least one processor, for each of the frequency-domain spectrums, a difference between the frequency-domain spectrum and the key frame; and encoding, by the at least one processor, each calculated difference between the frequency-domain spectrum and the key frame.

    METHODS FOR DETECTION OF FUSIONS USING COMPRESSED MOLECULAR TAGGED NUCLEIC ACID SEQUENCE DATA
    257.
    发明申请
    METHODS FOR DETECTION OF FUSIONS USING COMPRESSED MOLECULAR TAGGED NUCLEIC ACID SEQUENCE DATA 审中-公开

    公开(公告)号：US20190087539A1

    公开(公告)日：2019-03-21

    申请号：US16136463

    申请日：2018-09-20

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Rajesh GOTTIMUKKALA ,  Cheng-Zong BAI ,  Dumitru BRINZA ,  Jeoffrey SCHAGEMAN ,  Varun BAGAI

    IPC: G06F19/22 ,  C12Q1/6853

    Abstract: A method for compressing nucleic acid sequence data wherein each sequence read is associated with a molecular tag sequence, wherein a portion of the sequence reads alignments correspond to sequence reads mapped to a targeted fusion reference sequence includes determining a consensus sequence read for each family of sequence reads based on flow space signal measurements corresponding to the family of sequence reads, determining a consensus sequence alignment for each family of sequence reads, wherein a portion of the consensus sequence alignments correspond to the consensus sequence reads aligned with the targeted fusion reference sequence, generating a compressed data structure comprising consensus compressed data, the consensus compressed data including the consensus sequence read and the consensus sequence alignment for each family, and detecting a fusion using the consensus sequence reads and the consensus sequence alignments from the compressed data structure.

    MARKERS CAPABLE OF DISTINGUISHING CELL PLURIPOTENCY AND USES THEREOF
    260.
    发明申请
    MARKERS CAPABLE OF DISTINGUISHING CELL PLURIPOTENCY AND USES THEREOF 审中-公开

    公开(公告)号：US20190064164A1

    公开(公告)日：2019-02-28

    申请号：US16047504

    申请日：2018-07-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Uma LAKSHMIPATHY ,  Rene QUINTANILLA ,  Joanna ASPRER

    IPC: G01N33/569 ,  C12N5/0775 ,  C12N5/077 ,  C12N5/00

    Abstract: Provided herein are compositions, methods and uses that relate to or result from the identification of markers that can distinguish between cells at different stages of pluripotency. Certain embodiments provide markers that can distinguish between parental cells (i.e. differentiated cells), partially pluripotent (i.e. partially reprogrammed) and pluripotent (i.e. fully reprogrammed cells). Also provided here are uses of such differential markers, for example, in identification of cell potential, in diagnostics, in differential separation, and in creating efficient workflows that involve fewer steps and lesser time in identifying or separating a desired reprogrammed clone or cell line from a mixture of cells at various stages of pluripotency. In certain embodiments, the activity of these markers can be manipulated to influence cell potential for research or medical purposes.

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