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公开(公告)号：US12152235B2
公开(公告)日：2024-11-26
申请号：US18069171
申请日：2022-12-20
Applicant: LIFE TECHNOLOGIES AS
Inventor： Laure Jobert
IPC: C12N15/10
Abstract: This invention relates to methods and compositions for coupling nucleic acid to a functionalized surface or support. In particular, the present invention provides an improved process for coupling aminated nucleic acid to a support functionalized with carboxylic acid groups, wherein the coupling reaction is conducted in the presence of an organic solvent. The invention further relates to compositions and kits for performing the coupling reaction and uses of nucleic acid-loaded supports for various applications.
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公开(公告)号：US12122859B2
公开(公告)日：2024-10-22
申请号：US18101785
申请日：2023-01-26
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C07F7/18 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F130/08 , C08F220/58 , C08F222/38 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/414 , C08F220/60
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F222/385 , C08F230/085 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , C08F220/603 , C08F2800/20 , C08J2343/04 , Y10T428/2982 , C08F8/12 , C08F257/02 , C08F8/34 , C08F8/12 , C08F257/02 , C12Q1/686 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543 , C08F257/02 , C08F230/085 , C08F8/12 , C08F230/085 , C08F8/34 , C08F8/12 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F220/603 , C08F230/085 , C08F212/36 , C08F230/085 , C08F222/102
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20240101999A1
公开(公告)日：2024-03-28
申请号：US18235205
申请日：2023-08-17
Applicant: Thermo Fisher Scientific GENEART GmbH , LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas POEHMERER , Phillip KUHN , Frank NOTKA , Andreas ZEIDLER , Korbinian HEIL , Axel TREFZER , Geir FONNUM , Federico KATZEN , Kristian ANDERSSON , Xiquan LIANG
CPC classification number: C12N15/101 , B01L3/502761 , B03C5/026 , C25B3/29 , C25B9/70 , C25B11/04 , C25B15/02 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C2201/26
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US11572427B2
公开(公告)日：2023-02-07
申请号：US17165039
申请日：2021-02-02
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F220/60
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US11261480B2
公开(公告)日：2022-03-01
申请号：US16849833
申请日：2020-04-15
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren Ellis , Geir Fonnum , Nini Kjus
IPC: C12Q1/68 , C12N15/10 , C12Q1/6806
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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Patent Agency Ranking
公开(公告)号：US10407676B2
公开(公告)日：2019-09-10
申请号：US14964060
申请日：2015-12-09
Applicant: LIFE TECHNOLOGIES CORPORATION , THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS
Inventor： Thomas Poehmerer , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US10202473B2
公开(公告)日：2019-02-12
申请号：US15005420
申请日：2016-01-25
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09487603B2
公开(公告)日：2016-11-08
申请号：US14970241
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C08J9/20 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/68 , C12P19/34 , G01N27/414
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20160115524A1
公开(公告)日：2016-04-28
申请号：US13989782
申请日：2011-11-28
Applicant: Darren James Ellis , Geir Fonnum , Nini Hofslokken Kjus
Inventor： Darren James Ellis , Geir Fonnum , Nini Hofslokken Kjus
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
Abstract translation: 一种用于处理核酸的方法，其中所述核酸暴露于水性培养基，所述水性培养基包含足够比例的多元醇，用于所述核酸的至少一部分进入或保留在超溶液相中。 因此，多元醇可以用于将溶液中的核酸与固体支持物结合，或者将固体支持物上的核酸同时保持在载体上。 多元醇可以是例如C 2 -C 10链烷二醇。
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公开(公告)号：US09243085B2
公开(公告)日：2016-01-26
申请号：US13762941
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Modahl , Nini Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F2/16 , C08F230/08 , C08F8/34 , C08F6/24 , C07F7/18 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F222/38 , C08F8/32 , C12Q1/68
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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