公开(公告)号：US12044921B2

公开(公告)日：2024-07-23

申请号：US18008520

申请日：2020-06-10

Applicant: Agency for Science, Technology and Research

Inventor： Shampy Mansha ,  Ramon Jose Paniagua Dominguez ,  Arseniy Kuznetsov

IPC: G02F1/1335

CPC classification number: G02F1/133553 ,  G02F1/133567 ,  G02F2203/12

Abstract: A spatial light modulator and a method for forming the spatial light modulator. The spatial light modulator may include a first reflector. The spatial light modulator may also include a second reflector. The spatial light modulator may further include a liquid crystal layer between the first reflector and the second reflector. The first reflector may include a first electrode. The second reflector may include a second electrode. At least one reflector selected from the first reflector and the second reflector may be or may include a distributed Bragg reflector (DBR). The first reflector and the second reflector may form a Fabry-Perot (FP) cavity.

公开(公告)号：US12036236B2

公开(公告)日：2024-07-16

申请号：US17507170

申请日：2021-10-21

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Nathaniel H. Park ,  Victoria A. Piunova ,  Zhi Xiang Voo

IPC: A61K31/765 ,  A61K31/155 ,  C08K5/31 ,  C08L69/00

CPC classification number: A61K31/765 ,  A61K31/155 ,  C08K5/31 ,  C08L69/00

Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.

公开(公告)号：US20240217170A1

公开(公告)日：2024-07-04

申请号：US18557509

申请日：2022-04-27

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Weijie Cyrus BEH

IPC: B29C64/124 ,  B29C64/112 ,  B29C64/209 ,  B29C64/264 ,  B29C64/336 ,  B29C64/40 ,  B33Y10/00 ,  B33Y30/00

CPC classification number: B29C64/124 ,  B29C64/112 ,  B29C64/209 ,  B29C64/264 ,  B29C64/336 ,  B29C64/40 ,  B33Y10/00 ,  B33Y30/00

Abstract: There is provided a multimodality method and a system for printing a three-dimensional (3D) construct or part thereof, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be crosslinked through irradiation by an irradiation source; (ii) depositing one or more materials on/within the flowable precursor; and (iii) crosslinking through irradiation by the irradiation source, at least part of the flowable precursor that is in contact with the one or more materials in the flowable precursor to form the 3D construct or part thereof.

公开(公告)号：US20240160222A1

公开(公告)日：2024-05-16

申请号：US18279922

申请日：2022-03-02

Applicant: Agency for Science, Technology and Research

Inventor： Saurab VERMA ,  Syed Zeezhan Ahmed MUKHTAR ,  Kun ZHANG ,  Nicolas Andre GAUTHIER ,  Kam Pheng NG ,  Yuda CHEN ,  Chong Boon TAN ,  Albertus Hendrawan ADIWAHONO

IPC: G05D1/246 ,  G01S17/89 ,  G05D105/80 ,  G05D111/10 ,  G05D111/63 ,  G06T7/579 ,  G06T7/70

CPC classification number: G05D1/246 ,  G01S17/89 ,  G06T7/579 ,  G06T7/70 ,  G05D2105/87 ,  G05D2111/17 ,  G05D2111/65 ,  G06T2207/10028

Abstract: A method of localizing a mobile robot 100 with respect to a target object 601 using an initial map of a reference object which is a representation of the target object is disclosed herein. The method comprises obtaining LiDAR data 503 of the target object 601 captured by a LiDAR device 203 of the mobile robot 100 as the mobile robot 100 traverses in an environment associated with the target object 601 the LiDAR data including respective point cloud representations of the target object 501 and the environment in various sampling instances; iteratively updating pose data representing estimated pose of the mobile robot 100 with respect to a known reference location in corresponding sampling instances as the mobile robot traverses the environment; extracting a subset of LiDAR data points in the point cloud representation of a previous sampling instance, the subset of LiDAR data points corresponding to features of the target object 601 in the initial map based on the estimated pose of the mobile robot 100 associated with the previous sampling instance; obtaining desired LiDAR data points in the point cloud representation in a current sampling instance, the desired LiDAR data points including current LiDAR data points which correspond to the extracted subset of LiDAR data points in the previous sampling instance; and determining a localization pose of the mobile robot 100 with respect to the target object 601 in the current sampling instance based on the desired LiDAR data points. A system for localizing a mobile robot is also disclosed herein.

公开(公告)号：US20240148728A1

公开(公告)日：2024-05-09

申请号：US18547670

申请日：2022-02-23

Applicant: Nanyang Technological University ,  Agency for Science, Technology and Research

Inventor： Lei ZHONG ,  Kim Samirah ROBINSON ,  Gee Ann TOH ,  Zijin SUN

IPC: A61K31/506 ,  A61K31/365 ,  A61K31/428 ,  A61K31/519 ,  A61K31/69 ,  A61K35/748 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61K31/365 ,  A61K31/428 ,  A61K31/519 ,  A61K31/69 ,  A61K35/748 ,  A61P35/00

Abstract: The present invention is directed to a method of modulating inflammation and/or related complications triggered by ZAKα kinase-activated NLRP1-driven pyroptosis; a compound or composition comprising said compound for use in the method, and use of said compounds in medicament preparation. More particularly, the inflammation is caused by a ribotoxin or UVB irradiation. Inhibition of said ZAKα kinase-activated NLRP1-driven pyroptosis may be used in the prophylaxis or treatment of human airway or skin inflammation and/or related complications, whereas activation of ZAKα kinase-activated NLRP1-driven pyroptosis may be used in the prophylaxis or treatment of cancer.

公开(公告)号：US20240137001A1

公开(公告)日：2024-04-25

申请号：US18548275

申请日：2021-03-21

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Sagnik GHOSH ,  Eldwin Jiaqiang NG ,  Jaibir SHARMA ,  Srinivas MERUGU

IPC: H03H9/13 ,  H03H3/02 ,  H03H9/17

CPC classification number: H03H9/13 ,  H03H3/02 ,  H03H9/17

Abstract: Various embodiments may relate to a resonator. The resonator may include a support including a substrate portion, and a membrane portion extending from the substrate portion over a cavity. The resonator may also include a piezoelectric layer on the membrane portion. The resonator may further include an electrode on the piezoelectric layer. The substrate portion may include dopants of a first conductivity type. The membrane portion may include dopants of a second conductivity type different from the first conductivity type. A ratio of a thickness of the membrane portion to a combined thickness of the electrode and the piezoelectric layer may be above 3:1 for temperature compensation.

公开(公告)号：US20240134197A1

公开(公告)日：2024-04-25

申请号：US18278974

申请日：2022-02-25

Applicant: Agency for Science, Technology and Research ,  Nanyang Technological University

Inventor： Weitao Song ,  Xinan Liang ,  Yuanjin Zheng ,  Arseniy Kuznetsov

IPC: G02B27/01

CPC classification number: G02B27/0172 ,  G02B27/0179 ,  G02B2027/0127 ,  G02B2027/0174 ,  G02B2027/0187

Abstract: An optical system and a method of forming the same. The optical system may include a light source configured to generate a light beam, the light beam being coherent or partially coherent. The optical system may also include a spatial light modulator configured to modulate a phase of the light beam. The optical system may further include an eyepiece for directing the modulated light beam to an eye of a viewer, the eyepiece arranged such that an optical distance between the spatial light modulator and a main plane of the eyepiece is greater than a focal length of the eyepiece. The spatial light modulator may include an active display area having a dimension of less than 2 mm.

公开(公告)号：US11960051B2

公开(公告)日：2024-04-16

申请号：US17292124

申请日：2019-10-14

Applicant: Agency for Science, Technology and Research

Inventor： Shiyang Zhu ,  Chih-Kuo Tseng ,  Ting Hu ,  Zhengji Xu ,  Yuan Dong ,  Alex Yuandong Gu

IPC: G02B1/00 ,  G02B1/02

CPC classification number: G02B1/002 ,  G02B1/02

Abstract: Various embodiments may provide a method of fabricating a meta-lens structure. The method may include forming a first dielectric layer in contact with a silicon wafer. The method may also include forming a second dielectric layer in contact with the first dielectric layer. A refractive index of the second dielectric layer may be different from a refractive index of the first dielectric layer. The method may further include, in patterning the second dielectric layer. The method may additionally include removing at least a portion of the silicon wafer to expose the first dielectric layer.

公开(公告)号：US20240117023A1

公开(公告)日：2024-04-11

申请号：US18356305

申请日：2023-07-21

Applicant: Agency for Science, Technology and Research ,  Tan Tock Seng Hospital Pte Ltd

Inventor： Frederic Bard ,  Le Son Tran ,  Khai Pang Leong ,  Joanne Zhi Hui Chia

IPC: C07K16/18 ,  A61P19/02

CPC classification number: C07K16/18 ,  A61P19/02 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Disclosed herein are methods and treatments for cartilage degradation, wherein the method comprises administration of a therapeutic agent which inhibits the Ga1N Ac-T activation (GALA) pathway.

公开(公告)号：US20240110241A1

公开(公告)日：2024-04-04

申请号：US18256303

申请日：2021-12-07

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Lai Guan Ng ,  Shu Feng Melissa Ng ,  De Li Leonard Tan ,  Florent Benoit Claude Ginhoux

IPC: C12Q1/6881

CPC classification number: C12Q1/6881 ,  C12Q2600/158 ,  G01N2800/52 ,  G01N2800/56

Abstract: The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.