公开(公告)号：US20180177746A1

公开(公告)日：2018-06-28

申请号：US15672031

申请日：2017-08-08

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas L. Little, Jr. ,  Anna Gall ,  Feng Hong

IPC: A61K31/137 ,  C07C309/06 ,  A61K31/222 ,  A61K31/165 ,  C07C323/33 ,  C07C215/20 ,  C07D309/06 ,  C07D277/24 ,  C07C323/25 ,  C07C317/28 ,  C07C279/08 ,  C07C251/86 ,  C07C235/08 ,  C07C233/18 ,  C07C229/38 ,  C07C225/16 ,  C07C217/72 ,  C07C217/64 ,  C07C217/62 ,  C07C217/60 ,  C07C217/20 ,  C07C217/84

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US09957224B2

公开(公告)日：2018-05-01

申请号：US13887243

申请日：2013-05-03

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik ,  Susan Hayes Henry ,  Ryo Kubota ,  Vladimir A. Kuksa

IPC: A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C215/08 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

CPC classification number: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US09737496B2

公开(公告)日：2017-08-22

申请号：US15260127

申请日：2016-09-08

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas L. Little, Jr. ,  Anna Gall ,  Feng Hong

IPC: C09B11/02 ,  A61K31/137 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06 ,  C07C215/20 ,  C07C309/06 ,  C07C217/84 ,  C07C323/33 ,  A61K31/165 ,  A61K31/222

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20160151369A1

公开(公告)日：2016-06-02

申请号：US14776675

申请日：2014-03-11

Applicant: ACUCELA INC.

Inventor： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC: A61K31/505 ,  A61K31/4409 ,  A61K31/4406 ,  A61K31/4465 ,  A61K31/445 ,  A61K31/44 ,  A61K31/343 ,  A61K31/341 ,  A61K31/351 ,  A61K31/382

CPC classification number: C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US09133154B2

公开(公告)日：2015-09-15

申请号：US14205117

申请日：2014-03-11

Applicant: Acucela Inc.

Inventor： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC: C07D309/06 ,  C07D213/38 ,  C07D335/02 ,  C07D211/26 ,  C07D211/76 ,  C07D307/81 ,  C07D307/14 ,  C07D279/02 ,  C07D311/58 ,  C07D207/09 ,  C07D239/26 ,  C07D333/20 ,  C07D209/14

CPC classification number: C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20140323530A1

公开(公告)日：2014-10-30

申请号：US14226665

申请日：2014-03-26

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Thomas L. Little ,  Ryo Kubota

IPC: C07D335/02 ,  C07D309/06 ,  C07D213/38 ,  C07D333/20 ,  C07C215/20 ,  C07C217/74

CPC classification number: A61K31/382 ,  A61K31/138 ,  A61K31/165 ,  A61K31/351 ,  C07C211/27 ,  C07C213/00 ,  C07C215/20 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/72 ,  C07C217/74 ,  C07C219/22 ,  C07C225/16 ,  C07C225/18 ,  C07C233/18 ,  C07C235/34 ,  C07C235/54 ,  C07C237/20 ,  C07C237/38 ,  C07C237/40 ,  C07C257/14 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D213/30 ,  C07D213/38 ,  C07D309/06 ,  C07D333/16 ,  C07D333/20 ,  C07D335/02

Abstract: Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Abstract translation: 提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和失调症的方法，例如年龄相关性黄斑变性和Stargardt氏病。

公开(公告)号：US20140213617A1

公开(公告)日：2014-07-31

申请号：US14162672

申请日：2014-01-23

Applicant: ACUCELA INC.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Jennifer Gage ,  Feng Hong

IPC: C07D335/02 ,  C07D309/12 ,  C07C235/34 ,  C07C211/27 ,  C07C215/30 ,  C07C217/48 ,  C07C215/42 ,  C07D213/38 ,  C07C217/64

CPC classification number: C07C215/68 ,  C07C211/27 ,  C07C211/30 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/14 ,  C07C217/48 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C235/34 ,  C07C237/20 ,  C07C251/40 ,  C07C255/58 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C323/36 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/32 ,  C07D213/14 ,  C07D213/38 ,  C07D309/06 ,  C07D309/10 ,  C07D309/12 ,  C07D333/06 ,  C07D333/16 ,  C07D335/02

Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Abstract translation: 提供炔基苯基衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和疾病如老年性黄斑变性和Stargardt氏病的方法。

公开(公告)号：US12210225B2

公开(公告)日：2025-01-28

申请号：US18160200

申请日：2023-01-26

Applicant: ACUCELA INC.

Inventor： Beat Wyss ,  Jean-Noel Fehr ,  Glenn Noronha ,  Karim Haroud ,  Julien Sauvet ,  Hans Bernhard ,  Christian Oggenfuss ,  Amitava Gupta ,  Ryo Kubota

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US12162871B2

公开(公告)日：2024-12-10

申请号：US18201715

申请日：2023-05-24

Applicant: Acucela Inc.

Inventor： Mark W. Orme ,  Edison S. Zuniga ,  Vladimir A. Kuksa ,  Russell Stuart Craft ,  Eduardo Moreno Saveedra ,  Johannes Wilhelm Georg Meissner ,  Jacobus Antonius Joseph den Hartog ,  Albert Cornelis Dros

IPC: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US12029708B2

公开(公告)日：2024-07-09

申请号：US17817927

申请日：2022-08-05

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas L Little, Jr. ,  Anna Gall ,  Feng Hong

IPC: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07D277/24 ,  C07D309/06

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07D277/24 ,  C07D309/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.