公开(公告)号：US11813124B2

公开(公告)日：2023-11-14

申请号：US17838883

申请日：2022-06-13

Applicant: Board of Regents of the University of Nebraska

Inventor： Mark Reichenbach ,  Shane Farritor

IPC: A61B90/50 ,  A61B17/02 ,  A61B1/00 ,  A61B34/00 ,  A61B34/30 ,  A61B17/00

CPC classification number: A61B90/50 ,  A61B1/00149 ,  A61B17/0206 ,  A61B34/30 ,  A61B34/73 ,  A61B2017/00477 ,  A61B2034/302 ,  A61B2218/002 ,  A61B2218/007

Abstract: Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.

公开(公告)号：US20230270599A1

公开(公告)日：2023-08-31

申请号：US18096682

申请日：2023-01-13

Applicant: Board of Regents of the University of Nebraska

Inventor： Jingwei Xie ,  Mark Carlson ,  Shixuan Chen ,  Alec McCarthy

IPC: A61F13/38 ,  A61B10/00 ,  A61L15/32 ,  A61L15/40 ,  A61L15/60

CPC classification number: A61F13/385 ,  A61B10/0051 ,  A61L15/32 ,  A61L15/40 ,  A61L15/60 ,  A61L2400/12

Abstract: Nanofiber swabs are provided as well as methods of use thereof and methods of making.

公开(公告)号：US11738116B2

公开(公告)日：2023-08-29

申请号：US16611415

申请日：2018-06-08

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Jingwei Xie ,  Shixuan Chen ,  Mark Carlson

IPC: A61L27/38 ,  A61L2/00 ,  A61L27/22 ,  A61L27/54 ,  A61L27/60 ,  D01D1/02 ,  D01D5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: A61L27/3834 ,  A61L2/0005 ,  A61L27/222 ,  A61L27/54 ,  A61L27/60 ,  D01D1/02 ,  D01D5/003 ,  A61L2202/21 ,  A61L2300/232 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/12 ,  B82Y30/00 ,  B82Y40/00

Abstract: Expanded, nanofiber structures comprising electrospun nanofibers, a plurality of holes, and, optionally, cells are provided. Methods of making the nanofiber structures as well as methods of use thereof, particularly for wound healing, are also provided.

公开(公告)号：US20230200909A1

公开(公告)日：2023-06-29

申请号：US18145951

申请日：2022-12-23

Applicant: Board of Regents of the University of Nebraska

Inventor： Hani Haider ,  Osvaldo Andres Barrera

IPC: A61B34/10 ,  A61B17/14 ,  A61B90/00 ,  A61B34/20 ,  A61B34/30 ,  A61B90/11 ,  A61B17/15 ,  A61B17/16 ,  A61B17/17

CPC classification number: A61B34/10 ,  A61B17/15 ,  A61B17/142 ,  A61B17/154 ,  A61B17/1675 ,  A61B17/1703 ,  A61B17/1764 ,  A61B34/20 ,  A61B34/30 ,  A61B90/11 ,  A61B90/36 ,  A61B2034/101 ,  A61B2034/102 ,  A61B2034/104 ,  A61B2034/254 ,  A61B2034/2055 ,  A61B2034/2068

Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.

公开(公告)号：US11679075B2

公开(公告)日：2023-06-20

申请号：US16911070

申请日：2020-06-24

Applicant: Board of Regents of the University of Nebraska

Inventor： Irving H. Zucker ,  Hanjun Wang

IPC: A61K31/357 ,  A61K9/00

CPC classification number: A61K9/0019 ,  A61K9/0085 ,  A61K31/357

Abstract: There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.

公开(公告)号：US20230133174A1

公开(公告)日：2023-05-04

申请号：US17883195

申请日：2022-08-08

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Siavash Jafarzadeh ,  Florin Bobaru ,  Adam Larios

IPC: G06F30/20 ,  G06F17/14

Abstract: In accordance with some embodiments, systems, methods, and media for efficient peridynamic modeling with bounded domains are provided. In some embodiments, a method comprises: receiving a plurality of parameters associated with a non-local model that has a convolutional structure to be used for one or more simulations, wherein the plurality of parameters includes a shape of a domain Ω, a horizon size δ, and one or more boundary constraints; drawing a periodic box that includes the domain Ω and a boundary layer Γ extending from the domain Ω; imposing the one or more boundary constraints on the boundary layer Γ; performing a simulation of a physical process using the non-local model and convolutional properties of Fourier transforms; and causing a result of the simulation to be presented.

公开(公告)号：US20230092901A1

公开(公告)日：2023-03-23

申请号：US18058904

申请日：2022-11-28

Applicant: Board of Regents of the University of Nebraska

Inventor： Jack Mondry ,  Shane Farritor ,  Eric Markvicka ,  Thomas Frederick ,  Joe Bartels

IPC: A61B34/30 ,  B25J9/00 ,  A61B90/00 ,  A61B34/20 ,  A61B17/00

Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.

公开(公告)号：US20230075784A1

公开(公告)日：2023-03-09

申请号：US17793013

申请日：2021-01-15

Applicant: Board of Regents of the University of Nebraska

Inventor： Geoffrey M. Thiele ,  Amar Singh ,  Michael J. Duryee ,  Rizwan Ahmad

IPC: G01N33/564

Abstract: In various embodiments methods of distinguishing Crohn's disease from ulcerative colitis are provided. In certain embodiments the methods comprise determining, or causing to be determined, the level of IgG antibodies that bind a malondialdehyde-acetaldehyde adduct (MAA adduct) in a biological sample from a mammal, where an elevated level of said antibodies as compared to the average level found in a mammal with Crohn's disease is an indicator that the mammal has ulcerative colitis rather than Crohn's disease.

公开(公告)号：US11564745B2

公开(公告)日：2023-01-31

申请号：US17399969

申请日：2021-08-11

Applicant: Board of Regents of the University of Nebraska

Inventor： Hani Haider ,  Osvaldo Andres Barrera

IPC: A61B34/10 ,  A61B17/14 ,  A61B90/00 ,  A61B34/20 ,  A61B34/30 ,  A61B90/11 ,  A61B17/15 ,  A61B17/16 ,  A61B17/17 ,  A61B34/00 ,  A61B90/90 ,  A61B17/00 ,  A61B17/32 ,  A61F2/46

Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.

公开(公告)号：US11542341B2

公开(公告)日：2023-01-03

申请号：US16782015

申请日：2020-02-04

Applicant: Board of Regents of the University of Nebraska

Inventor： Geoffrey M. Thiele ,  Daniel R. Anderson ,  Michael J. Duryee

IPC: C07K16/42 ,  C07K14/47 ,  G01N33/564 ,  G01N33/68 ,  A61P9/10 ,  C07K16/06 ,  C07K16/18 ,  A61K49/00 ,  G01N33/53

Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde acetaldehyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.