中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

28 records (took 0.028 seconds)

    Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    22.
    发明申请
    Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 审中-公开
    使用组织荧光测定糖化终产物或疾病状态的测量

    公开(公告)号：US20120065484A1

    公开(公告)日：2012-03-15

    申请号：US13292321

    申请日：2011-11-09

    Applicant: Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

    Inventor： Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

    IPC: A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

    Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise various light excitation and detection configurations. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method.

    Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括各种光激发和检测配置。 本发明还可以包括校正技术，其减少由于检测除了组织中的化学物质的荧光以外的光的测定误差。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适用于实施该方法的装置。

    Determination of a measure of a glycation end-product or disease state using tissue fluorescence
    23.
    发明授权
    Determination of a measure of a glycation end-product or disease state using tissue fluorescence 有权
    使用组织荧光测定糖基化终产物或疾病状态的量度

    公开(公告)号：US08078243B2

    公开(公告)日：2011-12-13

    申请号：US11561380

    申请日：2006-11-17

    Applicant: Marwood Neal Ediger ,  John D Maynard ,  Robert D Johnson ,  Edward L Hull ,  Christopher D Brown

    Inventor： Marwood Neal Ediger ,  John D Maynard ,  Robert D Johnson ,  Edward L Hull ,  Christopher D Brown

    IPC: A61B5/1455

    CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

    Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

    Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

    HANDHELD INFRARED AND RAMAN MEASUREMENT DEVICES AND METHODS
    25.
    发明申请
    HANDHELD INFRARED AND RAMAN MEASUREMENT DEVICES AND METHODS 有权
    手持式红外和拉曼测量装置和方法

    公开(公告)号：US20100133437A1

    公开(公告)日：2010-06-03

    申请号：US12691047

    申请日：2010-01-21

    Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

    Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

    IPC: G01J3/44 ,  G01J5/02

    CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

    Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

    Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。

    Handheld infrared and Raman measurement devices and methods
    26.
    发明授权
    Handheld infrared and Raman measurement devices and methods 有权
    手持式红外和拉曼测量装置及方法

    公开(公告)号：US07675611B2

    公开(公告)日：2010-03-09

    申请号：US11864304

    申请日：2007-09-28

    Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

    Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

    IPC: G01N21/35 ,  G01N21/65

    CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

    Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

    Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的来自所述源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。

    Spectrum searching method that uses non-chemical qualities of the measurement
    27.
    发明授权
    Spectrum searching method that uses non-chemical qualities of the measurement 有权
    使用非化学品质测量的频谱搜索方法

    公开(公告)号：US07254501B1

    公开(公告)日：2007-08-07

    申请号：US11119147

    申请日：2005-04-30

    Applicant: Christopher D. Brown ,  Gregory H. Vander Rhodes

    Inventor： Christopher D. Brown ,  Gregory H. Vander Rhodes

    IPC: G01R23/16 ,  G01B3/00

    CPC classification number: G01N21/359 ,  G01J3/28 ,  G01N21/3577 ,  G01N21/65

    Abstract: A method for determining the most likely composition of a sample, including obtaining data from a sample, wherein the data includes a representation of a measured spectrum; determining the precision state of the representation of the measured spectrum; providing a plurality of library candidates and, for each library candidate, providing data representing each library candidate, wherein the data includes a representation of a library spectrum; determining a representation of the similarity of the sample to each library candidate using (i) the representation of the measured spectrum; (ii) the precision state of the representation of the measured spectrum; and (iii) the representation of the library spectrum for that library candidate; determining the most likely composition of the sample based upon the determined representations of similarity of the sample to each library candidate; and displaying the most likely composition of the sample to a user.

    Abstract translation: 一种用于确定样本的最可能组成的方法，包括从样本获得数据，其中所述数据包括测量光谱的表示; 确定测量光谱表示的精度状态; 提供多个库候选，并且对于每个库候选者，提供表示每个库候选的数据，其中所述数据包括库频谱的表示; 使用（i）所述测量的谱的表示来确定所述样本与每个库候选的相似性的表示; （ii）测量光谱表示的精确状态; 及（iii）该图书馆候选人的图书馆频谱表示; 基于所确定的样本与每个库候选者的相似度的表示来确定样本的最可能的组合; 并向用户显示最可能的样本组成。

    Determination of a measure of a glycation end-product or disease state using tissue fluorescence
    28.
    发明授权
    Determination of a measure of a glycation end-product or disease state using tissue fluorescence 有权
    使用组织荧光测定糖基化终产物或疾病状态的量度

    公开(公告)号：US07139598B2

    公开(公告)日：2006-11-21

    申请号：US10972173

    申请日：2004-10-22

    Applicant: Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

    Inventor： Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

    IPC: A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

    Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

    Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

Patent Agency Ranking