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    OPTICAL MEASUREMENT OF SAMPLES
    3.
    发明申请
    OPTICAL MEASUREMENT OF SAMPLES 有权
    样品的光学测量

    公开(公告)号：US20080291426A1

    公开(公告)日：2008-11-27

    申请号：US11864304

    申请日：2007-09-28

    Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

    Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang

    IPC: G01J3/00 ,  G01B9/02 ,  G01N21/00 ,  G01N21/47

    CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N2021/3595

    Abstract: We disclose apparatus that includes: (a) an enclosure including an aperture; (b) a prism mounted in the enclosure so that a surface of the prism is exposed through the aperture; (c) an optical assembly contained within the enclosure, the optical assembly including a radiation source and a radiation detector, the source being configured to direct radiation towards the prism and the detector being configured to detect radiation from the source reflected from the exposed surface of the prism; and (d) an electronic processor contained within the enclosure, the electronic processor being in communication with the detector. The apparatus can be configured so that, during operation, the electronic processor determines information about a sample placed in contact with the exposed surface of the prism based on radiation reflected from the exposed prism surface while it is in contact with the sample.

    Abstract translation: 我们公开了包括以下设备：（a）包括孔的外壳; （b）安装在外壳中的棱镜，使得棱镜的表面通过该孔露出; （c）包含在所述外壳内的光学组件，所述光学组件包括辐射源和辐射探测器，所述源被配置成将辐射引向所述棱镜，并且所述检测器被配置为检测来自所述源的反射的源的辐射， 棱镜; 以及（d）包含在所述外壳内的电子处理器，所述电子处理器与所述检测器通信。 该装置可以被配置为使得在操作期间，电子处理器在与样品接触的同时基于从暴露的棱镜表面反射的辐射来确定关于与棱镜的暴露表面接触的样品的信息。

    Determination of a measure of a glycation end-product or disease state using tissue fluorescence preferentially from the dermis
    5.
    发明授权
    Determination of a measure of a glycation end-product or disease state using tissue fluorescence preferentially from the dermis 有权
    使用优先来自真皮的组织荧光测定糖基化终产物或疾病状态的量度

    公开(公告)号：US08121671B2

    公开(公告)日：2012-02-21

    申请号：US11417463

    申请日：2006-05-03

    Applicant: Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

    Inventor： Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

    IPC: A61B5/00 ,  A61B5/1455

    CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

    Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

    Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

    SPECTRUM SEARCHING METHOD THAT USES NON-CHEMICAL QUALITIES OF THE MEASUREMENT
    7.
    发明申请
    SPECTRUM SEARCHING METHOD THAT USES NON-CHEMICAL QUALITIES OF THE MEASUREMENT 审中-公开
    采用非化学性质测量的谱搜索方法

    公开(公告)号：US20110257918A1

    公开(公告)日：2011-10-20

    申请号：US13087725

    申请日：2011-04-15

    Applicant: Christopher D. Brown ,  Gregory H. Vander Rhodes

    Inventor： Christopher D. Brown ,  Gregory H. Vander Rhodes

    IPC: G01R23/16

    CPC classification number: G01N21/359 ,  G01J3/28 ,  G01N21/3577 ,  G01N21/65

    Abstract: Methods and systems for determining information about a sample are disclosed. The methods can include measuring spectral information for a sample and determining a quantity related to a signal-to-noise ratio for the spectral information, repeating the measuring and determining until a value of the quantity is beyond a threshold value, and comparing the spectral information to reference information to determine information about the sample.

    Abstract translation: 公开了用于确定关于样品的信息的方法和系统。 所述方法可以包括测量样本的光谱信息并且确定与所述光谱信息的信噪比相关的量，重复所述测量和确定，直到所述量的值超过阈值，并且将所述光谱信息 以参考信息来确定关于样本的信息。

    Methods and systems for determining sample identity information are disclosed
    8.
    发明授权
    Methods and systems for determining sample identity information are disclosed 有权
    使用非化学品质测量的频谱搜索方法

    公开(公告)号：US07698080B2

    公开(公告)日：2010-04-13

    申请号：US11890780

    申请日：2007-08-07

    Applicant: Christopher D. Brown ,  Gregory H. Vander Rhodes

    Inventor： Christopher D. Brown ,  Gregory H. Vander Rhodes

    IPC: G01N31/00 ,  G01R23/16

    CPC classification number: G01N21/359 ,  G01J3/28 ,  G01N21/3577 ,  G01N21/65

    Abstract: Methods for determining the most likely composition of sample are disclosed. The methods can include: obtaining data from a sample, where the data includes a representation of a measured spectrum; determining a precision state of the representation of the measured spectrum; providing a plurality of library candidates; for each library candidate, providing data representing each library candidate, where the data includes a representation of a library spectrum; determining a representation of the similarity of the sample to each library candidate; determining the most likely composition of the sample based upon the determined representations of similarity of the sample to each library candidate; and displaying the most likely composition of the sample to a user.

    Abstract translation: 公开了确定样品组成最可能的方法。 该方法可以包括：从样本获得数据，其中数据包括测量光谱的表示; 确定测量光谱的表示的精度状态; 提供多个图书馆候选人; 对于每个库候选者，提供表示每个库候选的数据，其中数据包括库频谱的表示; 确定样本与每个图书馆候选人的相似性的表示; 基于所确定的样本与每个库候选者的相似度的表示来确定样本的最可能的组合; 并向用户显示最可能的样本组成。

    Adaptive compensation for measurement distortions in spectroscopy
    10.
    发明授权
    Adaptive compensation for measurement distortions in spectroscopy 失效
    光谱测量失真的自适应补偿

    公开(公告)号：US07092832B2

    公开(公告)日：2006-08-15

    申请号：US10733195

    申请日：2003-12-11

    Applicant: Christopher D. Brown

    Inventor： Christopher D. Brown

    IPC: G01D18/00

    CPC classification number: G01J3/28 ,  G01N21/274

    Abstract: Methods of reducing the effects of measurement device artifacts on a measurement of a sample are presented. A number of reference measurements performed with the measurement device are observed to identify reference independent components of the reference measurements. The variations of the reference independent components are used as surrogates for possible artifacts of the measurement device. A number of measurements of subjects similar to the sample are observed, and similarity components of the subject measurements that vary in a manner similar to the reference independent components may be identified. The sample measurement is then adjusted to remove at least part of the similarity components that correspond to the variations in the reference independent components. The adjustment of the sample measurement is thereby improved by reducing the effects of artifacts of the measurement device.

    Abstract translation: 提出了减少测量装置伪影对样品测量的影响的方法。 观察使用测量装置进行的许多参考测量来识别参考测量的参考独立分量。 参考独立分量的变化被用作测量装置的可能伪影的代理。 观察到类似于样品的受试者的多个测量，并且可以以类似于参考独立成分的方式来识别受试者测量的相似性分量。 然后调整样品测量以去除与参考独立组分的变化相对应的至少部分相似性成分。 从而通过减少测量装置的伪影的影响来提高样本测量的调整。

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