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公开(公告)号：US20110195133A1
公开(公告)日：2011-08-11
申请号：US12703102
申请日：2010-02-09
Applicant: Chung-Hsuan Chen , Wei-Chao Chang , Michael Hsiao , Ming-Shyan Huang , Chih-Jen Yang
Inventor： Chung-Hsuan Chen , Wei-Chao Chang , Michael Hsiao , Ming-Shyan Huang , Chih-Jen Yang
IPC: A61K33/24 , C07K7/06 , A61K31/7088 , A61P35/00 , C12Q1/00
CPC classification number: C07K14/4723 , A61K31/7088 , A61K33/24 , A61K38/04 , A61K45/06 , G01N30/72 , G01N33/57423 , G01N33/57488 , G01N33/6851 , A61K2300/00
Abstract: Methods for diagnosis of non-small cell lung cancers by detection of endogenous peptides in exhaled breath condensate (EBC) are provided. Diagnostic peptides derived from dermcidin (DCD) are provided. A specific dermcidin-derived peptide E-R11, having the sequence ENAGEDPGLAR, is provided. E-R11 peptide levels in EBC, as measured by mass spectrometry (MS), are highly diagnostic of non-small cell lung cancers. A method for inhibiting growth of lung cancer cells by inhibiting DCD expression by RNA interference also is provided.
Abstract translation: 提供了通过检测呼出气体浓缩物（EBC）中的内源肽来诊断非小细胞肺癌的方法。 提供衍生自皮肤霉素（DCD）的诊断肽。 提供具有ENAGEDPGLAR序列的具体的皮肤霉素衍生肽E-R11。 通过质谱（MS）测量，EBC中的E-R11肽水平是非小细胞肺癌的高度诊断。 还提供了通过RNA干扰抑制DCD表达来抑制肺癌细胞生长的方法。
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公开(公告)号：US20100276582A1
公开(公告)日：2010-11-04
申请号：US12431896
申请日：2009-04-29
Applicant: Chung Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
Inventor： Chung Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
CPC classification number: H05H5/047 , H01J49/06 , H01J49/40 , H01J49/403
Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.
Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。
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公开(公告)号：US5184015A
公开(公告)日：1993-02-02
申请号：US766542
申请日：1991-09-27
Applicant: Steve L. Allman , Chung-Hsuan Chen , Fang C. Chen
Inventor： Steve L. Allman , Chung-Hsuan Chen , Fang C. Chen
IPC: G01N27/64
CPC classification number: G01N27/622
Abstract: A method for analyzing a gaseous electronegative species comprises the steps of providing an analysis chamber; providing an electric field of known potential within the analysis chamber; admitting into the analysis chamber a gaseous sample containing the gaseous electronegative species; providing a pulse of free electrons within the electric field so that the pulse of free electrons interacts with the gaseous electronegative species so that a swarm of electrically charged particles is produced within the electric field; and, measuring the mobility of the electrically charged particles within the electric field.
Abstract translation: 用于分析气体电负性物质的方法包括提供分析室的步骤; 在分析室内提供已知电位的电场; 进入分析室中含有气态电负性物质的气态样品; 在电场内提供自由电子脉冲，使得自由电子的脉冲与气体电负性物质相互作用，从而在电场内产生带电粒子群; 并测量电场内的带电粒子的迁移率。
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公开(公告)号：US08153964B2
公开(公告)日：2012-04-10
申请号：US12457064
申请日：2009-05-29
Applicant: Chung-Hsuan Chen , Chen-I Wu
Inventor： Chung-Hsuan Chen , Chen-I Wu
IPC: H01J49/26
CPC classification number: H01J49/10 , H01J49/0454
Abstract: Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, including biological macromolecules and nanoparticles, can be achieved. Ionization efficiency can be improved by addition of chemicals such as, for example, organic solvents or acids to the sample.
Abstract translation: 提供了超声电离质谱法的方法和系统。 样品中的分析物通过对其进行超声波离子化，便于通过质谱法进行分析。 通过这些方法和系统，可以实现大分子的软电离，包括生物大分子和纳米颗粒。 通过向样品中加入化学物质，例如有机溶剂或酸，可以提高电离效率。
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公开(公告)号：US08138472B2
公开(公告)日：2012-03-20
申请号：US12431896
申请日：2009-04-29
Applicant: Chung Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
Inventor： Chung Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
IPC: H01J49/40
CPC classification number: H05H5/047 , H01J49/06 , H01J49/40 , H01J49/403
Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.
Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。
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Patent Agency Ranking
公开(公告)号：US20110284733A1
公开(公告)日：2011-11-24
申请号：US12785945
申请日：2010-05-24
Applicant: Chung-Hsuan Chen , Chien-Hsun Chen , Jung-Lee Lin , Ming Lee Chu
Inventor： Chung-Hsuan Chen , Chien-Hsun Chen , Jung-Lee Lin , Ming Lee Chu
CPC classification number: H01J49/025 , H01J49/0027
Abstract: A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP.
Abstract translation: 质谱仪和在质谱仪中获得单个大分子或生物分子离子的质谱的方法。 该方法包括通过大分子或生物分子的离子化在离子阱中产生单个大分子或生物分子一级离子; 用第一电荷检测器喷射一半的初级离子用于检测; 喷射一半的初级离子以冲击转换倍增极，从而产生二次离子，以便用电荷放大检测器（例如通道电极或电倍增管或MCP）进行检测。
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公开(公告)号：US20110147581A1
公开(公告)日：2011-06-23
申请号：US12976543
申请日：2010-12-22
Applicant: Chung-Hsuan Chen , Jung-Lee Lin , Ming-Lee Chu
Inventor： Chung-Hsuan Chen , Jung-Lee Lin , Ming-Lee Chu
IPC: H01J49/26
CPC classification number: H01J49/0022 , H01J49/424 , H01J49/429
Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.
Abstract translation: 公开了便携式质谱法的方法和装置。 该装置包括至少一个离子化分析物源，至少一个频率扫描子系统，至少一个检测器和可选的至少一个真空泵，并且是便携式的。 在一些实施方案中，装置包括多个电离分析物源和/或配置成获得大分析物的质谱，例如m / z比至少为105的分析物，或分子量至少为105的分析物 Da，以及小分子分析物的质谱。 在一些实施例中，所述方法包括使用上述便携式装置获得质谱。
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公开(公告)号：US20100301199A1
公开(公告)日：2010-12-02
申请号：US12457064
申请日：2009-05-29
Applicant: Chung-Hsuan Chen , Chen-I Wu
Inventor： Chung-Hsuan Chen , Chen-I Wu
CPC classification number: H01J49/10 , H01J49/0454
Abstract: Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, including biological macromolecules and nanoparticles, can be achieved. Ionization efficiency can be improved by addition of chemicals such as, for example, organic solvents or acids to the sample.
Abstract translation: 提供了超声电离质谱法的方法和系统。 样品中的分析物通过对其进行超声波离子化，便于通过质谱法进行分析。 通过这些方法和系统，可以实现大分子的软电离，包括生物大分子和纳米颗粒。 通过向样品中加入化学物质，例如有机溶剂或酸，可以提高电离效率。
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公开(公告)号：US07645987B2
公开(公告)日：2010-01-12
申请号：US11234051
申请日：2005-09-22
Applicant: Huan-Cheng Chang , Chung-Hsuan Chen
Inventor： Huan-Cheng Chang , Chung-Hsuan Chen
CPC classification number: H01J49/16 , H01J49/0454
Abstract: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.
Abstract translation: 一种生产气相分子的方法包括提供分子样品，该样品的特征在于电荷分布，并引导分子样品上的声辐射以从样品解吸至少一些分子，使得解吸的分子具有 电荷分布基本上与分子样品的电荷分布相同。
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公开(公告)号：US20090189069A1
公开(公告)日：2009-07-30
申请号：US12314520
申请日：2008-12-11
Applicant: Chung Hsuan Chen , Wen-Ping Peng , Ming Lee Chu , Huan Cheng Chang , Huan-Chang Lin
Inventor： Chung Hsuan Chen , Wen-Ping Peng , Ming Lee Chu , Huan Cheng Chang , Huan-Chang Lin
CPC classification number: H01J49/4265 , H01J49/0077 , H01J49/025
Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
Abstract translation: 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。
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