公开(公告)号：US20100168611A1

公开(公告)日：2010-07-01

申请号：US12663923

申请日：2008-07-13

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B10/02 ,  A61B5/00 ,  A61B17/3205

CPC classification number: A61B10/0233 ,  A61B5/00 ,  A61B10/0266 ,  A61B90/37 ,  A61B2017/00022 ,  A61B2017/00128 ,  A61B2017/00199 ,  A61B2018/1475 ,  A61B2090/061

Abstract: A medical device is presented for use in tissue characterization and treatment. The device comprises: a tissue characterization probe comprising an elongated carrier carrying an array of tissue characterization sensors arranged in a spaced-apart relationship at least along an axis of said carrier, such that progression of the probe through a tissue mass provides for locating and determining a dimension of an abnormal tissue specimen inside said tissue mass based on characterization signals from the sensors in the array, thereby enabling consequent treatment of the abnormal tissue specimen by a treatment tool.

Abstract translation: 呈现用于组织表征和治疗的医疗装置。 所述装置包括：组织表征探针，其包括细长载体，所述细长载体承载至少沿着所述载体的轴线以间隔关系布置的组织表征传感器阵列，使得所述探针通过组织块的进展提供定位和确定 基于来自阵列中的传感器的特征信号，所述组织块内的异常组织标本的尺寸，从而能够通过治疗工具对异常组织标本进行治疗。

公开(公告)号：US20080214953A1

公开(公告)日：2008-09-04

申请号：US11712529

申请日：2007-03-01

Applicant: Dan Hashimshony ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/00

CPC classification number: A61B5/0059 ,  A61B5/0064 ,  A61B5/05 ,  A61B5/6834

Abstract: A measurement system and method are provided for use in characterizing a tissue. The system comprises a probe adapted for operating in either a scan mode or a measure mode, and a control unit for operating the probe. The probe comprises a sensing module for measuring one or more parameters indicative of one or more states of the tissue; and an attachment module configured and operable to enable selective operation of the probe in either one of the scan mode and the measure modes. The control unit is configured and operative to selectively operate the probe in either one of the scan and measure modes.

Abstract translation: 提供了用于表征组织的测量系统和方法。 该系统包括适于以扫描模式或测量模式操作的探针和用于操作探针的控制单元。 探针包括用于测量指示组织的一个或多个状态的一个或多个参数的感测模块; 以及附件模块，其配置和可操作以使得能够以所述扫描模式和所述测量模式中的任一个选择性地操作所述探针。 控制单元被配置和操作以选择性地在扫描和测量模式中的任何一个中操作探针。

公开(公告)号：US20080154090A1

公开(公告)日：2008-06-26

申请号：US10567581

申请日：2006-01-04

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B1/018 ,  A61M25/09

CPC classification number: A61B1/018

Abstract: An endoscopic system for in-vivo tissue characterization, using a nonirradiative electromagnetic sensor, is described. The endoscopic system is further configured to employ several follow-up procedures, for example, biopsy sampling, localized surgery, dispensing a medicament, and the like, so that on the whole, the endoscopic system provides for the early detection of cancerous and pre-cancerous tissue, in vivo, and for the application of immediate follow-up procedures to any such tissue.

Abstract translation: 描述了使用非辐射电磁传感器进行体内组织表征的内窥镜系统。 内窥镜系统还被配置为采用几个后续程序，例如活组织检查取样，局部手术，分配药物等，使得整体上，内窥镜系统提供癌症和预先检测的早期检测， 癌组织，体内，以及对任何这样的组织应用立即随访。

公开(公告)号：US20080021343A1

公开(公告)日：2008-01-24

申请号：US11797167

申请日：2007-05-01

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/053

CPC classification number: A61B5/053 ,  A61B5/0538 ,  A61B5/415 ,  A61B5/418 ,  A61B10/0041 ,  A61B17/320016 ,  A61B17/320783 ,  A61B2017/00026

Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.

Abstract translation: 本发明涉及用于通过其介电特性进行组织表征的探针，系统和方法，其中探针的物理特征被设计成在组织边缘处限定和限定组织体积，其中进行表征。 因此，用于组织边缘表征的探针包括：第一内部导体，其包括：沿x轴的相对于组织边缘的近端和远端; 固有地与近端相关联的第一锋利边缘; 至少一个特征，从第一内部导体发出，基本上在近端处，用于形成至少一个额外的锋利边缘，用于在组织边缘处的通常预定的组织体积内增强组织中的局部电气条纹区域， 组织体积通常由与至少一个特征相关联的物理参数限定; 以及在y-z平面中包围导体的电介质材料。

公开(公告)号：US20070179397A1

公开(公告)日：2007-08-02

申请号：US11705143

申请日：2007-02-12

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05

CPC classification number: A61B5/053 ,  A61B5/415 ,  A61B5/418

Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.

Abstract translation: 本发明涉及用于通过其介电特性进行组织表征的探针，系统和方法，其中探针的物理特征被设计成在组织边缘处限定和限定组织体积，其中进行表征。 因此，用于组织边缘表征的探针包括：第一内部导体，其包括：沿x轴的相对于组织边缘的近端和远端; 固有地与近端相关联的第一锋利边缘; 至少一个特征，从第一内部导体发出，基本上在近端处，用于形成至少一个额外的锋利边缘，用于在组织边缘处的通常预定的组织体积内增强组织中的局部电气条纹区域， 组织体积通常由与至少一个特征相关联的物理参数限定; 以及在y-z平面中包围导体的电介质材料。

公开(公告)号：US20070032739A1

公开(公告)日：2007-02-08

申请号：US11196732

申请日：2005-08-04

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/00

CPC classification number: A61B5/4381 ,  A61B5/6834

Abstract: A device and method for tissue characterization are provided, the device comprising: a structure; a first mechanism, associated with said structure, configured for exerting a first force on a tissue, for fixing the tissue to said structure, so as to substantially immobilize the tissue; and a second mechanism, associated with said structure, configured for pressing a sensor against an external surface of the immobilized tissue, thereby exerting a second force on the immobilized tissue, wherein at least a component of said first force is in opposition to at least a component of said second force, forcing the immobilized tissue against said sensor, and forcing said sensor against the immobilized tissue, bringing about an effective contact between said sensor and the immobilized tissue.

Abstract translation: 提供了用于组织表征的装置和方法，所述装置包括：结构; 与所述结构相关联的第一机构被配置为在组织上施加第一力，用于将组织固定到所述结构，以便基本上固定所述组织; 以及与所述结构相关联的第二机构，其配置成将传感器压靠在固定化组织的外表面上，从而对固定化组织施加第二力，其中所述第一力的至少一部分与至少一个 所述第二力的分量，强制所述固定化组织抵靠所述传感器，并迫使所述传感器抵靠所述固定的组织，从而在所述传感器和所述固定的组织之间产生有效的接触。

公开(公告)号：US20060253107A1

公开(公告)日：2006-11-09

申请号：US10558831

申请日：2005-03-23

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B17/00 ,  A61B18/18 ,  A61B8/00 ,  A61B5/103 ,  A61B5/117

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/01 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/055 ,  A61B5/06 ,  A61B5/4312 ,  A61B8/0858 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B18/082 ,  A61B34/20 ,  A61B2017/00026 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/061 ,  A61B2090/367 ,  A61B2090/378

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。

公开(公告)号：US06486685B1

公开(公告)日：2002-11-26

申请号：US09554915

申请日：2000-09-08

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: G01R3126

CPC classification number: G01R27/06 ,  G01R31/308

Abstract: Apparatus and method for measuring surface resistivity of a wafer (12). A source of high frequency radiation (6, 41) emits an incident wave burst that impinges the wafer at a desired spot location. A reflected wave burst is detected at an appropriate time window by a receiver (8, 42). The relationship between incident and reflected energies is a function of the surface resistivity of the wafer.

Abstract translation: 用于测量晶片（12）的表面电阻率的装置和方法。 高频辐射源（6,41）发射入射波纹，其将晶片撞击到期望的光点位置。 在适当的时间窗口处由接收器（8,42）检测到反射波阵发。 入射和反射能量之间的关系是晶片的表面电阻率的函数。

公开(公告)号：US09526460B2

公开(公告)日：2016-12-27

申请号：US13337183

申请日：2011-12-26

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61B5/01 ,  A61B5/053 ,  A61B5/055 ,  A61B5/103 ,  A61B8/13

CPC classification number: A61B6/032 ,  A61B5/0059 ,  A61B5/015 ,  A61B5/0536 ,  A61B5/055 ,  A61B5/103 ,  A61B5/4312 ,  A61B5/6834 ,  A61B5/6843 ,  A61B5/6844 ,  A61B5/6885 ,  A61B5/6886 ,  A61B6/4417 ,  A61B6/5247 ,  A61B8/13

Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.

Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，其上布置有至少一个传感器，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。

公开(公告)号：US09226979B2

公开(公告)日：2016-01-05

申请号：US13485412

申请日：2012-05-31

Applicant: Dan Hashimshony

Inventor： Dan Hashimshony

IPC: A61B5/00 ,  A61K49/00 ,  A61B5/053 ,  A61B5/06

CPC classification number: A61K49/00 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/0538 ,  A61B5/065 ,  A61B5/411 ,  A61B5/416 ,  Y10S607/901

Abstract: A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.