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21.发明授权Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor 失效用于治疗与血管内皮生长因子受体水平相关的疾病或病症的方法和试剂公开(公告)号：US06566127B1
公开(公告)日：2003-05-20
申请号：US09371772
申请日：1999-08-10
IPC分类号： C12N500
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The present invention relates to nucleic acid molecules which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor.
摘要翻译： 本发明涉及调节编码血管内皮生长因子的一种或多种受体的mRNA的合成，表达和/或稳定性的核酸分子。
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公开(公告)号：US6106841A
公开(公告)日：2000-08-22
申请号：US18798
申请日：1998-02-04
申请人： Jorge E. Osorio , Dan T. Stinchcomb
发明人： Jorge E. Osorio , Dan T. Stinchcomb
IPC分类号： A61K39/00 , A61K39/205 , A61K48/00 , A61P31/00 , A61P37/04 , A61K39/12 , A61K39/275
CPC分类号： A61K39/00 , A61K39/12 , A61K39/205 , A61K2039/53 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K48/00 , C12N2710/24143 , C12N2760/20134
摘要： The present invention relates to a novel method to immunize an animal against a heterologous antigen. The method includes the step of administering to the animal, by an intranasal route, a conjunctival route, or a combination thereof, a composition comprising a recombinant raccoon poxvirus having a nucleic acid molecule encoding such a heterologous antigen. Animals to be immunized include those that are susceptible to such routes of recombinant raccoon poxvirus administration. Preferred animals to immunize include felids. Preferably, any immune response generated by the animal against viral antigens of the recombinant raccoon poxvirus is sufficiently small so as to not prevent the animal from eliciting an immune response to a heterologous antigen encoded by a recombinant raccoon poxvirus subsequently administered to the animal.
摘要翻译： 本发明涉及一种针对异源抗原免疫动物的新方法。 该方法包括向动物，鼻内途径，结膜途径或其组合施用包含具有编码异源抗原的核酸分子的重组浣熊痘病毒的组合物的步骤。 要免疫的动物包括对这种重组浣熊痘病毒施用途径敏感的动物。 优选的免疫动物包括猫科动物。 优选地，由动物针对重组浣熊痘病毒的病毒抗原产生的任何免疫应答足够小，从而不能防止动物对随后施用于动物的重组浣熊痘病毒编码的异源抗原引发免疫应答。
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公开(公告)号：US5612215A
公开(公告)日：1997-03-18
申请号：US390850
申请日：1995-02-17
IPC分类号： A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/47 , C12N9/64 , C12N15/113 , C12N15/85 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , C12Y304/24017 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.
摘要翻译： 一种酶切RNA分子，其切割与发育或维持关节炎病症相关的mRNA。
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公开(公告)号：US5599706A
公开(公告)日：1997-02-04
申请号：US311760
申请日：1994-09-23
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/85 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122
摘要： Enzymatic RNA molecules which cleave apo(a) mRNA.
摘要翻译： 切割apo（a）mRNA的酶RNA分子。
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25.发明申请COMPOSITIONS, METHODS AND USES FOR EXPRESSION OF ENTEROBACTERIUM-ASSOCIATED PEPTIDES 审中-公开组合物，用于表达肠壁菌相关肽的方法和用途公开(公告)号：US20150343046A1
公开(公告)日：2015-12-03
申请号：US14679944
申请日：2015-04-06
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达肠细菌相关肽的方法，组合物和用途。 在一些实施方案中，肠细菌相关肽包括但不限于瘟疫相关肽。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于表达肠细菌相关肽的减毒或修饰的痘苗病毒载体。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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公开(公告)号：US20140302091A1
公开(公告)日：2014-10-09
申请号：US13300217
申请日：2011-11-18
CPC分类号： A61K39/12 , A61K47/26 , A61K47/36 , A61K47/42 , A61K2039/5254 , A61K2039/55555 , A61K2039/70 , C08G2650/58 , C08L71/02 , C08L2203/02 , C12N7/00 , C12N2710/10051 , C12N2710/10061 , C12N2710/24151 , C12N2710/24161 , C12N2760/16051 , C12N2760/16061 , C12N2760/18411 , C12N2770/24134 , C12N2770/24151 , C12N2770/24161 , C12N2770/36151 , C12N2770/36161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Embodiments herein relate to compositions of and methods for live viruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated viruses and compositions to reduce inactivation and/or degradation of the live, attenuated virus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated virus composition may include at least one carbohydrate, at least one protein and at least one high molecular weight surfactants for reducing inactivation and/or degradation of the live, attenuated virus.
摘要翻译： 本文的实施方案涉及活病毒的组合物和方法。 在某些实施方案中，活的减毒病毒组合物包括但不限于一种或多种活的，减毒的病毒和组合物，以减少活的，减毒的病毒的失活和/或降解。 在其它实施方案中，活的减毒病毒组合物可以是疫苗组合物。 在其它组合物中，活的减毒病毒组合物可包括至少一种碳水化合物，至少一种蛋白质和至少一种用于减少活的，减毒病毒的失活和/或降解的高分子量表面活性剂。
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公开(公告)号：US20130209513A1
公开(公告)日：2013-08-15
申请号：US13555026
申请日：2012-07-20
IPC分类号： C12N15/863
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions having two or more influenza gene segments. In other embodiments, vaccine compositions are reported of use in a subject.
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公开(公告)号：US20130136767A1
公开(公告)日：2013-05-30
申请号：US13510601
申请日：2010-11-22
IPC分类号： C12N15/863 , A61K39/145 , A61K39/00
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24134 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions. In other embodiments, vaccine compositions are reported of use in a subject.
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公开(公告)号：US20130034583A1
公开(公告)日：2013-02-07
申请号：US13511652
申请日：2010-11-24
IPC分类号： C12N15/63 , A61P37/04 , A61K39/275
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
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公开(公告)号：US20100144015A1
公开(公告)日：2010-06-10
申请号：US12631629
申请日：2009-12-04
CPC分类号： C12N7/00 , C12N2770/24134 , C12N2770/24151
摘要： Embodiments herein report methods, compositions and uses for inducing and/or accelerating viral growth. In certain embodiments, methods, compositions and uses generally related to copolymer compositions for inducing viral growth, reducing lag time and/or increasing viral plaque size. In other embodiments, methods, compositions and uses of copolymer compositions can be for inducing flaviviral growth, reducing lag in growth and/or increasing plaque size.
摘要翻译： 本文的实施方案报告用于诱导和/或加速病毒生长的方法，组合物和用途。 在某些实施方案中，方法，组合物和用途通常涉及用于诱导病毒生长，减少滞后时间和/或增加病毒斑块大小的共聚物组合物。 在其它实施方案中，共聚物组合物的方法，组合物和用途可用于诱导黄病毒生长，减少生长滞后和/或增加斑块大小。
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