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公开(公告)号：US08268996B2
公开(公告)日：2012-09-18
申请号：US13161555
申请日：2011-06-16
Applicant: Hong Liu , David C. Tully , Arnab Chatterjee , Phillip B. Alper , David H. Woodmansee , Daniel Mutnick
Inventor： Hong Liu , David C. Tully , Arnab Chatterjee , Phillip B. Alper , David H. Woodmansee , Daniel Mutnick
IPC: C07D413/12 , C07D295/185 , A61K31/5377 , A61K31/5375
CPC classification number: C07D263/56 , C07D211/66 , C07D273/02 , C07D277/64 , C07D295/185 , C07D307/30
Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与组织蛋白酶S活性相关的疾病或病症的方法。
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公开(公告)号：US20090270409A1
公开(公告)日：2009-10-29
申请号：US12204600
申请日：2008-09-04
Applicant: Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
Inventor： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC: A61K31/497 , C07D401/02 , C07D409/14 , C07D241/04
CPC classification number: C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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公开(公告)号：US07501408B2
公开(公告)日：2009-03-10
申请号：US11932679
申请日：2007-10-31
Applicant: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
Inventor： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC: C07D417/12 , C07D295/10 , A61K31/541
CPC classification number: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula (I): wherein Q is thiomorpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
Abstract translation: 本发明提供了用于选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供具有式（I）的化合物：其中Q是硫代吗啉基; A，R5，R6，R7，R8，R9和Ar为取代基。
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Patent Agency Ranking
公开(公告)号：US20080194668A1
公开(公告)日：2008-08-14
申请号：US12063350
申请日：2006-08-15
Applicant: Thomas Marsilje , Wenshuo Lu , Phil Alper , Daniel Mutnick , Yun He
Inventor： Thomas Marsilje , Wenshuo Lu , Phil Alper , Daniel Mutnick , Yun He
IPC: A61K31/404 , C07D209/04 , A61P7/00
CPC classification number: C07D209/14 , C07D209/18 , C07D235/18
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法，特别是涉及血小板减少症的疾病或病症。
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公开(公告)号：US20080108595A1
公开(公告)日：2008-05-08
申请号：US11932679
申请日：2007-10-31
Applicant: Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
Inventor： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
IPC: C07D413/00 , A61K31/535 , C07D265/30 , A61K31/5377 , A61K31/54 , C07D279/12 , C07D241/04 , A61K31/495 , A61K31/397 , C07D205/04
CPC classification number: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
Abstract translation: 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US07297714B2
公开(公告)日：2007-11-20
申请号：US10970344
申请日：2004-10-20
Applicant: Hong Liu , Phillip Alper , Daniel Mutnick , Donald Karanewsky
Inventor： Hong Liu , Phillip Alper , Daniel Mutnick , Donald Karanewsky
IPC: A61K31/4025 , A61K31/341 , A61K31/35 , A61K31/365 , C07D413/06 , C07D307/32
CPC classification number: C07D407/12 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D235/08 , C07D295/215 , C07D307/33 , C07D307/68 , C07D405/12
Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20050130959A1
公开(公告)日：2005-06-16
申请号：US10970344
申请日：2004-10-20
Applicant: Hong Liu , Phillip Alper , Daniel Mutnick , Donald Karanewsky
Inventor： Hong Liu , Phillip Alper , Daniel Mutnick , Donald Karanewsky
IPC: A61K20060101 , A61K31/34 , A61K31/4025 , A61K31/452 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D307/04 , C07D307/33 , C07D405/12 , C07D407/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D45/02
CPC classification number: C07D407/12 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D235/08 , C07D295/215 , C07D307/33 , C07D307/68 , C07D405/12
Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20050113356A1
公开(公告)日：2005-05-26
申请号：US10922515
申请日：2004-08-18
Applicant: Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
Inventor： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
IPC: A61K20060101 , A61K31/397 , A61K31/401 , A61K31/404 , A61K31/423 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/537 , A61K31/5375 , A61K31/54 , C07D209/04 , C07D209/08 , C07D261/14 , C07D265/30 , C07D295/13 , C07D295/18 , C07D295/20 , C07D411/12 , C07D413/12 , C07D417/12
CPC classification number: C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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