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公开(公告)号：US20080108595A1
公开(公告)日：2008-05-08
申请号：US11932679
申请日：2007-10-31
申请人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
IPC分类号： C07D413/00 , A61K31/535 , C07D265/30 , A61K31/5377 , A61K31/54 , C07D279/12 , C07D241/04 , A61K31/495 , A61K31/397 , C07D205/04
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US20050113356A1
公开(公告)日：2005-05-26
申请号：US10922515
申请日：2004-08-18
申请人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
IPC分类号： A61K20060101 , A61K31/397 , A61K31/401 , A61K31/404 , A61K31/423 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/537 , A61K31/5375 , A61K31/54 , C07D209/04 , C07D209/08 , C07D261/14 , C07D265/30 , C07D295/13 , C07D295/18 , C07D295/20 , C07D411/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20080242671A1
公开(公告)日：2008-10-02
申请号：US12055154
申请日：2008-03-25
申请人： Hong Liu , Phillip Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
发明人： Hong Liu , Phillip Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
IPC分类号： A61K31/501 , A61K31/165 , C07C233/63 , A61K31/454 , C07D401/12 , C07D209/04 , A61K31/404 , C07D401/14
CPC分类号： C07D405/12 , C07C237/22 , C07C237/24 , C07C257/18 , C07C311/19 , C07C311/29 , C07C2601/14 , C07D207/12 , C07D207/24 , C07D209/08 , C07D209/42 , C07D211/60 , C07D213/71 , C07D231/14 , C07D257/04 , C07D261/18 , C07D271/10 , C07D307/20 , C07D307/24 , C07D307/68 , C07D309/08 , C07D311/22 , C07D333/40 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20070232606A1
公开(公告)日：2007-10-04
申请号：US11568459
申请日：2005-04-29
申请人： Hong Liu , David Tully , Arnab Chatterjee , Phillip Alper , David Woodmansee , Daniel Mutnick
发明人： Hong Liu , David Tully , Arnab Chatterjee , Phillip Alper , David Woodmansee , Daniel Mutnick
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D263/56 , C07D211/66 , C07D273/02 , C07D277/64 , C07D295/185 , C07D307/30
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与组织蛋白酶S活性相关的疾病或病症的方法。
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公开(公告)号：US07384970B2
公开(公告)日：2008-06-10
申请号：US10807613
申请日：2004-03-23
申请人： Hong Liu , Phil Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
发明人： Hong Liu , Phil Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
IPC分类号： A61K31/4045 , C07D209/08
CPC分类号： C07D405/12 , C07C237/22 , C07C237/24 , C07C257/18 , C07C311/19 , C07C311/29 , C07C2601/14 , C07D207/12 , C07D207/24 , C07D209/08 , C07D209/42 , C07D211/60 , C07D213/71 , C07D231/14 , C07D257/04 , C07D261/18 , C07D271/10 , C07D307/20 , C07D307/24 , C07D307/68 , C07D309/08 , C07D311/22 , C07D333/40 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US07109243B2
公开(公告)日：2006-09-19
申请号：US10807612
申请日：2004-03-23
申请人： Hong Liu , David Tully , Robert Epple , Badry Bursulaya , Jennifer Williams , Arnab Chatterjee , Jennifer Leslie Harris , Jun Li
发明人： Hong Liu , David Tully , Robert Epple , Badry Bursulaya , Jennifer Williams , Arnab Chatterjee , Jennifer Leslie Harris , Jun Li
IPC分类号： A01N47/28
CPC分类号： C07D307/68 , C07C237/14 , C07C237/20 , C07C255/57 , C07C275/28 , C07C275/30 , C07C275/42 , C07C2601/14 , C07D213/56 , C07D213/64 , C07D237/24 , C07D239/52 , C07D277/56 , C07D333/38
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供用于选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶（例如cathespin K）的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US20070123523A1
公开(公告)日：2007-05-31
申请号：US11620608
申请日：2007-01-05
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/165 , A61K31/54 , A61K31/497 , A61K31/445
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20050049244A1
公开(公告)日：2005-03-03
申请号：US10868459
申请日：2004-06-10
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K20060101 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/47 , A61K31/495 , A61K31/4965 , A61K31/537 , A61K31/54 , C07D277/82 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US07307095B2
公开(公告)日：2007-12-11
申请号：US11620608
申请日：2007-01-05
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/423 , A61K31/403 , A61K31/428
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US07173051B2
公开(公告)日：2007-02-06
申请号：US10868459
申请日：2004-06-10
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/423 , A61K31/403 , A61K31/428 , C07D263/58 , C07D227/04 , C07D417/02 , C07D498/02
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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