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公开(公告)号：US4608343A
公开(公告)日：1986-08-26
申请号：US739334
申请日：1985-05-30
Applicant: David P. Labeda , Joseph J. Goodman , Donald B. Borders , Raymond T. Testa , John H. E. J. Martin, deceased
Inventor： David P. Labeda , Joseph J. Goodman , Donald B. Borders , Raymond T. Testa , John H. E. J. Martin, deceased
CPC classification number: C12P1/06
Abstract: This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
Abstract translation: 本公开描述了在受控条件下使用新型链霉菌属的新菌株在微生物发酵中产生的四种新的抗菌剂，称为LL-C08078α1，LL-C08078α2，LL-C08078α3和LL-C08078ββ 称为Streptomyces majorciensis Labeda，sp。 nov。及其突变体。 这些新的抗菌剂对各种微生物具有活性，因此可用于抑制这些细菌的生长。 此外，这些试剂在温血动物中作为生长促进剂是有活性的。
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公开(公告)号：US4551533A
公开(公告)日：1985-11-05
申请号：US593160
申请日：1984-03-26
Applicant: Taikwang M. Lee , Donald B. Borders , Joseph J. Goodman , Raymond T. Testa , William M. Maiese , David P. Labeda
Inventor： Taikwang M. Lee , Donald B. Borders , Joseph J. Goodman , Raymond T. Testa , William M. Maiese , David P. Labeda
IPC: A23K20/195 , C07D491/16 , C12P17/18 , C07D521/00 , C12N1/20 , C12R1/03
CPC classification number: C07D491/16 , A23K20/195 , C12P17/188 , C12R1/03 , Y10S435/825
Abstract: Antibiotic LL-D42067.alpha. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
Abstract translation: 抗生素LL-D42067α是通过有氧发酵的微生物Actinomadura madurae亚种simaoensis NRRL 15734得到的，可用作抗菌和抗寄生虫剂。
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23.发明授权Antibacterial antibiotics LL-CO8078.alpha..sub.1, .alpha..sub.2, .alpha..sub.3 and .beta. 失效抗菌抗生素LL-CO8078 alpha 1，α2，α3和β
公开(公告)号：US4534970A
公开(公告)日：1985-08-13
申请号：US507184
申请日：1983-06-23
Applicant: David P. Labeda , Joseph J. Goodman , Donald B. Borders , Raymond T. Testa , John H. E. J. Martin, deceased
Inventor： David P. Labeda , Joseph J. Goodman , Donald B. Borders , Raymond T. Testa , John H. E. J. Martin, deceased
CPC classification number: C12P1/06
Abstract: This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
Abstract translation: 本公开描述了在受控条件下使用新型链霉菌属的新菌株在微生物发酵中产生的四种新的抗菌剂，称为LL-CO8078α1，LL-CO8078α2，LL-CO8078α3和LL-CO8078β 称为Streptomyces majorciensis Labeda，sp。 nov。及其突变体。 这些新的抗菌剂对各种微生物具有活性，因此可用于抑制这些细菌的生长。 此外，这些试剂在温血动物中作为生长促进剂是有活性的。
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24.再颁专利Antibacterial antibiotics AM31.alpha., AM31.beta. and AM31.gamma. 失效抗菌抗生素AM31 {60，AM31 {62 {0和AM31 {
公开(公告)号：USRE29903E
公开(公告)日：1979-02-06
申请号：US770481
申请日：1977-02-22
Applicant: Jane P. Kirby , Donald B. Borders
Inventor： Jane P. Kirby , Donald B. Borders
Abstract: This disclosure describes a novel class of antibiotics, three of which have been designed AM31.alpha., AM31.beta., and AM31.gamma. and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netropsis.
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公开(公告)号：US08889826B2
公开(公告)日：2014-11-18
申请号：US11630847
申请日：2005-07-01
Applicant: Richard A. Leese , Noreen Francis , William V. Curran , Donald B. Borders , Howard Jarolmen
Inventor： Richard A. Leese , Noreen Francis , William V. Curran , Donald B. Borders , Howard Jarolmen
CPC classification number: C07K5/0815 , A61K38/00 , C07K5/06086 , C07K7/62 , C07K7/64 , Y02A50/473 , Y02P20/55
Abstract: Disclosed herein are novel peptides and protected peptides. These compounds can be derived from naturally occurring peptides, such as those selected from colistin, circulin A, polymyxin A, polymyxin B, polymyxin D, octapeptin B, octapeptin C, and [Ile7]polymyxin B1. Also disclosed are pharmaceutical compositions containing the new peptides, as well as methods for preparing the novel peptides and protected peptides.
Abstract translation: 本文公开了新型肽和保护肽。 这些化合物可以衍生自天然存在的肽，例如选自粘菌素，环状蛋白A，多粘菌素A，多粘菌素B，多粘菌素D，八肽蛋白B，八肽蛋白C和[Ile7]多粘菌素B1的肽。 还公开了含有新肽的药物组合物，以及制备新肽和保护肽的方法。
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Patent Agency Ranking
公开(公告)号：US06737403B2
公开(公告)日：2004-05-18
申请号：US09904352
申请日：2001-07-13
Applicant: Donald B Borders , William V Curran , Amedeo A Fantini , Noreen D Francis , Howard Jarolmen , Richard A Leese
Inventor： Donald B Borders , William V Curran , Amedeo A Fantini , Noreen D Francis , Howard Jarolmen , Richard A Leese
IPC: A61K3812
CPC classification number: C07K1/14 , A61K38/00 , C07K7/08 , C07K7/56 , C07K9/00 , C07K11/02 , C08L23/08 , C08L23/0869 , C08L51/06 , C08L2203/14 , C09K3/10 , C09K2003/1037 , C09K2200/06 , C09K2200/062 , C09K2200/0622 , C08L2666/04 , C08L2666/02
Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
Abstract translation: 本发明提供了拉沙曲霉素核心肽，拉斯马霉素核心肽衍生物，抗菌蓝鲸霉素衍生物，制备拉沙曲霉素核心肽的方法，制备蓝鲸霉素核心肽衍生物的方法，制备抗菌蓝鲸霉素衍生物的方法，抗微生物蓝鲸霉素衍生物的药物组合物，抑制微生物的方法 用于治疗和/或预防受试者微生物感染的生长和方法。
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27.发明授权
公开(公告)号：US5077277A
公开(公告)日：1991-12-31
申请号：US403232
申请日：1989-09-05
Applicant: Douglas W. Phillipson , Guy T. Carter , Donald B. Borders
Inventor： Douglas W. Phillipson , Guy T. Carter , Donald B. Borders
IPC: A61K31/70 , A61K31/7024 , A61K31/7048 , A61P31/04 , C07H7/02 , C07H13/04 , C07H15/26
Abstract: Derivatives of antibiotics derived from the microorganism Streptomyces lydicus subspecies tanzanius, referred to as antibiotics LL-E19020 alpha and beta, are produced by chemical reaction. The derivatives are also active antibiotics useful in the treatment of bacterial infections.
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公开(公告)号：US4845037A
公开(公告)日：1989-07-04
申请号：US891082
申请日：1986-07-31
Applicant: Taikwang M. Lee , Joseph J. Goodman , Michael Greenstein , Donald B. Borders
Inventor： Taikwang M. Lee , Joseph J. Goodman , Michael Greenstein , Donald B. Borders
IPC: C12N1/20 , A61K20060101 , A61K31/535 , A61K35/74 , A61P31/04 , A61P33/10 , C07G11/00 , C12N20060101 , C12N1/00 , C12N1/06 , C12N5/00 , C12N15/00 , C12P1/00 , C12P1/06 , C12P17/16 , C12P17/18 , C12R1/29
CPC classification number: C12R1/29 , Y10S435/867
Abstract: A biologically pure culture of Micromonospora purpureochromogenes ssp. Wuxiensis and its use in an aerobic fermentation process to produce the antibacterial and antiparasitic agent LL-D42067.alpha..
Abstract translation: 一种生物学纯培养的小单孢菌紫色荧光发生物 无锡植物及其在好氧发酵过程中的应用，产生抗菌和抗寄生虫剂LL-D42067α。
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公开(公告)号：US4774184A
公开(公告)日：1988-09-27
申请号：US765418
申请日：1985-08-14
Applicant: Taikwang M. Lee , Donald B. Borders , Joseph J. Goodman , Raymond T. Testa , William M. Maiese , David P. Labeda
Inventor： Taikwang M. Lee , Donald B. Borders , Joseph J. Goodman , Raymond T. Testa , William M. Maiese , David P. Labeda
IPC: A23K20/195 , C07D491/16 , C12P17/18 , C12P17/16 , C12N1/20 , C12R1/03
CPC classification number: C07D491/16 , A23K20/195 , C12P17/188 , C12R1/03 , Y10S435/825
Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.
Abstract translation: 本发明是通过发酵生产名为LL-D42067α的抗细菌剂和抗寄生虫剂的方法，用于从粗溶液中回收和浓缩的方法及其纯化方法。 本发明在其范围内包括抗生素的生物学纯培养。
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公开(公告)号：US4705688A
公开(公告)日：1987-11-10
申请号：US880230
申请日：1986-06-30
Applicant: Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
Inventor： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
CPC classification number: C12P1/06
Abstract: This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
Abstract translation: 本发明涉及衍生自微生物链霉菌属（Streptomyces lydicus subspecies tanzanius）NRRL 18036的抗生素LL-E19020α和LL-E19020ββ，其可用作抗菌剂。
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