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公开(公告)号：US20130209994A1
公开(公告)日：2013-08-15
申请号：US13733239
申请日：2013-01-03
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
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公开(公告)号：US11874281B2
公开(公告)日：2024-01-16
申请号：US17501143
申请日：2021-10-14
CPC分类号： G01N33/6803 , C12Q1/485 , G01N33/92 , C12Y207/01091 , C12Y207/11001 , G01N2405/08 , G01N2410/00 , G01N2440/14 , G01N2440/30
摘要： Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
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公开(公告)号：US11181528B2
公开(公告)日：2021-11-23
申请号：US16225669
申请日：2018-12-19
摘要： Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
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公开(公告)号：US10920265B2
公开(公告)日：2021-02-16
申请号：US16833816
申请日：2020-03-30
IPC分类号： C12Q1/34 , C07D311/16 , C07D493/10
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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公开(公告)号：US10197583B2
公开(公告)日：2019-02-05
申请号：US15484754
申请日：2017-04-11
发明人： Michael C. Mullenix , Robert Elliot Zipkin , Jeffrey Kroll Adams , Wayne Forrest Patton , James J. Donegan
摘要： Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective.
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公开(公告)号：US20170362641A1
公开(公告)日：2017-12-21
申请号：US15689120
申请日：2017-08-29
发明人： Elazar RABBANI , James J. Donegan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6813 , C12Q1/6844 , C12Q2565/525 , C12Q2565/501 , C12Q2531/143
摘要： This invention provides methods for characterizing the amounts of nucleic acids, including plus/minus determinations, the use of different constructs, the use of a library and a reference library. Expression may also be compared in two or more samples using the methods of this invention. Also provided are heterophasic arrays comprising labeled positive copies of nucleic acids hybridized to the array and labeled negative copies of nucleic acids hybridized to the array, in which the labeled positive copies are separately quantifiable from the labeled negative copies.
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公开(公告)号：US09771667B2
公开(公告)日：2017-09-26
申请号：US15285749
申请日：2016-10-05
IPC分类号： C40B40/06 , C07H21/00 , C12Q1/68 , C12N15/10 , B01J19/00 , C40B40/10 , G01N33/68 , C40B40/00
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
摘要： This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
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公开(公告)号：US20160280921A1
公开(公告)日：2016-09-29
申请号：US15156565
申请日：2016-05-17
发明人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlum , Anatoliy Balanda , Dee Shen
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
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公开(公告)号：US20160018390A1
公开(公告)日：2016-01-21
申请号：US14772098
申请日：2014-03-05
IPC分类号： G01N33/53
CPC分类号： G01N33/82 , G01N33/5308
摘要： The disclosure relates to methods for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid sample. The disclosure further relates to kits for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid, the procedure comprising the step of release of the vitamin D from the serum binding protein (DBP), capturing of the released analyte by a specific antibody and competitive assay of the captured vitamin D against a conjugate between the vitamin D and a tracer. The observed signal is inversely proportional to vitamin D concentration.
摘要翻译： 本公开涉及用于测量哺乳动物流体样品中25（OH）维生素D（250HD）水平的方法。 本公开还涉及用于测量哺乳动物流体中25（OH）维生素D（250HD）水平的试剂盒，该方法包括从血清结合蛋白（DBP）释放维生素D的步骤，通过 捕获的维生素D针对维生素D和示踪剂之间的缀合物的特异性抗体和竞争性测定。 观察到的信号与维生素D浓度成反比。
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公开(公告)号：US09097673B2
公开(公告)日：2015-08-04
申请号：US13864524
申请日：2013-04-17
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDR1, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.
摘要翻译： 本发明涉及细胞中的多药耐药性（MDR），以及某些呫吨化合物用于测定细胞耐药性的用途以及受试化合物对膜转运体MDR1，MRP和BCRP对细胞膜转运的影响。 描述和提供了用于进行这些测定和测量这些影响的方法和试剂盒。
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