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公开(公告)号：US07386937B2
公开(公告)日：2008-06-17
申请号：US11416497
申请日：2006-05-01
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.
摘要翻译： 提供制造生物传感器的方法。 该方法包括在基底上提供导电材料，并使用从基底的激光烧蚀部分地去除导电材料，使得小于90％的导电材料保留在基底上，并且由导电材料形成至少一个电极图案。 所述至少一个电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。
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22.发明授权公开(公告)号：US06294062B1
公开(公告)日：2001-09-25
申请号：US09330422
申请日：1999-05-28
IPC分类号： G02N2726
CPC分类号： C07F15/0026 , C07K5/101 , C07K7/02 , C07K7/06 , C07K9/001 , C07K14/805 , G01N27/3277 , G01N33/532 , G01N33/536 , G01N33/58 , G01N33/723 , G01N2333/805 , G01N2458/30 , Y10S436/805 , Y10S436/806 , Y10T436/105831
摘要： A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials differing by at least 50 millivolts. At least one of the redox reversible species comprises a liquid sample diffusible conjugate of a ligand analog of an analyte in the liquid sample and a redox reversible label. A predetermined amount of at least one specific binding partner for each analyte to be measured is combined with the sample and current flow is measured at first and second anodic and cathodic potentials and correlated with current flows for known concentrations of the respective diffusible redox reversible species. Diagnostic devices and kits, including such devices and the specified specific binding partner(s) and redox reversible species are also described.
摘要翻译： 描述了用于在液体样品中检测和定量生物学显着性分析物的方法和装置。 该方法包括使体积的液体样品与预定量的至少50毫伏的氧化还原电位的至少第一和第二氧化还原可逆物质接触。 至少一种氧化还原可逆物质包括液体样品中分析物的配体类似物和氧化还原可逆标记的液体样品可扩散共轭物。 将待测量的每种待测量分析物的至少一个特定结合配偶体的预定量与样品组合，并且在第一和第二阳极和阴极电位处测量电流，并且与已知浓度的各个可扩散的氧化还原可逆物质的电流相关。 还描述了诊断装置和试剂盒，包括这些装置和指定的特异性结合配偶体和氧化还原可逆物质。
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公开(公告)号：US06270637B1
公开(公告)日：2001-08-07
申请号：US09386210
申请日：1999-08-31
申请人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
发明人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
摘要翻译： 一种具有四个新特征的电化学生物传感器测试条。 测试条包括针对带样品应用端口的位置的触感的缩进。 样品应用端口通向包括测试试剂的毛细管测试室。 湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和 由测试用户进行机械操作。 毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行 测试。 测试条还可以包括位于样品应用端口处的凹口。 缺口减少了称为“剂量犹豫”的现象。
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公开(公告)号：US5437999A
公开(公告)日：1995-08-01
申请号：US200174
申请日：1994-02-22
IPC分类号： G01N27/28 , C12M1/40 , C12Q1/00 , C25B11/00 , G01N27/26 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/416 , G01N33/487 , C12M1/34
CPC分类号： C12Q1/001 , G01N27/3272 , Y10S435/817
摘要： A method for fabricating high-resolution, biocompatible electrodes is disclosed, allowing production of an electrochemical sensor which is capable of precise analyte concentration determination on a very small sample size. Electrically conducting material is affixed to a first insulating substrate. A second insulating substrate is then affixed to the electrically conducting material and patterned using photolithography to define an electrode area. Alternatively, the electrically conducting material may be screen printed directly onto a standard printed circuit board substrate in the case of a counter or reference electrode. In either case, the substrate may be rigid or flexible. When the electrodes produced in accordance with the present invention are then used in an electrochemical sensor which includes a reagent, the small and highly-defined electrode areas permit highly-accurate electrochemical analyte measurements to be performed on very small sample sizes.
摘要翻译： 公开了一种用于制造高分辨率生物相容性电极的方法，其允许生产能够在极小样品尺寸上精确分析物浓度测定的电化学传感器。 导电材料固定在第一绝缘基片上。 然后将第二绝缘基板固定到导电材料上，并使用光刻法图案化以限定电极区域。 或者，在计数器或参考电极的情况下，导电材料可以直接丝网印刷到标准印刷电路板基底上。 在任一情况下，衬底可以是刚性的或柔性的。 当根据本发明生产的电极然后用于包括试剂的电化学传感器中时，小且高度限定的电极区域允许在非常小的样品尺寸上进行高精度的电化学分析物测量。
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