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    Absorbing organic reagents into diagnostic test devices by formation of amine salt complexes
    21.
    发明授权
    Absorbing organic reagents into diagnostic test devices by formation of amine salt complexes 失效
    通过形成胺盐络合物将有机试剂吸收到诊断试验装置中

    公开(公告)号：US07563621B2

    公开(公告)日：2009-07-21

    申请号：US10506098

    申请日：2003-02-17

    Applicant: James A Profitt ,  Alexander H. Orn

    Inventor： James A Profitt ,  Alexander H. Orn

    IPC: G01N33/48

    CPC classification number: G01N33/54353 ,  G01N33/52

    Abstract: A method of applying an organic acid reagent having limited transolubility in organic solvents, aqueous solvents, and mixtures thereof to a component of a diagnostic test device by mixing an organic acid reagent and an amine to form a salt complex, dissolving the salt complex in a solvent to release the organic acid reagent into the solvent, and applying the solvent to the component of the diagnostic test device such that the organic acid reagent present in the solvent becomes integrated into the diagnostic test device. The amine is represented by the formula HmNRn wherein m is 0, 1, or 2; n is 1, 2, or 3; the sum of m and n is 3; and R is an independently selected group which renders the salt complex soluble in aqueous solvents, organic solvents, or mixtures thereof. The amine is also represented by the formula NR4+ wherein R is an independently selected group which renders the salt complex soluble in aqueous solvents, organic solvents, or mixtures thereof. The organic acid reagent is selected from a carboxylic acid, a sulfonic acid, a phosphoric acid, and mixtures thereof. Preferred reagents are dyes like pyragallol red. In a specific embodiment the diagnostic test device is a paper test strip.

    Abstract translation: 一种通过混合有机酸试剂和胺形成盐络合物，将有机溶剂在有机溶剂，含水溶剂及其混合物中的有机酸试剂施用于诊断试验装置的组分的方法，将盐络合物溶解在 溶剂将有机酸试剂释放到溶剂中，并将溶剂施加到诊断测试装置的组分，使得存在于溶剂中的有机酸试剂整合到诊断测试装置中。 胺由式HmNRn表示，其中m为0,1或2; n为1,2或3; m和n的和为3; 并且R是独立选择的基团，其使盐络合物可溶于含水溶剂，有机溶剂或其混合物中。 胺也由式NR4 +表示，其中R是独立选择的基团，其使盐络合物可溶于含水溶剂，有机溶剂或其混合物。 有机酸试剂选自羧酸，磺酸，磷酸及其混合物。 优选的试剂是如吡咯咯醇红的染料。 在具体实施例中，诊断测试装置是纸张测试条。

    Total protein detection methods and devices
    23.
    发明授权
    Total protein detection methods and devices 有权
    总蛋白检测方法和装置

    公开(公告)号：US06815210B1

    公开(公告)日：2004-11-09

    申请号：US10480314

    申请日：2003-12-11

    Applicant: James A. Profitt ,  Alexander H. Orn ,  Jennifer Farr

    Inventor： James A. Profitt ,  Alexander H. Orn ,  Jennifer Farr

    IPC: G01N2178

    CPC classification number: G01N33/6839 ,  G01N33/543

    Abstract: An assay for the determination of protein in an aqueous test fluid which combines the test fluid with a buffer and a dye. The buffer is selected from citrulline, malonic acid, cyanoacetic acid, citraconic acid, methyl phosphonic acid, sarcosine, saccharin, or combinations thereof. The buffer is added in sufficient quantity to maintain the pH of the assay including the test fluid at a selected target pH range within a range of from about 2.0 to about 3.0. The dye has a pKa which enables it to operate as a protein indicator at the target pH range. The dye also has affinity for protein such that it will provide a detectable response in the presence of greater than about 15 mg/dL protein to thereby render the assay suitable for the detection of total protein in the test fluid. The buffer and dye may be absorbed in a test strip of absorbent material.

    Abstract translation: 在测试流体与缓冲液和染料组合的水性测试流体中测定蛋白质的测定法。 缓冲液选自瓜氨酸，丙二酸，氰基乙酸，柠康酸，甲基膦酸，肌氨酸，糖精或其组合。 以足够的量加入缓冲液，以将测定液的pH值保持在约2.0至约3.0范围内的选定目标pH范围。 染料具有使其能够在目标pH范围内作为蛋白质指示剂操作的pKa。 染料还对蛋白质具有亲和力，使得其在大于约15mg / dL蛋白质的存在下提供可检测的响应，从而使测定法适合于检测测试流体中的总蛋白质。 缓冲液和染料可以吸收在吸收材料的测试条中。

    Spiro[indoline-3,4'-piperidine]s and related compounds
    27.
    发明授权
    Spiro[indoline-3,4'-piperidine]s and related compounds 失效
    螺[二氢吲哚-3,4'-哌啶]和相关化合物

    公开(公告)号：US4477667A

    公开(公告)日：1984-10-16

    申请号：US332251

    申请日：1981-12-18

    Applicant: Helen H. Ong ,  James A. Profitt

    Inventor： Helen H. Ong ,  James A. Profitt

    IPC: C07D211/64 ,  C07D471/10

    CPC classification number: C07D471/10 ,  C07D211/64

    Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.

    Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。

    Polarized Optics for Optical Diagnostic Device
    28.
    发明申请
    Polarized Optics for Optical Diagnostic Device 审中-公开
    光学诊断设备的极化光学

    公开(公告)号：US20110223673A1

    公开(公告)日：2011-09-15

    申请号：US13129937

    申请日：2009-11-16

    Applicant: James A. Profitt

    Inventor： James A. Profitt

    IPC: G01N21/00

    CPC classification number: G01N21/78 ,  G01N21/21 ,  G01N21/8483 ,  G01N2021/8488 ,  Y10T436/10

    Abstract: A readhead for a photometric diagnostic instrument includes a holder configured for receiving reagent sample media therein. The sample media has a plurality of test areas configured to react with, and change color, according to an amount of an analyte in a sample. The holder is sized and shaped for forming an indexed fit with the sample media. One or more light sources are configured to emit light onto the test areas. First and second polarized light filters are respectively disposed between the light sources and the test areas, and between the test areas and one or more light detectors, so that the light detectors receive diffuse, non-specular reflections of the light from the test areas, while substantially preventing the light detectors from receiving specular reflections of the light.

    Abstract translation: 用于光度测量诊断仪的读取头包括配置用于在其中接收试剂样品介质的保持器。 样品介质具有多个测试区域，其被配置为根据样品中分析物的量反应并改变颜色。 支架的尺寸和形状用于与样品介质形成索引配合。 一个或多个光源被配置为将光发射到测试区域。 第一和第二偏振光滤光器分别设置在光源和测试区域之间以及测试区域和一个或多个光检测器之间，使得光检测器接收来自测试区域的光的漫反射，非镜面反射， 同时基本上防止光检测器接收光的镜面反射。

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