公开(公告)号：US07915916B2

公开(公告)日：2011-03-29

申请号：US11421614

申请日：2006-06-01

Applicant: William J. Wilcox ,  James C. Davis ,  Dwayne K. Kreipl ,  Michael B. Pearson

Inventor： William J. Wilcox ,  James C. Davis ,  Dwayne K. Kreipl ,  Michael B. Pearson

IPC: G06F7/38 ,  H03K19/173 ,  H03K19/094 ,  G11C17/00 ,  G11C17/18

CPC classification number: H03K19/17748 ,  H03K19/1776 ,  H03K19/1778

Abstract: An antifuse circuit includes a terminal, an antifuse, and a select transistor. The antifuse is coupled to the terminal and has an associated program voltage. The select transistor is coupled to the antifuse and has a gate terminal coupled to receive a first select signal. The select transistor operates in a snapback mode of operation in response to an assertion of the first select signal and the program voltage at the terminal.

Abstract translation: 反熔丝电路包括端子，反熔丝和选择晶体管。 反熔丝耦合到终端并具有相关的编程电压。 选择晶体管耦合到反熔丝，并且具有耦合以接收第一选择信号的栅极端子。 响应于终端处的第一选择信号和程序电压的断言，选择晶体管工作在快速恢复操作模式。

公开(公告)号：US20090043087A1

公开(公告)日：2009-02-12

申请号：US12075700

申请日：2008-03-12

Applicant: James C. Davis ,  Martin A. Smith ,  Frank D. Igoe ,  Marcela A. Vera-Garcia

Inventor： James C. Davis ,  Martin A. Smith ,  Frank D. Igoe ,  Marcela A. Vera-Garcia

IPC: C07H21/00 ,  C12M1/12

CPC classification number: C12N15/1017

Abstract: This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided.

Abstract translation: 本发明涉及从高度颗粒物质如细胞碎片和固体（包括悬浮固体）严重污染​​的来源快速核酸纯化的方法。 特别地，本发明提供了用于快速，可量化回收和纯化来自严重被固体污染的各种来源的核酸的方法，例如小生物，组织样品，在土壤上发现的血液样品或从食物中洗涤的样品， 由于其阻塞过滤器和色谱柱的倾向，核酸分离常常是困难的来源。 还提供了一个设备和套件。

公开(公告)号：US06881543B2

公开(公告)日：2005-04-19

申请号：US09993736

申请日：2001-11-14

Applicant: Richard Philpott ,  Martin A. Smith ,  Frank D. Igoe ,  James C. Davis

Inventor： Richard Philpott ,  Martin A. Smith ,  Frank D. Igoe ,  James C. Davis

IPC: C12N15/10 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12N15/1017 ,  C12Q1/6806 ,  Y10S977/924

Abstract: The invention relates to methods, a kit, and an apparatus for detecting and analyzing genetic material from a biological sample. The method can be used to analyze samples from a wide variety of sources, including tissues, blood, plasma, sera, mucus, urine, saliva, sweat, semen, and cultures, as well as analyzing samples of contaminated water, food, beverages, and other items.

Abstract translation: 本发明涉及用于从生物样品中检测和分析遗传物质的方法，试剂盒和装置。 该方法可用于分析各种来源的样品，包括组织，血液，血浆，血清，粘液，尿液，唾液，汗液，精液和培养物，以及分析污染水，食品，饮料， 和其他项目。

公开(公告)号：US06645717B1

公开(公告)日：2003-11-11

申请号：US09507548

申请日：2000-02-18

Applicant: Martin A. Smith ,  Mridula Iyer ,  Daqing Qu ,  James C. Davis

Inventor： Martin A. Smith ,  Mridula Iyer ,  Daqing Qu ,  James C. Davis

IPC: C12Q168

CPC classification number: C12N1/06 ,  B01L3/5023 ,  B01L3/5029 ,  B01L2300/0822 ,  B01L2300/163 ,  C12N15/1006 ,  C12Q1/6806 ,  G01N1/405 ,  Y10T436/143333 ,  C12Q2565/625

Abstract: A medium for storage and subsequent analysis of a genetic material includes a support for immobilizing the genetic material thereon and allowing subsequent elution of the genetic material therefrom and a coating functionally associated with the support for enabling cellular lysis and releasing the genetic material from the lysed cells while stabilizing the immobilized released genetic material. A method of storing the genetic material and subsequently analyzing the genetic material includes the steps of immobilizing the genetic material on a support while enabling cellular lysis and release of genetic material from the lysed cells and stabilizing the immobilized released genetic material on the support. The genetic material is then eluted to generate a soluble genetic material fraction. The eluted genetic material can be analyzed.

Abstract translation: 用于遗传物质的储存和随后分析的培养基包括用于将遗传物质固定在其上的载体，并允许随后从其中洗脱遗传物质和与支持物功能相关的涂层，以使细胞裂解并从裂解的细胞释放遗传物质 同时稳定固定化的释放的遗传物质。存储遗传物质并随后分析遗传物质的方法包括将遗传物质固定在载体上的步骤，同时能够从裂解的细胞中细胞裂解和释放遗传物质并稳定固定的释放 遗传物质的支持。 然后洗脱遗传物质以产生可溶性遗传物质级分。 可以分析洗脱的遗传物质。

公开(公告)号：US6158941A

公开(公告)日：2000-12-12

申请号：US228305

申请日：1999-01-12

Applicant: Richard S. Muka ,  James C. Davis, Jr. ,  Christopher A. Hofmeister

Inventor： Richard S. Muka ,  James C. Davis, Jr. ,  Christopher A. Hofmeister

IPC: B25J9/06 ,  B25J9/10 ,  B25J18/02 ,  H01L21/677 ,  H01L21/687 ,  B65H5/00

CPC classification number: H01L21/67781 ,  B25J9/107 ,  H01L21/68707 ,  Y10S414/135 ,  Y10S414/137 ,  Y10T74/20305

Abstract: A substrate processing apparatus having a supply of substrates, a substrate transport module, and a substrate processing module. The transport module has a movable arm assembly and two substrate holders mounted to the movable arm assembly. The substrate holders each have two separate holding areas for simultaneously holding two substrates. The movable arm assembly has two pairs of driven arms. Each pair of driven arms is connected to a separate one of the holders for extending and retracting the holders along a radial path relative to a center of the movable arm assembly.

Abstract translation: 具有基板供给的基板处理装置，基板输送模块和基板处理模块。 运输模块具有可移动臂组件和安装到可动臂组件上的两个衬底保持架。 衬底保持器各具有两个独立的保持区域，用于同时保持两个衬底。 可动臂组件具有两对从动臂。 每对从动臂连接到单独的一个保持器，用于相对于可动臂组件的中心沿径向路径延伸和缩回保持器。

公开(公告)号：US5539323A

公开(公告)日：1996-07-23

申请号：US58421

申请日：1993-05-07

Applicant: James C. Davis, Jr.

Inventor： James C. Davis, Jr.

IPC: G01V3/08 ,  G01D5/24 ,  G01R27/26 ,  G01V9/00 ,  H01L21/67 ,  G01N27/00

CPC classification number: G01D5/2405 ,  G01V9/00

Abstract: The presence of an article at a specified location is detected by measuring a change in capacitance which is caused by the placement of the article at the specified location. The device used for this measurement includes an oscillator the frequency whereof is rendered highly sensitive to the capacitance being measured by structure which includes a triaxial cable and by electrical circuitry which includes a voltage follower circuit.

Abstract translation: 通过测量由于在指定位置处的物品的放置而引起的电容变化来检测在指定位置处的物品的存在。 用于该测量的装置包括振荡器，其频率对由包括三轴电缆以及包括电压跟随器电路的电路测量的电容高度敏感。

公开(公告)号：US5164081A

公开(公告)日：1992-11-17

申请号：US588007

申请日：1990-09-25

Applicant: Randall W. Nichols ,  James C. Davis ,  Robert D. Littler

Inventor： Randall W. Nichols ,  James C. Davis ,  Robert D. Littler

IPC: B01D63/02 ,  B01D63/04 ,  B29C41/20 ,  B29C41/22 ,  B29C70/84

CPC classification number: B01D63/026 ,  B01D63/02 ,  B01D63/022 ,  B01D63/043 ,  B29C41/20 ,  B29C41/22 ,  B29C70/845

Abstract: A multi port apparatus (220,440) provides for the treatment of material. Such apparatus comprises at least one wafer (240,320,410), each wafer comprising a central area (246,325,416) providing a plurality of members (18,303,309,360) arranged in a plurality of layers (262,306,308,432) first peripheral support means (241,321,411) encompassing the central area and having upper and lower surfaces (244,245,324,414,415); second peripheral support means (248,326,418), having upper and lower surfaces (251,252,330,421,422) and carried radially outwardly from the first peripheral support means; and a plurality of separate bore fluid chambers (253-256, 335-338, 423-426) defined between the first and second peripheral support means and communicable with the central area; vessel means (228,448) providing a first port (221,441) a second port (222,442) and a plurality of separate bore fluid port means (223-226, 443-446) communicating with the four separate bore fluid chambers; and means for compressing (234,454) at least one wafer within the apparatus. The present invention also provides three and four port apparatus (60,180). Multi-chambered wafers (240,320,410) are provided as well as wafers (200,280,300,350 and 460) for use in the multi port apparatus. Finally, methods for the manufacture of wafers are provided.

Abstract translation: 多端口设备（220,440）提供材料的处理。 这种设备包括至少一个晶片（240,320,410），每个晶片包括中心区域（246,325,416），中心区域（246,325,416）提供布置在多个层（262,306,308,432）中的多个构件（18,303,309,360），第一周边支撑装置（241,321,411）包围中心区域并具有 上表面和下表面（244,245,324,414,415）; 第二周边支撑装置（248,326,418），具有上表面和下表面（251,252,330,421,422）并且从第一周边支撑装置径向向外承载; 和限定在第一和第二外围支撑装置之间且可与中央区域通信的多个单独的孔流体室（253-256,335-338,423-426） 提供第一端口（221,441）和第二端口（222,442）的容器装置（228,448）以及与四个单独的孔流体室连通的多个单独的孔流体端口装置（223-226,443-446） 以及用于在所述装置内压缩（234,454）至少一个晶片的装置。 本发明还提供三端口和四端口设备（60,180）。 提供多腔晶片（240,320,410）以及用于多端口设备的晶片（200,280,300,350和460）。 最后，提供了制造晶片的方法。

公开(公告)号：US4963264A

公开(公告)日：1990-10-16

申请号：US742872

申请日：1985-06-10

Applicant: James C. Davis

Inventor： James C. Davis

IPC: C22B3/24 ,  B01D15/00 ,  B01D15/02 ,  B01D15/08 ,  B01D61/24 ,  B01D61/26 ,  B01D61/30 ,  B01D61/32 ,  B01D61/58 ,  B01D65/10 ,  C07K1/32 ,  C08J5/22 ,  C10G31/11 ,  C10G33/06 ,  C13K1/04 ,  C13K11/00 ,  C22B3/00 ,  C22B15/00 ,  C22B26/10 ,  C22B26/20 ,  C22B59/00 ,  G01N30/02 ,  G01N30/84

CPC classification number: B01D15/00 ,  B01D15/361 ,  B01D61/243 ,  C07K1/32 ,  C10G31/11 ,  C10G33/06 ,  C13K1/04 ,  C13K11/00 ,  C22B3/24 ,  B01D15/3809 ,  B01D2311/04 ,  B01D2311/08 ,  Y02P10/234

Abstract: A process for the selective dialysis of liquid streams containing different materials comprises the steps of providing a porous membrane in a cell, the membrane having pores of sufficient dimension to allow passage of the different materials therethrough, circulating an affinity adsorbent stream against a first side of the membrane, where the adsorbent has a dimension larger than that of the pores and has a binding capacity for at least one but not all of the different materials and, passing the liquid stream containing the different materials against a second side of the membrane whereby certain of the materials become bound to the adsorbent upon passing through the membrane to the first side thereof and become separated from others of the materials which can return to the second side of the membrane. A separate stripping process is also provided which can be employed in conjunction with the dialysis process or alone where it is desirable to remove bound materials from an affinity adsorbent material.

Abstract translation: 用于选择性透析含有不同材料的液体流的方法包括在细胞中提供多孔膜的步骤，所述膜具有足够尺寸的孔，以允许不同材料通过，使亲和吸附剂流循环到第一侧 膜，其中吸附剂的尺寸大于孔的尺寸，并且具有至少一种但不是全部不同材料的结合能力，并且使含有不同材料的液体流抵靠膜的第二侧，由此某些 的材料在通过膜到其第一侧时与吸附剂结合，并且与能够返回到膜的第二侧的材料中的其它物质分离。 还提供单独的汽提过程，其可以与透析过程联合使用，或单独使用，其中期望从亲和吸附剂材料除去结合的材料。

公开(公告)号：US4770784A

公开(公告)日：1988-09-13

申请号：US802836

申请日：1985-11-29

Applicant: James C. Davis ,  Michael F. McGuiggan ,  Terry Berrett

Inventor： James C. Davis ,  Michael F. McGuiggan ,  Terry Berrett

IPC: B01D61/16 ,  B01D15/02 ,  B01D61/22 ,  B01D61/24 ,  B01D61/32 ,  B01D61/34 ,  B01D61/58 ,  B01D69/00 ,  B01D13/00

CPC classification number: B01D15/02 ,  B01D61/246 ,  B01D61/32 ,  B01D2215/021 ,  B01D2311/04 ,  B01D2311/08 ,  Y10S210/905 ,  Y10S210/908 ,  Y10S210/912

Abstract: A scrubbing process for high feed concentrations of different materials in liquid streams. The process calls for providing a porous membrane in a cell, the membrane having pores of sufficient dimension to allow passage of the different materials therethrough; providing a first stream comprising the different materials in a liquid carrier, providing a second stream comprising an affinity adsorbent in a second liquid carrier, wherein the affinity adsorbent has a dimension larger than that of the pores and has a preferred binding capacity for at least one but not all of the different materials; mixing the first and second streams together to form a composite mixture wherein a portion of the different materials become bound to the affinity adsorbent and a portion of the different materials remain essentially unbound to the affinity adsorbent; and passing the composite mixture against a first side of the membrane while passing a liquid carrier for any of the unbound material against a second side of the membrane to produce a first exit stream containing the affinity adsorbent and a high concentration of at least one of the different materials and a second exit stream containing the liquid carrier and a high concentration of at least one of the other different materials.

Abstract translation: 用于液体流中不同材料的高进料浓度的洗涤方法。 该方法要求在细胞中提供多孔膜，所述膜具有足够尺寸的孔以允许不同材料通过其中; 提供在液体载体中包含不同材料的第一流，在第二液体载体中提供包含亲和吸附剂的第二流，其中所述亲和吸附剂的尺寸大于孔的尺寸，并且对于至少一个 但不是全部不同的材料; 将第一和第二流混合在一起以形成复合混合物，其中不同材料的一部分与亲和吸附剂结合，并且不同材料的一部分基本上不结合到亲和吸附剂; 以及使所述复合混合物抵靠所述膜的第一侧，同时使任何未结合材料的液体载体抵靠所述膜的第二侧，以产生含有所述亲和吸附剂的第一出口流和高浓度的至少一种 不同的材料和含有液体载体的第二出口流和高浓度的至少一种其它不同的材料。

公开(公告)号：US4474664A

公开(公告)日：1984-10-02

申请号：US429357

申请日：1982-09-30

Applicant: Timothy S. Stevens ,  James C. Davis ,  Hamish Small

Inventor： Timothy S. Stevens ,  James C. Davis ,  Hamish Small

IPC: G01N30/60 ,  G01N30/84 ,  G01N30/96 ,  G01N31/04

CPC classification number: G01N30/84 ,  G01N30/96 ,  G01N2030/8435 ,  G01N2030/965

Abstract: A permselective ion-exchange membrane, preferably comprising hollow fiber(s) immersed within a regenerant, is used to selectively neutralize or suppress the conductivity of electrolyte in a stream of eluent also containing chromatographically separated ions. The invention particularly specifies a chromatographic separating column useful with an electrolyte eluent solution to separate ionic species by elution chromatography, wherein the effluent of the separator column is treated by the described membrane to suppress the conductivity of the electrolyte but not that of the separated ions.

Abstract translation: 优选包含浸入再生剂中的中空纤维的选择性选择性离子交换膜用于选择性中和或抑制还含有色谱分离的离子的洗脱液流中的电解质的导电性。 本发明特别规定了一种色谱分离柱，其用于电解液洗脱溶液以通过洗脱色谱分离离子物质，其中通过所述膜处理分离塔的流出物以抑制电解质的导电性，而不是分离离子的导电性。